adisease

Showing entry for Myeloid Leukemia

General Disease Information
BXGD Id	BXGD001659
Disease Name	Myeloid Leukemia
Disease CUI Id	C0023470
MeSH Codes	C04
Disease Class Name	Neoplasms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0002715 HP:0002664 HP:0001871
Human Phenotype Ontology Term	Abnormality of the immune system; Neoplasm; Abnormality of blood and blood-forming tissues
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00443	BXGT003920	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	5286	reviewed	Kinase
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14786	BXGT004099	Neuropilin-1	8829	reviewed
O15350	BXGT004154	Tumor protein p73	7161	reviewed	Transcription factor
O15392	BXGT004162	Baculoviral IAP repeat-containing protein 5	332	reviewed	Enzyme modulator
O43913	BXGT004634	Origin recognition complex subunit 5	5001	reviewed	Nucleic acid binding
O60462	BXGT004876	Neuropilin-2	8828	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75365	BXGT005115	Protein tyrosine phosphatase type IVA 3	11156	reviewed
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
O95235	BXGT005360	Kinesin-like protein KIF20A	10112	reviewed	Cellular structure
P00488	BXGT005552	Coagulation factor XIII A chain	2162	reviewed	Enzyme
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05160	BXGT006330	Coagulation factor XIII B chain	2165	reviewed
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P07332	BXGT006601	Tyrosine-protein kinase Fes/Fps	2242	reviewed	Kinase
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P08700	BXGT006816	Interleukin-3	3562	reviewed
P0DP23	BXGT007520	Calmodulin-1	808	reviewed
P0DP24	BXGT007521	Calmodulin-2	808	reviewed
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11309	BXGT007685	Serine/threonine-protein kinase pim-1	5292	reviewed	Kinase
P11926	BXGT007760	Ornithine decarboxylase	4953	reviewed	Enzyme
P12724	BXGT007837	Eosinophil cationic protein	6037	reviewed
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15151	BXGT008089	Poliovirus receptor	5817	reviewed
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17676	BXGT008327	CCAAT/enhancer-binding protein beta	1051	reviewed	Transcription factor
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P20815	BXGT008604	Cytochrome P450 3A5	1577	reviewed	Enzyme
P22830	BXGT008809	Ferrochelatase, mitochondrial	2235	reviewed	Enzyme
P24158	BXGT008951	Myeloblastin	5657	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P25791	BXGT009072	Rhombotin-2	4005	reviewed
P26951	BXGT009147	Interleukin-3 receptor subunit alpha	3563	reviewed	Signaling
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28072	BXGT009231	Proteasome subunit beta type-6	5694	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28562	BXGT009270	Dual specificity protein phosphatase 1	1843	reviewed
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P30530	BXGT009431	Tyrosine-protein kinase receptor UFO	558	reviewed	Kinase
P31260	BXGT009519	Homeobox protein Hox-A10	3206	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35658	BXGT009859	Nuclear pore complex protein Nup214	8021	reviewed	Nucleic acid binding
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41231	BXGT010240	P2Y purinoceptor 2	5029	reviewed	G-protein coupled receptor
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42684	BXGT010331	Tyrosine-protein kinase ABL2	27	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P47900	BXGT010595	P2Y purinoceptor 1	5028	reviewed	G-protein coupled receptor
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P51575	BXGT010861	P2X purinoceptor 1	5023	reviewed	Ion channel
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P52333	BXGT010928	Tyrosine-protein kinase JAK3	3718	reviewed	Kinase
P54687	BXGT011067	Branched-chain-amino-acid aminotransferase, cytosolic	586	reviewed	Enzyme
P56373	BXGT011164	P2X purinoceptor 3	5024	reviewed	Ion channel
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P69891	BXGT011646	Hemoglobin subunit gamma-1	3047	reviewed
P69892	BXGT011647	Hemoglobin subunit gamma-2	3048	reviewed
P78344	BXGT011835	Eukaryotic translation initiation factor 4 gamma 2	1982	reviewed	Nucleic acid binding
P78358	BXGT011838	Cancer/testis antigen 1	246100	reviewed
P78504	BXGT011844	Protein jagged-1	182	reviewed
P83916	BXGT012025	Chromobox protein homolog 1	10951	reviewed	Epigenetic regulator
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q02763	BXGT012667	Angiopoietin-1 receptor	7010	reviewed	Kinase
Q02880	BXGT012677	DNA topoisomerase 2-beta	7155	reviewed
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q04917	BXGT012791	14-3-3 protein eta	7533	reviewed	Chaperone
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q07889	BXGT012946	Son of sevenless homolog 1	6654	reviewed	Enzyme modulator
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q13555	BXGT013375	Calcium/calmodulin-dependent protein kinase type II subunit gamma	818	reviewed	Kinase
Q13951	BXGT013407	Core-binding factor subunit beta	865	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q59FK2	BXGT015276	Selenocysteine lyase variant	51540	unreviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q7LBC6	BXGT016998	Lysine-specific demethylase 3B	51780	reviewed	Epigenetic regulator
Q86U44	BXGT017610	N6-adenosine-methyltransferase catalytic subunit	56339	reviewed
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q92692	BXGT019361	Nectin-2	5819	reviewed
Q92769	BXGT019370	Histone deacetylase 2	3066	reviewed	Epigenetic regulator
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96I15	BXGT019674	Selenocysteine lyase	51540	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99593	BXGT019939	T-box transcription factor TBX5	6910	reviewed	Transcription factor
Q99683	BXGT019947	Mitogen-activated protein kinase kinase kinase 5	4217	reviewed	Kinase
Q9BZL6	BXGT020199	Serine/threonine-protein kinase D2	25865	reviewed	Kinase
Q9UBL9	BXGT021656	P2X purinoceptor 2	22953	reviewed	Ion channel
Q9UJU2	BXGT021730	Lymphoid enhancer-binding factor 1	51176	reviewed
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UKV8	BXGT021752	Protein argonaute-2	27161	reviewed
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UN36	BXGT021780	Protein NDRG2	57447	reviewed	Enzyme
Q9Y286	BXGT022225	Sialic acid-binding Ig-like lectin 7	27036	reviewed	Receptor
Q9Y468	BXGT022270	Lethal(3)malignant brain tumor-like protein 1	26013	reviewed	Epigenetic regulator
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
P20138	BXGT023857	Myeloid cell surface antigen CD33	945	reviewed	Receptor
Q13007	BXGT023883	Interleukin-24	11009	reviewed
Q13185	BXGT024241	Chromobox protein homolog 3	11335	reviewed	Epigenetic regulator
P29590	BXGT024350	Protein PML	5371	reviewed
P0DP25	BXGT024595	Calmodulin-3	808	reviewed
P38646	BXGT024954	Stress-70 protein, mitochondrial	3313	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q99435	BXGT025240	Protein kinase C-binding protein NELL2	4753	reviewed	Calcium-binding protein
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed
Q9UKB1	BXGT025928	F-box/WD repeat-containing protein 11	23291	reviewed
Q96AE4	BXGT025980	Far upstream element-binding protein 1	8880	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}