Showing entry for Glycogen phosphorylase, liver form


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006492
Protein NameGlycogen phosphorylase, liver form
Uniport IdP06737
GenePYGL
Gene Id5836
DomainPhosphorylase
Pfam PF00343  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00500 Starch and sucrose metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0070266 necroptotic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0009617 response to bacterium
molecular function GO:0016208 AMP binding
molecular function GO:0005524 ATP binding
molecular function GO:0032052 bile acid binding
molecular function GO:0008144 drug binding
molecular function GO:0005536 glucose binding
molecular function GO:0008184 glycogen phosphorylase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0102250 linear malto-oligosaccharide phosphorylase activity
molecular function GO:0002060 purine nucleobase binding
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0102499 SHG alpha-glucan phosphorylase activity
molecular function GO:0019842 vitamin binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8982491 Glycogen metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0017495 BXGD001111 Gerstmann-Straussler-Scheinker Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections; Nervous System Diseases
C0017919 BXGD001150 Glycogen Storage Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017920 BXGD001151 Glycogen Storage Disease Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017922 BXGD001153 Glycogen Storage Disease Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017924 BXGD001155 Glycogen Storage Disease Type V Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017925 BXGD001156 Glycogen Storage Disease Type VI Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0029438 BXGD002148 Massive Osteolyses Musculoskeletal Diseases
C0268147 BXGD005837 Glycogen storage disease, type IX Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271708 BXGD006244 Fasting Hypoglycemia Nutritional and Metabolic Diseases
C0337443 BXGD007161 Sodium measurement
C0349588 BXGD007933 Short stature
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1848701 BXGD014967 Elevated hepatic transaminase
C1856285 BXGD015592 Increased hepatic glycogen content
C1859778 BXGD015931 Postnatal growth retardation
C1867873 BXGD016473 Failure to thrive in infancy
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919142 BXGD017867 Short Stature, CTCAE
C2985280 BXGD018223 Blood Protein Measurement
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3896673 BXGD020041 Familial Nonmedullary Thyroid Gland Carcinoma
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0005683 Quercetin 302.24
BXGC0005869 Riboflavine 376.36
BXGC0008062 Uric acid 168.11
BXGC0024261 Adenosine Phosphate 347.06
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0041896 (2R,3R,4R)-2-(Hydroxymethyl)Pyrrolidine-3,4-Diol 133.07
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0043088 Pyridoxal Phosphate 247.02
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein