Showing entry for Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003920
Protein NamePhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Uniport IdO00443
GenePIK3C2A
Gene Id5286
DomainC2; PI3Ka; PI3K_C2; PI3K_rbd; PI3_PI4_kinase; PX
Pfam PF00168   PF00454   PF00792   PF00794   PF00613   PF00787  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016477 cell migration
Biological Process GO:0048268 clathrin coat assembly
Biological Process GO:0006897 endocytosis
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0006887 exocytosis
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0061024 membrane organization
Biological Process GO:0014065 phosphatidylinositol 3-kinase signaling
Biological Process GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0046854 phosphatidylinositol phosphorylation
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0010508 positive regulation of autophagy
Biological Process GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
Biological Process GO:0014829 vascular associated smooth muscle contraction
molecular function GO:0016303 1-phosphatidylinositol-3-kinase activity
molecular function GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0035004 phosphatidylinositol 3-kinase activity
molecular function GO:0035091 phosphatidylinositol binding
molecular function GO:0052742 phosphatidylinositol kinase activity
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005942 phosphatidylinositol 3-kinase complex
cellular component GO:0005886 plasma membrane
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-556833 Metabolism of lipids
R-HSA-5653656 Vesicle-mediated transport
R-HSA-8856828 Clathrin-mediated endocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000744 BXGD000006 Abetalipoproteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004604 BXGD000278 Back Pain Pathological Conditions, Signs and Symptoms
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020437 BXGD001381 Hypercalcemia Nutritional and Metabolic Diseases
C0020438 BXGD001382 Hypercalciuria Pathological Conditions, Signs and Symptoms
C0020598 BXGD001440 Hypocalcemia Nutritional and Metabolic Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027849 BXGD002049 Neuroleptic Malignant Syndrome Nervous System Diseases; Chemically-Induced Disorders
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033680 BXGD002414 Protein-Losing Enteropathies Digestive System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0085681 BXGD003237 Hyperphosphatemia (disorder) Nutritional and Metabolic Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242287 BXGD005145 Isaacs syndrome Musculoskeletal Diseases; Nervous System Diseases
C0302511 BXGD006849 Small for gestational age fetus Pathological Conditions, Signs and Symptoms
C0349588 BXGD007933 Short stature
C0398568 BXGD008194 Blood group deletion syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0409338 BXGD008381 Flexion contracture - elbow
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0541764 BXGD009259 Delayed bone age
C0557874 BXGD009444 Global developmental delay
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0687751 BXGD009845 Acanthocytosis Hemic and Lymphatic Diseases
C0751336 BXGD010392 Distal Muscular Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0871470 BXGD011316 Systolic Pressure
C1184919 BXGD011799 Thoracic kyphosis Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1836184 BXGD014088 Short femoral neck
C1836230 BXGD014099 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
C1836231 BXGD014100 HIV-1, RESISTANCE TO
C1836232 BXGD014101 ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
C1836233 BXGD014102 AIDS, PROGRESSION TO
C1837482 BXGD014237 Thoracic hypoplasia
C1842366 BXGD014512 Low anterior hairline
C1843920 BXGD014619 COENZYME Q10 DEFICIENCY Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1849367 BXGD015046 Nasal bridge wide
C1855728 BXGD015536 Low posterior hairline
C1860493 BXGD015987 Abnormality of the sternum
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2919142 BXGD017867 Short Stature, CTCAE
C4024726 BXGD021387 Mucopolysacchariduria
C4082304 BXGD022090 Oligodontia
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000140 Phytic acid 660.04
BXGC0000436 Glycerol 92.09
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein