Showing entry for Cathepsin L2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004909
Protein NameCathepsin L2
Uniport IdO60911
GeneCTSV
Gene Id1515
DomainInhibitor_I29; Peptidase_C1
Pfam PF08246   PF00112  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0048102 autophagic cell death
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0046697 decidualization
Biological Process GO:0022617 extracellular matrix disassembly
Biological Process GO:0006955 immune response
Biological Process GO:0010259 multicellular organism aging
Biological Process GO:0021675 nerve development
Biological Process GO:0051603 proteolysis involved in cellular protein catabolic process
Biological Process GO:0045616 regulation of keratinocyte differentiation
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0009749 response to glucose
Biological Process GO:0034698 response to gonadotropin
Biological Process GO:1990834 response to odorant
Biological Process GO:0060008 Sertoli cell differentiation
Biological Process GO:0007283 spermatogenesis
molecular function GO:0004177 aminopeptidase activity
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0008234 cysteine-type peptidase activity
molecular function GO:0030984 kininogen binding
molecular function GO:0042277 peptide binding
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0045177 apical part of cell
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005764 lysosome
cellular component GO:0005902 microvillus
cellular component GO:0043005 neuron projection
cellular component GO:0043204 perikaryon
cellular component GO:0030141 secretory granule
Reactome
Pathway Id Pathway Name
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-212436 Generic Transcription Pathway
R-HSA-2132295 MHC class II antigen presentation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0206138 BXGD004158 CREST Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0221228 BXGD004412 Comedone Skin and Connective Tissue Diseases
C0278601 BXGD006547 Inflammatory Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C1266092 BXGD011957 Thymoma, type AB Neoplasms; Hemic and Lymphatic Diseases
C1368683 BXGD012900 Epithelioma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001604 Citrusinine II 287.27
BXGC0001605 Citrusinine I 301.29
BXGC0005055 2-Undecyl-4(1H)-quinolinone 299.45
BXGC0009108 Citbrasine 331.32
BXGC0016811 Pyranofoline 353.13
BXGC0016890 1,3,5-Trihydroxy-2,8-Bis(3-Methylbut-2-Enyl)-10-Methyl-9-Acridone 393.19
BXGC0022067 Glycocitrine-I 325.13
BXGC0038141 1,3,5-Trihydroxy-4-Methoxy-10-Methyl-2,8-Bis(3-Methylbut-2-Enyl)Acridin-9-One 423.2
BXGC0041005 5-Hydroxynoracronycine 323.12
BXGC0050442 Glycocitrine-Iv 355.14
BXGC0053873 ACMC-20bqbz 372.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein