Showing entry for Muscular Dystrophy, Duchenne


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD000808
Disease NameMuscular Dystrophy, Duchenne
Disease CUI IdC0013264
MeSH Codes C16   C05   C10  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00443 BXGT003920 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 5286 reviewed Kinase
O00755 BXGT003945 Protein Wnt-7a 7476 reviewed Signaling
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14788 BXGT004100 Tumor necrosis factor ligand superfamily member 11 8600 reviewed Signaling
O14924 BXGT004111 Regulator of G-protein signaling 12 6002 reviewed
O15054 BXGT004121 Lysine-specific demethylase 6B 23135 reviewed Epigenetic regulator
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 4864 reviewed Transporter
O43157 BXGT004572 Plexin-B1 5364 reviewed
O60488 BXGT004878 Long-chain-fatty-acid--CoA ligase 4 2182 reviewed Enzyme
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75923 BXGT005166 Dysferlin 8291 reviewed Transporter
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
P00374 BXGT005520 Dihydrofolate reductase 1719 reviewed Enzyme
P00439 BXGT005539 Phenylalanine-4-hydroxylase 5053 reviewed
P00451 BXGT005545 Coagulation factor VIII 2157 reviewed Enzyme
P00480 BXGT005551 Ornithine carbamoyltransferase, mitochondrial 5009 reviewed
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase 3251 reviewed Enzyme
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01730 BXGT005781 T-cell surface glycoprotein CD4 920 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02144 BXGT005853 Myoglobin 4151 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02818 BXGT005969 Osteocalcin 632 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04632 BXGT006241 Calpain small subunit 1 826 reviewed
P04839 BXGT006273 Cytochrome b-245 heavy chain 1536 reviewed Ion channel
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P07451 BXGT006627 Carbonic anhydrase 3 761 reviewed
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P07711 BXGT006661 Cathepsin L1 1514 reviewed Enzyme
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P07858 BXGT006689 Cathepsin B 1508 reviewed Enzyme
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08648 BXGT006804 Integrin alpha-5 3678 reviewed
P08670 BXGT006810 Vimentin 7431 reviewed
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09238 BXGT006875 Stromelysin-2 4319 reviewed Enzyme
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11308 BXGT007684 Transcriptional regulator ERG 2078 reviewed Transcription factor
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11717 BXGT007740 Cation-independent mannose-6-phosphate receptor 3482 reviewed Receptor
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P13612 BXGT007928 Integrin alpha-4 3676 reviewed
P13688 BXGT007943 Carcinoembryonic antigen-related cell adhesion molecule 1 634 reviewed
P13727 BXGT007951 Bone marrow proteoglycan 5553 reviewed Enzyme modulator
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 3620 reviewed
P15529 BXGT008134 Membrane cofactor protein 4179 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P17252 BXGT008294 Protein kinase C alpha type 5578 reviewed Kinase
P17655 BXGT008325 Calpain-2 catalytic subunit 824 reviewed Enzyme
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 5770 reviewed
P18206 BXGT008389 Vinculin 7414 reviewed
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19429 BXGT008479 Troponin I, cardiac muscle 7137 reviewed Cellular structure
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P20807 BXGT008601 Calpain-3 825 reviewed Enzyme
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21583 BXGT008667 Kit ligand 4254 reviewed
P21817 BXGT008693 Ryanodine receptor 1 6261 reviewed Ion channel
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22352 BXGT008758 Glutathione peroxidase 3 2878 reviewed Enzyme
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P25774 BXGT009066 Cathepsin S 1520 reviewed Enzyme
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A 5141 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30405 BXGT009423 Peptidyl-prolyl cis-trans isomerase F, mitochondrial 10105 reviewed
P30533 BXGT009434 Alpha-2-macroglobulin receptor-associated protein 4043 reviewed
P31415 BXGT009537 Calsequestrin-1 844 reviewed
P35052 BXGT009788 Glypican-1 2817 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43220 BXGT010367 Glucagon-like peptide 1 receptor 2740 reviewed G-protein coupled receptor
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46939 BXGT010555 Utrophin 7402 reviewed
P49662 BXGT010724 Caspase-4 837 reviewed Enzyme
P49759 BXGT010734 Dual specificity protein kinase CLK1 1195 reviewed Kinase
P49908 BXGT010760 Selenoprotein P 6414 reviewed Extracellular structure
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P53634 BXGT011007 Dipeptidyl peptidase 1 1075 reviewed Enzyme
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P63261 BXGT011512 Actin, cytoplasmic 2 71 reviewed Cellular structure
P78504 BXGT011844 Protein jagged-1 182 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01453 BXGT012588 Peripheral myelin protein 22 5376 reviewed Cellular structure
Q01469 BXGT012590 Fatty acid-binding protein 5 2171 reviewed
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta 5467 reviewed Nuclear receptor
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q04759 BXGT012781 Protein kinase C theta type 5588 reviewed Kinase
Q08828 BXGT013008 Adenylate cyclase type 1 107 reviewed
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13705 BXGT013393 Activin receptor type-2B 93 reviewed Kinase
Q14118 BXGT013444 Dystroglycan 1605 reviewed Receptor
Q14573 BXGT013486 Inositol 1,4,5-trisphosphate receptor type 3 3710 reviewed Ion channel
Q14643 BXGT013493 Inositol 1,4,5-trisphosphate receptor type 1 3708 reviewed Ion channel
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q6P589 BXGT016452 Tumor necrosis factor alpha-induced protein 8-like protein 2 79626 reviewed
Q6ZVN8 BXGT016641 Hemojuvelin 148738 reviewed
Q86X55 BXGT017627 Histone-arginine methyltransferase CARM1 10498 reviewed Epigenetic regulator
Q8WZ42 BXGT019023 Titin 7273 reviewed Kinase
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q99572 BXGT019935 P2X purinoceptor 7 5027 reviewed Ion channel
Q99683 BXGT019947 Mitogen-activated protein kinase kinase kinase 5 4217 reviewed Kinase
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BUF5 BXGT020135 Tubulin beta-6 chain 84617 reviewed Cellular structure
Q9BYT8 BXGT020190 Neurolysin, mitochondrial 57486 reviewed Enzyme
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9NYK1 BXGT021258 Toll-like receptor 7 51284 reviewed
Q9UH99 BXGT021693 SUN domain-containing protein 2 25777 reviewed Cellular structure
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UNA0 BXGT021784 A disintegrin and metalloproteinase with thrombospondin motifs 5 11096 reviewed Enzyme
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y5S1 BXGT022300 Transient receptor potential cation channel subfamily V member 2 51393 reviewed Ion channel
Q9Y5X9 BXGT022307 Endothelial lipase 9388 reviewed Enzyme
Q9Y5Y6 BXGT022308 Suppressor of tumorigenicity 14 protein 6768 reviewed Enzyme
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
P35240 BXGT022927 Merlin 4771 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
O14793 BXGT023280 Growth/differentiation factor 8 2660 reviewed Signaling
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P16615 BXGT023653 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 488 reviewed Transporter
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
O43583 BXGT024866 Density-regulated protein 8562 reviewed Enzyme
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
O94901 BXGT025393 SUN domain-containing protein 1 23353 reviewed Cellular structure
Q96RD7 BXGT025890 Pannexin-1 24145 reviewed Ion channel
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease