Showing entry for Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004872
Protein NamePhosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Uniport IdO60331
GenePIP5K1C
Gene Id23396
DomainPIP5K
Pfam PF01504  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0034333 adherens junction assembly
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0072583 clathrin-dependent endocytosis
Biological Process GO:0061024 membrane organization
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0006909 phagocytosis
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0016079 synaptic vesicle exocytosis
molecular function GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
molecular function GO:0005524 ATP binding
cellular component GO:0005912 adherens junction
cellular component GO:0005829 cytosol
cellular component GO:0010008 endosome membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0005654 nucleoplasm
cellular component GO:0001891 phagocytic cup
cellular component GO:0098793 presynapse
cellular component GO:0032587 ruffle membrane
cellular component GO:0001931 uropod
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-162582 Signal Transduction
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-199991 Membrane Trafficking
R-HSA-373755 Semaphorin interactions
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-422475 Axon guidance
R-HSA-556833 Metabolism of lipids
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0034494 BXGD002481 Rabies (disorder) Infections
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0410916 BXGD008452 Neonatal Death Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0541794 BXGD009262 Skeletal muscle atrophy
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1969655 BXGD016788 LETHAL CONGENITAL CONTRACTURAL SYNDROME 3 Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C3272841 BXGD018637 MUTYH-Associate Polyposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein