Showing entry for acetohydroxamic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0042270
Compound Nameacetohydroxamic acid
Structure
FormulaC2H5NO2
InchiKeyRRUDCFGSUDOHDG-UHFFFAOYSA-N
SMILESON=C(O)C
InchiInChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
IUPACN-hydroxyacetamide
Molecular Weight75.03
Pubchem Id1990
Chembl IdCHEMBL734
Targets of Information Source
DrugBank DB00551
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P18314 BXGT008397 Urease subunit alpha reviewed - ureC approved inhibitor
P39900 BXGT010148 Macrophage metalloelastase reviewed Enzyme MMP12 approved inhibitor
PDB HAE
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00918 BXGT005690 Carbonic anhydrase 2 reviewed CA2 - - 47000 - -
P69996 BXGT011656 Urease subunit beta reviewed ureB - - - - -
P18314 BXGT008397 Urease subunit alpha reviewed ureC - - - - -
P39900 BXGT010148 Macrophage metalloelastase reviewed MMP12 Enzyme - - - -
P08254 BXGT006758 Stromelysin-1 reviewed MMP3 Enzyme - - - -
P39900 BXGT010148 Macrophage metalloelastase reviewed MMP12 Enzyme - - 8000000 -
P45452 BXGT010462 Collagenase 3 reviewed MMP13 Enzyme - - - -
P22894 BXGT008815 Neutrophil collagenase reviewed MMP8 Enzyme - - - -
P07374 BXGT006615 Urease reviewed - - - - -
P41020 BXGT010218 Urease subunit alpha reviewed ureC - 2600 - - -
P0ABE7 BXGT007229 Soluble cytochrome b562 reviewed cybC - - - - -
Binding DB 50099857
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008066 Urease subunit alpha reviewed ureA - 120000 - -
reviewed BXGT011614 Peptide deformylase reviewed def - >100000 - -
reviewed BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 - - 17000000 -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 - 47000 - -
reviewed BXGT006615 Urease reviewed - - 17300 - -
reviewed BXGT006615 Urease reviewed - - 42000 - -
reviewed BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 - 625000 - -
reviewed BXGT008169 Lethal factor reviewed lef - 11400000 - -
reviewed BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 - 15000000 - -
reviewed BXGT010429 Succinyl-diaminopimelate desuccinylase reviewed dapE - >1000000 - -
reviewed BXGT006615 Urease reviewed - - 41500 - -
CHEMBL CHEMBL734
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P68825 BXGT011613 Peptide deformylase reviewed - def IC50 '>' 100000 nM
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Inhibition '=' -12 %
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 18400 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 18400 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 100600 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 100600 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA Inhibition '=' 91 %
P69996 BXGT011656 Urease subunit beta reviewed - ureB Inhibition '=' 91 %
P14916 BXGT008066 Urease subunit alpha reviewed - ureA Inhibition '=' 85 %
P69996 BXGT011656 Urease subunit beta reviewed - ureB Inhibition '=' 85 %
P45452 BXGT010462 Collagenase 3 reviewed Enzyme MMP13 IC50 - - -
P08254 BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 Inhibition '=' 5 %
Q9QZX7 BXGT021400 Serine racemase reviewed - Srr Inhibition - - -
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A Ki - - -
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 17000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 17000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 91 %
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Inhibition '=' 10 %
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 '=' 47000 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 '=' 625000 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 19000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 19000 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 18200 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 18200 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Inhibition '=' 4 %
P22894 BXGT008815 Neutrophil collagenase reviewed Enzyme MMP8 Inhibition '=' 5 %
P07374 BXGT006615 Urease reviewed - IC50 '=' 17300 nM
P08254 BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 Kd '=' 17000000 nM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki - - -
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 104800 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 104800 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 1678 nM
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 Inhibition '=' 4 %
P15917 BXGT008169 Lethal factor reviewed - lef Inhibition '=' 25 %
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 IC50 '=' 15000000 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 11000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 11000 nM
P41245 BXGT010243 Matrix metalloproteinase-9 reviewed - Mmp9 Inhibition '<' 5 %
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 17200 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 17200 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA Inhibition '=' 94 %
P69996 BXGT011656 Urease subunit beta reviewed - ureB Inhibition '=' 94 %
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' -97 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 56 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 18000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 18000 nM
P39900 BXGT010148 Macrophage metalloelastase reviewed Enzyme MMP12 Kd '=' 6180000 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 110000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 110000 nM
P15917 BXGT008169 Lethal factor reviewed - lef IC50 '=' 11400000 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 35481 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 27600 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 27600 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 100 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' -2 %
P45452 BXGT010462 Collagenase 3 reviewed Enzyme MMP13 Kb '=' 1200 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 5956 nM
P07374 BXGT006615 Urease reviewed - IC50 '=' 42000 nM
P44514 BXGT010429 Succinyl-diaminopimelate desuccinylase reviewed - dapE IC50 '>' 1000000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 31622 nM
P07374 BXGT006615 Urease reviewed - IC50 '=' 41500 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 27900 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 27900 nM
Q0PXQ5 BXGT026092 Urease subunit beta unreviewed - ureB IC50 '=' 17200 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 46270 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 46270 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 108000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 108000 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA Ratio IC50 '=' 46 -
P69996 BXGT011656 Urease subunit beta reviewed - ureB Ratio IC50 '=' 46 -
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 172000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 172000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF05203 Chlamydomonas reinhardtii Chlamydomonas reinhardtii Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease