adisease

Showing entry for Splenomegaly

General Disease Information
BXGD Id	BXGD002723
Disease Name	Splenomegaly
Disease CUI Id	C0038002
MeSH Codes	C23
Disease Class Name	Pathological Conditions, Signs and Symptoms
Semantic Type	Finding
Human Phenotype Ontology Id	HP:0025031 HP:0002715 HP:0001626
Human Phenotype Ontology Term	Abnormality of the digestive system; Abnormality of the immune system; Abnormality of the cardiovascular system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00443	BXGT003920	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	5286	reviewed	Kinase
O00754	BXGT003944	Lysosomal alpha-mannosidase	4125	reviewed
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O14832	BXGT004104	Phytanoyl-CoA dioxygenase, peroxisomal	5264	reviewed
O15120	BXGT004129	1-acyl-sn-glycerol-3-phosphate acyltransferase beta	10555	reviewed
O15357	BXGT004156	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	3636	reviewed
O15553	BXGT004181	Pyrin	4210	reviewed
O15554	BXGT004182	Intermediate conductance calcium-activated potassium channel protein 4	3783	reviewed	Ion channel
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60931	BXGT004911	Cystinosin	1497	reviewed
O95267	BXGT005368	RAS guanyl-releasing protein 1	10125	reviewed	Enzyme modulator
O95342	BXGT005373	Bile salt export pump	8647	reviewed	Transporter
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
P00480	BXGT005551	Ornithine carbamoyltransferase, mitochondrial	5009	reviewed
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P00918	BXGT005690	Carbonic anhydrase 2	760	reviewed
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02549	BXGT005890	Spectrin alpha chain, erythrocytic 1	6708	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02655	BXGT005912	Apolipoprotein C-II	344	reviewed
P02671	BXGT005914	Fibrinogen alpha chain	2243	reviewed
P02730	BXGT005935	Band 3 anion transport protein	6521	reviewed	Transporter
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04066	BXGT006142	Tissue alpha-L-fucosidase	2517	reviewed
P04075	BXGT006145	Fructose-bisphosphate aldolase A	226	reviewed
P04180	BXGT006164	Phosphatidylcholine-sterol acyltransferase	3931	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P06858	BXGT006515	Lipoprotein lipase	4023	reviewed	Enzyme
P07359	BXGT006612	Platelet glycoprotein Ib alpha chain	2811	reviewed	Receptor
P07602	BXGT006646	Prosaposin	5660	reviewed
P08236	BXGT006752	Beta-glucuronidase	2990	reviewed
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P10253	BXGT007550	Lysosomal alpha-glucosidase	2548	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11172	BXGT007665	Uridine 5'-monophosphate synthase	7372	reviewed
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12955	BXGT007865	Xaa-Pro dipeptidase	5184	reviewed	Enzyme
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14598	BXGT008024	Neutrophil cytosol factor 1	653361	reviewed
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15735	BXGT008151	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	5261	reviewed	Kinase
P15848	BXGT008162	Arylsulfatase B	411	reviewed
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16871	BXGT008269	Interleukin-7 receptor subunit alpha	3575	reviewed	Receptor
P16930	BXGT008272	Fumarylacetoacetase	2184	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P19367	BXGT008476	Hexokinase-1	3098	reviewed	Kinase
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21439	BXGT008649	Phosphatidylcholine translocator ABCB4	5244	reviewed	Transporter
P21860	BXGT008698	Receptor tyrosine-protein kinase erbB-3	2065	reviewed	Kinase
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22033	BXGT008721	Methylmalonyl-CoA mutase, mitochondrial	4594	reviewed	Enzyme
P22304	BXGT008752	Iduronate 2-sulfatase	3423	reviewed
P22557	BXGT008783	5-aminolevulinate synthase, erythroid-specific, mitochondrial	212	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24557	BXGT008976	Thromboxane-A synthase	6916	reviewed
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P28070	BXGT009230	Proteasome subunit beta type-4	5692	reviewed
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30613	BXGT009447	Pyruvate kinase PKLR	5313	reviewed	Kinase
P31513	BXGT009546	Dimethylaniline monooxygenase [N-oxide-forming] 3	2328	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31785	BXGT009577	Cytokine receptor common subunit gamma	3561	reviewed	Signaling
P33991	BXGT009745	DNA replication licensing factor MCM4	4173	reviewed	Enzyme
P35052	BXGT009788	Glypican-1	2817	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36551	BXGT009927	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	1371	reviewed	Enzyme
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38571	BXGT010054	Lysosomal acid lipase/cholesteryl ester hydrolase	3988	reviewed	Enzyme
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P43403	BXGT010385	Tyrosine-protein kinase ZAP-70	7535	reviewed	Kinase
P43489	BXGT010394	Tumor necrosis factor receptor superfamily member 4	7293	reviewed
P46019	BXGT010498	Phosphorylase b kinase regulatory subunit alpha, liver isoform	5256	reviewed	Kinase
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P46663	BXGT010531	B1 bradykinin receptor	623	reviewed	G-protein coupled receptor
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P51159	BXGT010839	Ras-related protein Rab-27A	5873	reviewed
P51688	BXGT010883	N-sulphoglucosamine sulphohydrolase	6448	reviewed	Enzyme
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P51857	BXGT010899	Aldo-keto reductase family 1 member D1	6718	reviewed	Enzyme
P51957	BXGT010910	Serine/threonine-protein kinase Nek4	6787	reviewed	Kinase
P54802	BXGT011081	Alpha-N-acetylglucosaminidase	4669	reviewed
P60033	BXGT011286	CD81 antigen	975	reviewed
P60174	BXGT011294	Triosephosphate isomerase	7167	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61626	BXGT011382	Lysozyme C	4069	reviewed
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P69891	BXGT011646	Hemoglobin subunit gamma-1	3047	reviewed
P69892	BXGT011647	Hemoglobin subunit gamma-2	3048	reviewed
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	4791	reviewed	Transcription factor
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q08881	BXGT013012	Tyrosine-protein kinase ITK/TSK	3702	reviewed	Kinase
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13510	BXGT013367	Acid ceramidase	427	reviewed	Enzyme
Q14108	BXGT013440	Lysosome membrane protein 2	950	reviewed	Receptor
Q14376	BXGT013464	UDP-glucose 4-epimerase	2582	reviewed
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15080	BXGT013535	Neutrophil cytosol factor 4	4689	reviewed
Q15392	BXGT013566	Delta(24)-sterol reductase	1718	reviewed	Enzyme
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q658P3	BXGT016142	Metalloreductase STEAP3	55240	reviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q6ZVN8	BXGT016641	Hemojuvelin	148738	reviewed
Q86SX6	BXGT017601	Glutaredoxin-related protein 5, mitochondrial	51218	reviewed	Enzyme
Q8NBK3	BXGT018538	Formylglycine-generating enzyme	285362	reviewed
Q92959	BXGT019400	Solute carrier organic anion transporter family member 2A1	6578	reviewed	Transporter
Q96AX1	BXGT019620	Vacuolar protein sorting-associated protein 33A	65082	reviewed	Transporter
Q96IV0	BXGT019677	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	55768	reviewed	Enzyme
Q96J02	BXGT019679	E3 ubiquitin-protein ligase Itchy homolog	83737	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96RJ3	BXGT019729	Tumor necrosis factor receptor superfamily member 13C	115650	reviewed
Q99519	BXGT019928	Sialidase-1	4758	reviewed	Enzyme
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BQ65	BXGT020107	U6 snRNA phosphodiesterase	79650	reviewed
Q9BQI3	BXGT020113	Eukaryotic translation initiation factor 2-alpha kinase 1	27102	reviewed	Kinase
Q9BXL7	BXGT020171	Caspase recruitment domain-containing protein 11	84433	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9C000	BXGT020206	NACHT, LRR and PYD domains-containing protein 1	22861	reviewed
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9HC97	BXGT020527	G-protein coupled receptor 35	2859	reviewed	G-protein coupled receptor
Q9NRR6	BXGT021193	Phosphatidylinositol polyphosphate 5-phosphatase type IV	56623	reviewed
Q9NZ08	BXGT021266	Endoplasmic reticulum aminopeptidase 1	51752	reviewed	Enzyme
Q9UGI6	BXGT021681	Small conductance calcium-activated potassium channel protein 3	3782	reviewed	Ion channel
Q9Y223	BXGT022207	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	10020	reviewed	Enzyme
Q9Y5X0	BXGT022305	Sorting nexin-10	29887	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
P35670	BXGT023695	Copper-transporting ATPase 2	540	reviewed	Transporter
P15260	BXGT023924	Interferon gamma receptor 1	3459	reviewed	Receptor
P61916	BXGT025881	NPC intracellular cholesterol transporter 2	10577	reviewed
Q96SD1	BXGT025929	Protein artemis	64421	reviewed
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor
P51798	BXGT026083	H(+)/Cl(-) exchange transporter 7	1186	reviewed	Ion channel

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}