Showing entry for Estradiol 17-beta-dehydrogenase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009957
Protein NameEstradiol 17-beta-dehydrogenase 2
Uniport IdP37059
GeneHSD17B2
Gene Id3294
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006703 estrogen biosynthetic process
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001890 placenta development
Biological Process GO:0032526 response to retinoic acid
molecular function GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
molecular function GO:0004303 estradiol 17-beta-dehydrogenase activity
molecular function GO:0047035 testosterone dehydrogenase (NAD+) activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-193144 Estrogen biosynthesis
R-HSA-196071 Metabolism of steroid hormones
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0018916 BXGD001245 Hemangioma Neoplasms
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0342513 BXGD007494 Idiopathic hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1336076 BXGD012828 Sporadic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1336905 BXGD012873 Endometrial Endometrioid Adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3539781 BXGD019086 Progressive cGVHD
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000016 Butein 272.25
BXGC0000031 Jaceosidin 330.29
BXGC0000340 Kaempferol 286.24
BXGC0000383 (S)-Naringenin 272.25
BXGC0000430 Gossypol 518.55
BXGC0001899 Daidzein 254.24
BXGC0001962 Hesperetin 302.28
BXGC0002071 Apigenin 270.24
BXGC0002781 Flavonoids 224.25
BXGC0003776 Flavones 222.24
BXGC0005624 Genistein 270.24
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005683 Quercetin 302.24
BXGC0005919 Biochanin A 284.27
BXGC0005945 2'-Hydroxygenistein 286.24
BXGC0005982 Curcumin 368.38
BXGC0006362 Estrone 270.37
BXGC0006466 Oleanolic acid 456.71
BXGC0008167 Chrysin 254.24
BXGC0008707 Isoliquiritigenin 256.25
BXGC0009332 Pelanin 356.5
BXGC0011627 Glycyrrhetic acid 470.69
BXGC0017670 1,3,8-Trihydroxy-[1]Benzofuro[2,3-B]Chromen-11-One 284.03
BXGC0030304 4,4'-((1S,3Ar,4S,6Ar)-Hexahydrofuro[3,4-C]Furan-1,4-Diyl)Bis(2-Methoxyphenol) 358.14
BXGC0032282 (-)-Dihydroguaiareticacid 330.18
BXGC0047871 7-Hydroxyflavone 238.06
BXGC0048313 Rosmarinic Acid 360.08
BXGC0050317 Acetoxolone 512.35
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein