Showing entry for Sporadic Breast Carcinoma


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD012828
Disease NameSporadic Breast Carcinoma
Disease CUI IdC1336076
MeSH Codes C04   C17  
Disease Class NameNeoplasms; Skin and Connective Tissue Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00591 BXGT003939 Gamma-aminobutyric acid receptor subunit pi 2568 reviewed Ion channel
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O15527 BXGT004176 N-glycosylase/DNA lyase 4968 reviewed
O43570 BXGT004601 Carbonic anhydrase 12 771 reviewed
O43708 BXGT004617 Maleylacetoacetate isomerase 2954 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00352 BXGT005510 Retinal dehydrogenase 1 216 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03897 BXGT006111 NADH-ubiquinone oxidoreductase chain 3 4537 reviewed
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04278 BXGT006182 Sex hormone-binding globulin 6462 reviewed
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P06276 BXGT006430 Cholinesterase 590 reviewed
P06401 BXGT006436 Progesterone receptor 5241 reviewed Nuclear receptor
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P10827 BXGT007623 Thyroid hormone receptor alpha 7067 reviewed Nuclear receptor
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12830 BXGT007852 Cadherin-1 999 reviewed
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 3292 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16442 BXGT008227 Histo-blood group ABO system transferase 28 reviewed Enzyme
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P25963 BXGT009080 NF-kappa-B inhibitor alpha 4792 reviewed
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30279 BXGT009415 G1/S-specific cyclin-D2 894 reviewed Enzyme modulator
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37059 BXGT009957 Estradiol 17-beta-dehydrogenase 2 3294 reviewed Enzyme
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P39060 BXGT010088 Collagen alpha-1(XVIII) chain 80781 reviewed
P39900 BXGT010148 Macrophage metalloelastase 4321 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P41440 BXGT010261 Folate transporter 1 6573 reviewed Transporter
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43115 BXGT010356 Prostaglandin E2 receptor EP3 subtype 5733 reviewed G-protein coupled receptor
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P52701 BXGT010943 DNA mismatch repair protein Msh6 2956 reviewed Nucleic acid binding
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P54760 BXGT011075 Ephrin type-B receptor 4 2050 reviewed Kinase
P56937 BXGT011205 3-keto-steroid reductase 51478 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61769 BXGT011383 Beta-2-microglobulin 567 reviewed Immune response
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q6UWP2 BXGT016567 Dehydrogenase/reductase SDR family member 11 79154 reviewed Enzyme
Q7Z7D3 BXGT017262 V-set domain-containing T-cell activation inhibitor 1 79679 reviewed Enzyme modulator
Q86YC2 BXGT017633 Partner and localizer of BRCA2 79728 reviewed
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 51548 reviewed Epigenetic regulator
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92956 BXGT019399 Tumor necrosis factor receptor superfamily member 14 8764 reviewed
Q96PD4 BXGT019705 Interleukin-17F 112744 reviewed
Q96RL1 BXGT019730 BRCA1-A complex subunit RAP80 51720 reviewed
Q96T88 BXGT019747 E3 ubiquitin-protein ligase UHRF1 29128 reviewed
Q99728 BXGT019956 BRCA1-associated RING domain protein 1 580 reviewed
Q9NW38 BXGT021230 E3 ubiquitin-protein ligase FANCL 55120 reviewed Enzyme
Q9UBB5 BXGT021649 Methyl-CpG-binding domain protein 2 8932 reviewed Epigenetic regulator
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y316 BXGT022252 Protein MEMO1 51072 reviewed
Q9Y5W5 BXGT022303 Wnt inhibitory factor 1 11197 reviewed Calcium-binding protein
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P29590 BXGT024350 Protein PML 5371 reviewed
P16104 BXGT024571 Histone H2AX 3014 reviewed Nucleic acid binding
Q7Z6A9 BXGT025024 B- and T-lymphocyte attenuator 151888 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease