Showing entry for Tumor necrosis factor receptor superfamily member 14


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019399
Protein NameTumor necrosis factor receptor superfamily member 14
Uniport IdQ92956
GeneTNFRSF14
Gene Id8764
DomainTNFR_c6
Pfam PF00020  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0006955 immune response
Biological Process GO:0045087 innate immune response
Biological Process GO:1905675 negative regulation of adaptive immune memory response
Biological Process GO:0046642 negative regulation of alpha-beta T cell proliferation
Biological Process GO:0002720 positive regulation of cytokine production involved in immune response
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:2000406 positive regulation of T cell migration
Biological Process GO:0031295 T cell costimulation
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
molecular function GO:0019955 cytokine binding
molecular function GO:0005031 tumor necrosis factor-activated receptor activity
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0001618 virus receptor activity
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-388841 Costimulation by the CD28 family
R-HSA-388841 Costimulation by the CD28 family
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5669034 TNFs bind their physiological receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010034 BXGD000640 Corneal Diseases Eye Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015403 BXGD000985 Eye Infection Infections; Eye Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019340 BXGD001321 Herpes NOS Infections
C0019345 BXGD001324 Herpes Labialis Infections; Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019357 BXGD001326 Keratitis, Herpetic Infections; Eye Diseases
C0019372 BXGD001329 Herpesviridae Infections Infections
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024534 BXGD001784 Malaria, Cerebral Infections; Nervous System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0033839 BXGD002434 Pseudorabies Infections; Nervous System Diseases; Animal Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034735 BXGD002487 Raynaud Phenomenon Cardiovascular Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948192 BXGD011514 Primary infection NOS
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333171 BXGD012603 Primary Cutaneous Follicle Center Lymphoma
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1336076 BXGD012828 Sporadic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1707516 BXGD013589 Corneal Sensitivity
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2698750 BXGD017456 Pediatric follicular lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2931185 BXGD017970 Neonatal herpes Female Urogenital Diseases and Pregnancy Complications; Infections; Skin and Connective Tissue Diseases
C3160909 BXGD018497 Autoimmune arthritis
C3714514 BXGD019409 Infection Infections
C4048329 BXGD021904 Immunosuppression
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein