Showing entry for (2R,3R,4R)-2-(Hydroxymethyl)Pyrrolidine-3,4-Diol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0041896
Compound Name(2R,3R,4R)-2-(Hydroxymethyl)Pyrrolidine-3,4-Diol
Structure
FormulaC5H11NO3
InchiKeyOQEBIHBLFRADNM-UOWFLXDJSA-N
SMILESOC[C@H]1NC[C@H]([C@@H]1O)O
InchiInChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m1/s1
IUPAC(2R,3R,4R)-2-(hydroxymethyl)pyrrolidine-3,4-diol
Molecular Weight133.07
Pubchem Id451991
Chembl IdCHEMBL80254
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB 1AB
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00489 BXGT005553 Glycogen phosphorylase, muscle form reviewed PYGM - 342 - - -
H9J974 BXGT024767 Aamy domain-containing protein unreviewed - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL80254
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 35481 nM
P21139 BXGT008624 Alpha-mannosidase 2C1 reviewed - Man2c1 IC50 '<' 50000 nM
P00489 BXGT005553 Glycogen phosphorylase, muscle form reviewed - PYGM Ki '=' 400 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 55000 nM
Q42656 BXGT014579 Alpha-galactosidase reviewed - Inhibition '<' 50 %
Q2KIM0 BXGT014117 Tissue alpha-L-fucosidase reviewed - FUCA1 Inhibition '<' 50 %
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 5800 nM
Q6P762 BXGT016459 Alpha-mannosidase unreviewed - Man2b1 IC50 '=' 110000 nM
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase reviewed - GBA2 IC50 '=' 120000 nM
C0HJB3 BXGT002376 Alpha-mannosidase reviewed - Inhibition - - -
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 16000 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 562 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 562 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 562 nM
P21139 BXGT008624 Alpha-mannosidase 2C1 reviewed - Man2c1 IC50 '=' 100000 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM IC50 '=' 55000 nM
O70282 BXGT005062 Trehalase unreviewed - IC50 '=' 25000 nM
P07265 BXGT006583 Alpha-glucosidase MAL62 reviewed - MAL62 IC50 '=' 840 nM
P28494 BXGT009264 Alpha-mannosidase 2 reviewed - Man2a1 IC50 '=' 46000 nM
Q42656 BXGT014579 Alpha-galactosidase reviewed - Inhibition - - -
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 Inhibition '<' 50 %
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 55000 nM
P09811 BXGT006925 Glycogen phosphorylase, liver form reviewed - Pygl IC50 '=' 1100 nM
P28494 BXGT009264 Alpha-mannosidase 2 reviewed - Man2a1 Ki '=' 35000 nM
Q4FZV0 BXGT014807 Beta-mannosidase reviewed - Manba IC50 '=' 290000 nM
P06737 BXGT006492 Glycogen phosphorylase, liver form reviewed Enzyme PYGL Ki '=' 400 nM
I3LIR5 BXGT003674 Trehalase unreviewed - TREH IC50 '=' 2500 nM
P35573 BXGT009850 Glycogen debranching enzyme reviewed Enzyme AGL IC50 '=' 8400 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1258 nM
P00722 BXGT005626 Beta-galactosidase reviewed - lacZ Inhibition - - -
P08019 BXGT006715 Glucoamylase, intracellular sporulation-specific reviewed - SGA1 IC50 '=' 150 nM
P09811 BXGT006925 Glycogen phosphorylase, liver form reviewed - Pygl IC50 '=' 1000 nM
Q02401 BXGT012651 Lactase-phlorizin hydrolase reviewed - Lct IC50 '=' 260000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01194 Stellaria dichotoma Stellaria dichotoma Others
BXGF02214 Morus bombycis Morus bombycis Medicinal Plant
BXGF03999 Angylocalyx pynaertii Angylocalyx pynaertii Others
BXGF04607 Morus alba Morus alba Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease