adisease

Showing entry for Myasthenia Gravis

General Disease Information
BXGD Id	BXGD001946
Disease Name	Myasthenia Gravis
Disease CUI Id	C0026896
MeSH Codes	C04 C20 C10
Disease Class Name	Neoplasms; Immune System Diseases; Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00148	BXGT003884	ATP-dependent RNA helicase DDX39A	10212	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00214	BXGT003897	Galectin-8	3964	reviewed	Signaling
O14735	BXGT004088	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	10423	reviewed
O15146	BXGT004131	Muscle, skeletal receptor tyrosine-protein kinase	4593	reviewed	Kinase
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O15553	BXGT004181	Pyrin	4210	reviewed
O60911	BXGT004909	Cathepsin L2	1515	reviewed	Enzyme
O75369	BXGT005119	Filamin-B	2317	reviewed
O75880	BXGT005158	Protein SCO1 homolog, mitochondrial	6341	reviewed	Enzyme
O76054	BXGT005172	SEC14-like protein 2	23541	reviewed
O95255	BXGT005363	Multidrug resistance-associated protein 6	368	reviewed	Transporter
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O95786	BXGT005396	Probable ATP-dependent RNA helicase DDX58	23586	reviewed
O95970	BXGT005409	Leucine-rich glioma-inactivated protein 1	9211	reviewed
P00751	BXGT005643	Complement factor B	629	reviewed
P01031	BXGT005720	Complement C5	727	reviewed	Enzyme modulator
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02708	BXGT005927	Acetylcholine receptor subunit alpha	1134	reviewed	Ion channel
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P06276	BXGT006430	Cholinesterase	590	reviewed
P06681	BXGT006468	Complement C2	717	reviewed
P07451	BXGT006627	Carbonic anhydrase 3	761	reviewed
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08174	BXGT006739	Complement decay-accelerating factor	1604	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08686	BXGT006813	Steroid 21-hydroxylase	1589	reviewed
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P09238	BXGT006875	Stromelysin-2	4319	reviewed	Enzyme
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P0C0L4	BXGT007387	Complement C4-A	721	reviewed
P0C0L5	BXGT007388	Complement C4-B	721	reviewed
P10144	BXGT007541	Granzyme B	3002	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11230	BXGT007677	Acetylcholine receptor subunit beta	1140	reviewed	Ion channel
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13647	BXGT007937	Keratin, type II cytoskeletal 5	3852	reviewed
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15498	BXGT008133	Proto-oncogene vav	7409	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16871	BXGT008269	Interleukin-7 receptor subunit alpha	3575	reviewed	Receptor
P19021	BXGT008449	Peptidyl-glycine alpha-amidating monooxygenase	5066	reviewed	Enzyme
P19971	BXGT008537	Thymidine phosphorylase	1890	reviewed	Enzyme
P20702	BXGT008592	Integrin alpha-X	3687	reviewed
P20815	BXGT008604	Cytochrome P450 3A5	1577	reviewed	Enzyme
P21580	BXGT008666	Tumor necrosis factor alpha-induced protein 3	7128	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25774	BXGT009066	Cathepsin S	1520	reviewed	Enzyme
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30988	BXGT009491	Calcitonin receptor	799	reviewed	G-protein coupled receptor
P35499	BXGT009839	Sodium channel protein type 4 subunit alpha	6329	reviewed	Ion channel
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42262	BXGT010294	Glutamate receptor 2	2891	reviewed	Ion channel
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43489	BXGT010394	Tumor necrosis factor receptor superfamily member 4	7293	reviewed
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46939	BXGT010555	Utrophin	7402	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50135	BXGT010776	Histamine N-methyltransferase	3176	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51679	BXGT010877	C-C chemokine receptor type 4	1233	reviewed	G-protein coupled receptor
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P51686	BXGT010881	C-C chemokine receptor type 9	10803	reviewed	G-protein coupled receptor
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P82251	BXGT011971	b(0,+)-type amino acid transporter 1	11136	reviewed	Transporter
Q01453	BXGT012588	Peripheral myelin protein 22	5376	reviewed	Cellular structure
Q03518	BXGT012723	Antigen peptide transporter 1	6890	reviewed	Transporter
Q04844	BXGT012789	Acetylcholine receptor subunit epsilon	1145	reviewed	Ion channel
Q05315	BXGT012811	Galectin-10	1178	reviewed	Signaling
Q07001	BXGT012907	Acetylcholine receptor subunit delta	1144	reviewed	Ion channel
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q13698	BXGT013392	Voltage-dependent L-type calcium channel subunit alpha-1S	779	reviewed	Ion channel
Q13838	BXGT013397	Spliceosome RNA helicase DDX39B	7919	reviewed
Q14416	BXGT013468	Metabotropic glutamate receptor 2	2912	reviewed	G-protein coupled receptor
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15303	BXGT013557	Receptor tyrosine-protein kinase erbB-4	2066	reviewed	Kinase
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16874	BXGT013685	Cytochrome P450 21-hydroxylase	1589	unreviewed
Q29980	BXGT013981	MHC class I polypeptide-related sequence B	4277	reviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q8WTT0	BXGT018987	C-type lectin domain family 4 member C	170482	reviewed	Receptor
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q96RJ3	BXGT019729	Tumor necrosis factor receptor superfamily member 13C	115650	reviewed
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9NR12	BXGT021174	PDZ and LIM domain protein 7	9260	reviewed	Cellular structure
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NYK1	BXGT021258	Toll-like receptor 7	51284	reviewed
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9P2W7	BXGT021306	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	27087	reviewed	Enzyme
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UBS5	BXGT021662	Gamma-aminobutyric acid type B receptor subunit 1	2550	reviewed	G-protein coupled receptor
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q5JP69	BXGT022691	C3/C5 convertase	717	unreviewed
P20036	BXGT022764	HLA class II histocompatibility antigen, DP alpha 1 chain	3113	reviewed	Immune response
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
P15260	BXGT023924	Interferon gamma receptor 1	3459	reviewed	Receptor
Q96MS0	BXGT025241	Roundabout homolog 3	64221	reviewed	Receptor
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}