Showing entry for Importin subunit beta-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013516
Protein NameImportin subunit beta-1
Uniport IdQ14974
GeneKPNB1
Gene Id3837
DomainIBN_N
Pfam PF03810  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006309 apoptotic DNA fragmentation
Biological Process GO:0030953 astral microtubule organization
Biological Process GO:0040001 establishment of mitotic spindle localization
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0075733 intracellular transport of virus
Biological Process GO:0007079 mitotic chromosome movement towards spindle pole
Biological Process GO:0007080 mitotic metaphase plate congression
Biological Process GO:0090307 mitotic spindle assembly
Biological Process GO:0019054 modulation by virus of host cellular process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0006607 NLS-bearing protein import into nucleus
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0031291 Ran protein signal transduction
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0006610 ribosomal protein import into nucleus
molecular function GO:0019899 enzyme binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0061676 importin-alpha family protein binding
molecular function GO:0061608 nuclear import signal receptor activity
molecular function GO:0008139 nuclear localization sequence binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0008536 Ran GTPase binding
molecular function GO:0003723 RNA binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0005829 cytosol
cellular component GO:0071782 endoplasmic reticulum tubular network
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0043657 host cell
cellular component GO:0016020 membrane
cellular component GO:0005635 nuclear envelope
cellular component GO:0031965 nuclear membrane
cellular component GO:0005643 nuclear pore
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0035580 specific granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-140342 Apoptosis induced DNA fragmentation
R-HSA-1430728 Metabolism
R-HSA-162906 HIV Infection
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-168249 Innate Immune System
R-HSA-168255 Influenza Infection
R-HSA-168256 Immune System
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-5357801 Programmed Cell Death
R-HSA-556833 Metabolism of lipids
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-6798695 Neutrophil degranulation
R-HSA-68882 Mitotic Anaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-75153 Apoptotic execution phase
R-HSA-8957322 Metabolism of steroids
R-HSA-913531 Interferon Signaling
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation
R-HSA-9635486 Infection with Mycobacterium tuberculosis
R-HSA-9636249 Inhibition of nitric oxide production
R-HSA-9637687 Suppression of phagosomal maturation
R-HSA-9637690 Response of Mtb to phagocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011311 BXGD000714 Dengue Fever Infections
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0025007 BXGD001821 Measles Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0278622 BXGD006551 Adult Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279987 BXGD006706 Childhood Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0458960 BXGD008909 Peripheral neuropathic pain
C0523677 BXGD009215 Glycine measurement
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C3714514 BXGD019409 Infection Infections
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000286 L-DOPA 197.19
BXGC0000324 Isovitexin 432.38
BXGC0000556 1H-Imidazole-1-acetic acid 126.11
BXGC0000563 1H-Indole-3-methanol 147.17
BXGC0000651 Harmalan 184.24
BXGC0000663 Papain 206.28
BXGC0000681 Umbelliferone 162.14
BXGC0000805 Bis(2-furanylmethyl) disulfide 226.32
BXGC0000999 Peucedanin 258.27
BXGC0001167 Isoorientin 7-O-(6'''-O-(E)-feruloyl)glucoside 448.38
BXGC0001174 Xanthoangelol H 354.4
BXGC0001325 Progesterone 314.46
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0001495 (R)-Roemerine 279.33
BXGC0001544 Harmaline 214.26
BXGC0001747 Rosmarinic acid 360.31
BXGC0001782 Sennoside B 862.74
BXGC0001825 (R)-Oxypeucedanin 286.28
BXGC0001857 Caffeic acid 180.16
BXGC0001876 Chrysoeriol 300.26
BXGC0002052 Aesculetin 178.14
BXGC0002061 Aloeemodin 270.24
BXGC0002064 Amentoflavone 538.46
BXGC0002690 alpha-Catechin 290.27
BXGC0002801 Phellopterin 300.31
BXGC0002906 Caffeic acid ester 284.31
BXGC0003852 Nigrin B 506.47
BXGC0003982 5-Hydroxyuracil 128.09
BXGC0003992 Imidazoleacrylic acid 138.12
BXGC0004322 xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside 356.37
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0004497 3-O-Acetylepisamarcandin 442.54
BXGC0004753 Phthalic acid 166.13
BXGC0005017 4,7-Dihydroxy-2H-1-benzopyran-2-one 178.14
BXGC0005049 4-Methylumbelliferyl acetate 218.21
BXGC0005319 Garcinone E 464.55
BXGC0005497 Syringin 372.37
BXGC0005615 L-Galactose 180.16
BXGC0005667 Quercitrin 448.38
BXGC0005721 Bisdemethoxycurcumin 308.33
BXGC0005806 Glycyrol 366.36
BXGC0005915 Formononetin 268.27
BXGC0005982 Curcumin 368.38
BXGC0006062 Isoorientin 448.38
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0006193 Ellagic acid 302.19
BXGC0006291 Scopoletin 192.17
BXGC0006367 Mangiferin 422.34
BXGC0006635 Luteolin 286.24
BXGC0007533 Biotin 244.31
BXGC0007821 Linalool 154.25
BXGC0008824 Astragalin 448.38
BXGC0008912 Panasenoside 610.52
BXGC0009194 Quercetin 3-glucuronide 478.36
BXGC0010010 3,8''-Biapigenin 538.46
BXGC0011421 3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone 166.17
BXGC0012321 Menatetrenone 444.66
BXGC0012651 Schizandrin 432.21
BXGC0012874 Continentalic acid 302.22
BXGC0013068 3-(4-Hydroxyphenyl)-6-Methoxy-7-[3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-4-One 446.12
BXGC0013582 Curcumin 368.13
BXGC0014736 Isovanillin 152.05
BXGC0014870 4,5-Dimethoxy-11-Methyl-[1,3]Dioxolo[4,5-C]Acridin-6-One 313.1
BXGC0015879 Chlorhexidine 504.2
BXGC0017158 thunberginol A 270.05
BXGC0017757 Androstenedione 286.19
BXGC0017933 Sulfuretin 270.05
BXGC0018252 Embelin 294.18
BXGC0020311 Melicopidine 313.1
BXGC0020578 7alpha-Hydroxy-EPIA 306.22
BXGC0020756 4-(1,3-Benzothiazol-2-Yl)-2-Methylaniline 240.07
BXGC0020995 6-[(3E,5E,7S)-5,7-Dimethyl-2-Oxonona-3,5-Dienyl]-2,4-Dihydroxy-3-Methylbenzaldehyde 316.17
BXGC0021255 4-[(3S)-8,8-Dimethyl-3,4-Dihydro-2H-Pyrano[2,3-F]Chromen-3-Yl]Benzene-1,3-Diol 324.14
BXGC0021553 Perillic Acid 166.1
BXGC0021666 dicentrine 339.15
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
BXGC0022806 1-(5-Thiophen-2-Ylthiophen-2-Yl)Ethanone 208
BXGC0022865 (2S)-2-Hydroxy-2-Phenylacetic Acid 152.05
BXGC0023488 ginkgolide A 408.14
BXGC0023872 Adenine 135.05
BXGC0024141 Hydrocortisone 362.21
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024489 Licarin A 326.15
BXGC0024813 Demethoxycurcumin 338.12
BXGC0025386 Gitoxin 780.43
BXGC0025876 Acetoside 624.21
BXGC0026607 epiberberine 336.12
BXGC0026973 3-(3,4-Dimethoxyphenyl)propionic acid 210.09
BXGC0027312 Norarmepavine 299.15
BXGC0028036 Esculin hydrate 340.08
BXGC0028067 Enniatin B 639.41
BXGC0028104 Hyoscyamine 289.17
BXGC0028113 Fraxine 370.09
BXGC0029291 Diphyllin 380.09
BXGC0029320 geniposide 388.14
BXGC0029721 Sclerotiorin 390.12
BXGC0029807 Anisocoumarin H 314.15
BXGC0030010 Michler's Ketone 268.16
BXGC0030085 Bicuculline 367.11
BXGC0030248 2-(4-Hydroxyphenyl)Chromen-4-One 238.06
BXGC0030714 Daphnoretin 352.06
BXGC0031067 6,7-Dimethoxy-3H-2-Benzofuran-1-One 194.06
BXGC0031233 Umbelliprenin 366.22
BXGC0031642 alpha-Tocopherol 472.39
BXGC0031733 (24S)-6alpha-(2-O-alpha-L-Rhamnopyranosyl-6-O-acetyl-beta-D-glucopyranosyloxy)-20,24-epoxydammarane-3beta,12beta,25-triol 842.5
BXGC0031881 4-methoxy-5-hydroxycanthin-6-one 266.07
BXGC0031951 Aristolochic D 357.05
BXGC0032061 Methylmalonic Acid 118.03
BXGC0033960 3-Hydroxybenzo[C]Chromen-6-One 212.05
BXGC0034968 Dienestrol 266.13
BXGC0035557 Pratol 268.07
BXGC0035776 BRUCEOLIDE 438.15
BXGC0036458 4-(2-Methylbutan-2-Yl)Phenol 164.12
BXGC0036864 Cyclovalone 366.15
BXGC0038066 Rescinnamine 634.29
BXGC0038197 2-Methoxyphenazine 210.08
BXGC0038233 Nalidixic Acid 232.08
BXGC0038660 Tenulin 306.15
BXGC0039153 N-Acetylneuraminic Acid 309.11
BXGC0039172 Oxyresveratrol 244.07
BXGC0039397 Athraquinones A 240.04
BXGC0040305 Indirubin 262.07
BXGC0040936 Sid26657808 284.07
BXGC0041896 (2R,3R,4R)-2-(Hydroxymethyl)Pyrrolidine-3,4-Diol 133.07
BXGC0042035 raubasine 352.18
BXGC0042107 Methyl 18-Hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 354.19
BXGC0042256 1,4-Bis[[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxy]-3,5-Dihydroxycyclohexane-1-Carboxylic Acid 516.13
BXGC0042336 7-Amino-4-Hydroxynaphthalene-2-Sulfonic Acid 239.03
BXGC0042397 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-Methyl-2,3-Dihydrochromen-4-One 286.08
BXGC0042678 Ambrosin 246.13
BXGC0043703 Domoic Acid 311.14
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0046559 Paraxanthine 180.06
BXGC0046755 Yohimbine 354.19
BXGC0046862 Benzo[Def]Chrysene 252.09
BXGC0047169 Hymecromone 176.05
BXGC0047871 7-Hydroxyflavone 238.06
BXGC0049516 Kainic Acid 213.1
BXGC0050284 10-Hydroxycamptothecin 364.11
BXGC0050599 tetrandrine 622.3
BXGC0050877 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-Dihydro-2H-Chromene-3,5,7-Triol;Hydrate 290.08
BXGC0051082 4-Hydroxy-2-methoxybenzaldehyde 152.05
BXGC0052370 ginkgolide C 440.13
BXGC0052374 Reserpine 608.27
BXGC0052878 Bisphenol A 228.12
BXGC0053235 Fraxetin 208.04
BXGC0053259 Liriodendrtachioside 742.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein