Showing entry for GTP-binding nuclear protein Ran


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011463
Protein NameGTP-binding nuclear protein Ran
Uniport IdP62826
GeneRAN
Gene Id5901
DomainRas
Pfam PF00071  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03008 Ribosome biogenesis in eukaryotes
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051301 cell division
Biological Process GO:0034629 cellular protein-containing complex localization
Biological Process GO:0006259 DNA metabolic process
Biological Process GO:0046039 GTP metabolic process
Biological Process GO:0075733 intracellular transport of virus
Biological Process GO:0010586 miRNA metabolic process
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0000070 mitotic sister chromatid segregation
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0035281 pre-miRNA export from nucleus
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:1902570 protein localization to nucleolus
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0000055 ribosomal large subunit export from nucleus
Biological Process GO:0000056 ribosomal small subunit export from nucleus
Biological Process GO:0000054 ribosomal subunit export from nucleus
Biological Process GO:0061015 snRNA import into nucleus
Biological Process GO:0006409 tRNA export from nucleus
Biological Process GO:0016032 viral process
molecular function GO:0045296 cadherin binding
molecular function GO:0003682 chromatin binding
molecular function GO:0019003 GDP binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0003723 RNA binding
cellular component GO:0005814 centriole
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0043657 host cell
cellular component GO:0042470 melanosome
cellular component GO:0016020 membrane
cellular component GO:0030496 midbody
cellular component GO:0005635 nuclear envelope
cellular component GO:0005643 nuclear pore
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0055037 recycling endosome
cellular component GO:0042565 RNA nuclear export complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-168255 Influenza Infection
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-180746 Nuclear import of Rev protein
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-211000 Gene Silencing by RNA
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-556833 Metabolism of lipids
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663205 Infectious disease
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68882 Mitotic Anaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-72306 tRNA processing
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953854 Metabolism of RNA
R-HSA-8957322 Metabolism of steroids
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0004059 BXGD000250 aspirin intolerance
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022548 BXGD001551 Keloid Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033300 BXGD002403 Progeria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0035288 BXGD002524 Reticuloendotheliosis, X-linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0149940 BXGD003391 Sciatic Neuropathy Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476254 BXGD008984 Dyslexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677898 BXGD009735 invasive cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837454 BXGD014232 SPINOCEREBELLAR ATAXIA 8 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1839259 BXGD014363 Bulbo-Spinal Atrophy, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1839780 BXGD014405 FRAGILE X TREMOR/ATAXIA SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1861736 BXGD016072 SPINOCEREBELLAR ATAXIA 31 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2745963 BXGD017571 Kashin-Beck Disease Musculoskeletal Diseases
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000436 Glycerol 92.09
BXGC0000556 1H-Imidazole-1-acetic acid 126.11
BXGC0000651 Harmalan 184.24
BXGC0000999 Peucedanin 258.27
BXGC0001325 Progesterone 314.46
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0001544 Harmaline 214.26
BXGC0001782 Sennoside B 862.74
BXGC0001876 Chrysoeriol 300.26
BXGC0002052 Aesculetin 178.14
BXGC0002061 Aloeemodin 270.24
BXGC0002064 Amentoflavone 538.46
BXGC0002588 Magnesium 24.31
BXGC0002690 alpha-Catechin 290.27
BXGC0002722 Nitrate 62
BXGC0003705 Chloride 35.45
BXGC0003992 Imidazoleacrylic acid 138.12
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0005017 4,7-Dihydroxy-2H-1-benzopyran-2-one 178.14
BXGC0005049 4-Methylumbelliferyl acetate 218.21
BXGC0005319 Garcinone E 464.55
BXGC0005497 Syringin 372.37
BXGC0005721 Bisdemethoxycurcumin 308.33
BXGC0005915 Formononetin 268.27
BXGC0005982 Curcumin 368.38
BXGC0006291 Scopoletin 192.17
BXGC0006367 Mangiferin 422.34
BXGC0006635 Luteolin 286.24
BXGC0008824 Astragalin 448.38
BXGC0012321 Menatetrenone 444.66
BXGC0012651 Schizandrin 432.21
BXGC0012874 Continentalic acid 302.22
BXGC0013068 3-(4-Hydroxyphenyl)-6-Methoxy-7-[3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-4-One 446.12
BXGC0013582 Curcumin 368.13
BXGC0014870 4,5-Dimethoxy-11-Methyl-[1,3]Dioxolo[4,5-C]Acridin-6-One 313.1
BXGC0017158 thunberginol A 270.05
BXGC0017757 Androstenedione 286.19
BXGC0017933 Sulfuretin 270.05
BXGC0020311 Melicopidine 313.1
BXGC0020578 7alpha-Hydroxy-EPIA 306.22
BXGC0020756 4-(1,3-Benzothiazol-2-Yl)-2-Methylaniline 240.07
BXGC0020995 6-[(3E,5E,7S)-5,7-Dimethyl-2-Oxonona-3,5-Dienyl]-2,4-Dihydroxy-3-Methylbenzaldehyde 316.17
BXGC0021255 4-[(3S)-8,8-Dimethyl-3,4-Dihydro-2H-Pyrano[2,3-F]Chromen-3-Yl]Benzene-1,3-Diol 324.14
BXGC0021553 Perillic Acid 166.1
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
BXGC0022806 1-(5-Thiophen-2-Ylthiophen-2-Yl)Ethanone 208
BXGC0022865 (2S)-2-Hydroxy-2-Phenylacetic Acid 152.05
BXGC0023488 ginkgolide A 408.14
BXGC0023872 Adenine 135.05
BXGC0024141 Hydrocortisone 362.21
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024489 Licarin A 326.15
BXGC0024813 Demethoxycurcumin 338.12
BXGC0025386 Gitoxin 780.43
BXGC0025876 Acetoside 624.21
BXGC0026607 epiberberine 336.12
BXGC0026973 3-(3,4-Dimethoxyphenyl)propionic acid 210.09
BXGC0028036 Esculin hydrate 340.08
BXGC0028067 Enniatin B 639.41
BXGC0028104 Hyoscyamine 289.17
BXGC0028113 Fraxine 370.09
BXGC0029320 geniposide 388.14
BXGC0029721 Sclerotiorin 390.12
BXGC0031067 6,7-Dimethoxy-3H-2-Benzofuran-1-One 194.06
BXGC0031642 alpha-Tocopherol 472.39
BXGC0031733 (24S)-6alpha-(2-O-alpha-L-Rhamnopyranosyl-6-O-acetyl-beta-D-glucopyranosyloxy)-20,24-epoxydammarane-3beta,12beta,25-triol 842.5
BXGC0031881 4-methoxy-5-hydroxycanthin-6-one 266.07
BXGC0031951 Aristolochic D 357.05
BXGC0032061 Methylmalonic Acid 118.03
BXGC0034968 Dienestrol 266.13
BXGC0035776 BRUCEOLIDE 438.15
BXGC0036864 Cyclovalone 366.15
BXGC0038066 Rescinnamine 634.29
BXGC0038197 2-Methoxyphenazine 210.08
BXGC0038233 Nalidixic Acid 232.08
BXGC0038660 Tenulin 306.15
BXGC0039172 Oxyresveratrol 244.07
BXGC0040936 Sid26657808 284.07
BXGC0041896 (2R,3R,4R)-2-(Hydroxymethyl)Pyrrolidine-3,4-Diol 133.07
BXGC0042035 raubasine 352.18
BXGC0042256 1,4-Bis[[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxy]-3,5-Dihydroxycyclohexane-1-Carboxylic Acid 516.13
BXGC0042336 7-Amino-4-Hydroxynaphthalene-2-Sulfonic Acid 239.03
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042397 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-Methyl-2,3-Dihydrochromen-4-One 286.08
BXGC0044857 Sp-600125 220.06
BXGC0046862 Benzo[Def]Chrysene 252.09
BXGC0047692 Gefitinib 446.15
BXGC0047871 7-Hydroxyflavone 238.06
BXGC0048845 Guanosine Triphosphate 522.99
BXGC0050284 10-Hydroxycamptothecin 364.11
BXGC0050877 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-Dihydro-2H-Chromene-3,5,7-Triol;Hydrate 290.08
BXGC0051082 4-Hydroxy-2-methoxybenzaldehyde 152.05
BXGC0052370 ginkgolide C 440.13
BXGC0052374 Reserpine 608.27
BXGC0052878 Bisphenol A 228.12
BXGC0053235 Fraxetin 208.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein