Showing entry for Tissue alpha-L-fucosidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006142
Protein NameTissue alpha-L-fucosidase
Uniport IdP04066
GeneFUCA1
Gene Id2517
DomainAlpha_L_fucos; Fucosidase_C
Pfam PF01120   PF16757  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00511 Other glycan degradation
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006004 fucose metabolic process
Biological Process GO:0019377 glycolipid catabolic process
Biological Process GO:0006027 glycosaminoglycan catabolic process
Biological Process GO:0016139 glycoside catabolic process
Biological Process GO:0043312 neutrophil degranulation
molecular function GO:0004560 alpha-L-fucosidase activity
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005764 lysosome
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002985 BXGD000164 Angiokeratoma Neoplasms
C0003028 BXGD000170 Anhidrosis Skin and Connective Tissue Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016788 BXGD001081 Fucosidase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027533 BXGD001995 Neck Neoplasms Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0086795 BXGD003311 Pfaundler-Hurler Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0162819 BXGD003984 Skin Diseases, Vascular Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206694 BXGD004245 Mucoepidermoid Carcinoma Neoplasms
C0221347 BXGD004442 Acrocyanosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Respiratory Tract Diseases; Cardiovascular Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239137 BXGD004965 Coxa valga Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0264172 BXGD005371 Barrel chest Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266249 BXGD005635 Gallbladder anomaly congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0268221 BXGD005855 Fucosidosis Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268222 BXGD005856 Fucosidosis Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0349588 BXGD007933 Short stature
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0426421 BXGD008561 Wide nose
C0426886 BXGD008594 Tapering fingers (finding)
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0853087 BXGD010964 Nail abnormality Pathological Conditions, Signs and Symptoms
C0861352 BXGD011246 Lobular Neoplasia Neoplasms; Skin and Connective Tissue Diseases
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1834124 BXGD013956 Shield chest
C1836542 BXGD014129 Depressed nasal bridge
C1836855 BXGD014170 Vacuolated lymphocytes
C1837108 BXGD014199 Decreased muscle mass
C1837260 BXGD014214 Prominent forehead
C1839739 BXGD014400 Thick lower lip vermilion
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853487 BXGD015340 Thick eyebrow
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1855391 BXGD015494 Tortuosity of conjunctival vessels
C1856639 BXGD015623 Absent/hypoplastic paranasal sinuses
C1856641 BXGD015624 Cervical platyspondyly
C1856644 BXGD015625 Absent/hypoplastic coccyx
C1856646 BXGD015626 Elevated sweat chloride
C1963094 BXGD016681 Dry Skin, CTCAE
C1969913 BXGD016800 Generalized hyperkeratosis
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2919142 BXGD017867 Short Stature, CTCAE
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C4021541 BXGD020662 Anterior beaking of lumbar vertebrae
C4021664 BXGD020727 Abnormality of the abdominal wall Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4023815 BXGD021270 Oligosacchariduria
C4024726 BXGD021387 Mucopolysacchariduria
C4025302 BXGD021634 Anterior beaking of thoracic vertebrae
C4317149 BXGD022731 Vacuolated Lymphocyte Count
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000536 Phenol 94.11
BXGC0007162 N-Methyl-1-deoxynojirimycin 177.2
BXGC0014532 hyacinthacine C4 219.11
BXGC0017977 Hyacinthacine C3 219.11
BXGC0021071 Hyacinthacine C5 219.11
BXGC0024003 Hyacinthacine C2 219.11
BXGC0026858 Deoxyfuconojirimycin 147.09
BXGC0029591 n.a 193.1
BXGC0030236 Deoxymannojirimycin 163.08
BXGC0032319 L-Ido-1-Deoxynojirimycin 163.08
BXGC0035493 hyacinthacine B7 203.12
BXGC0035886 beta-1-C-ethyl-1-deoxymannojirimycin 191.12
BXGC0037065 L-Fucose 164.07
BXGC0038823 3-Epifagomine 147.09
BXGC0040755 Beta-Homofuconojirimycin 177.1
BXGC0041132 Duvoglustat 163.08
BXGC0045295 n.a 193.1
BXGC0045322 n.a 193.1
BXGC0045813 Alpha-5-C-(3-Hydroxybutyl)Hyacinthacine A1 245.16
BXGC0049562 L-1-Deoxynojirimycin 163.08
BXGC0050422 n.a 193.1
BXGC0050608 Fagomine 147.09
BXGC0051203 2,5-Dideoxy-2,5-Imino-D-Mannitol 163.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein