adisease

Showing entry for Keratoconus

General Disease Information
BXGD Id	BXGD001557
Disease Name	Keratoconus
Disease CUI Id	C0022578
MeSH Codes	C11
Disease Class Name	Eye Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000478
Human Phenotype Ontology Term	Abnormality of the eye
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O15553	BXGT004181	Pyrin	4210	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60911	BXGT004909	Cathepsin L2	1515	reviewed	Enzyme
O75643	BXGT005142	U5 small nuclear ribonucleoprotein 200 kDa helicase	23020	reviewed
O95237	BXGT005361	Lecithin retinol acyltransferase	9227	reviewed
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02462	BXGT005881	Collagen alpha-1(IV) chain	1282	reviewed
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P03886	BXGT006108	NADH-ubiquinone oxidoreductase chain 1	4535	reviewed	Enzyme
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06703	BXGT006477	Protein S100-A6	6277	reviewed	Calcium-binding protein
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08138	BXGT006729	Tumor necrosis factor receptor superfamily member 16	4804	reviewed	Receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08311	BXGT006762	Cathepsin G	1511	reviewed	Enzyme
P08572	BXGT006791	Collagen alpha-2(IV) chain	1284	reviewed
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P12271	BXGT007786	Retinaldehyde-binding protein 1	6017	reviewed	Transporter
P12273	BXGT007787	Prolactin-inducible protein	5304	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P16499	BXGT008238	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	5145	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P18848	BXGT008432	Cyclic AMP-dependent transcription factor ATF-4	468	reviewed
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19793	BXGT008515	Retinoic acid receptor RXR-alpha	6256	reviewed	Nuclear receptor
P20794	BXGT008600	Serine/threonine-protein kinase MAK	4117	reviewed	Kinase
P20810	BXGT008602	Calpastatin	831	reviewed
P20839	BXGT008608	Inosine-5'-monophosphate dehydrogenase 1	3614	reviewed	Enzyme
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P22748	BXGT008802	Carbonic anhydrase 4	762	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P29034	BXGT009309	Protein S100-A2	6273	reviewed	Calcium-binding protein
P29973	BXGT009389	cGMP-gated cation channel alpha-1	1259	reviewed	Ion channel
P30519	BXGT009429	Heme oxygenase 2	3163	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32926	BXGT009680	Desmoglein-3	1830	reviewed	Cell adhesion
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35913	BXGT009879	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	5158	reviewed
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48506	BXGT010635	Glutamate--cysteine ligase catalytic subunit	2729	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49916	BXGT010764	DNA ligase 3	3980	reviewed	Enzyme
P50213	BXGT010779	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	3419	reviewed	Enzyme
P51955	BXGT010908	Serine/threonine-protein kinase Nek2	4751	reviewed	Kinase
P52569	BXGT010934	Cationic amino acid transporter 2	6542	reviewed	Transporter
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P82279	BXGT011972	Protein crumbs homolog 1	23418	reviewed
Q00059	BXGT012512	Transcription factor A, mitochondrial	7019	reviewed
Q02809	BXGT012674	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	5351	reviewed	Enzyme
Q05315	BXGT012811	Galectin-10	1178	reviewed	Signaling
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q15582	BXGT013581	Transforming growth factor-beta-induced protein ig-h3	7045	reviewed	Signaling
Q15717	BXGT013589	ELAV-like protein 1	1994	reviewed
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16739	BXGT013663	Ceramide glucosyltransferase	7357	reviewed	Enzyme
Q2TB90	BXGT014214	Putative hexokinase HKDC1	80201	reviewed	Kinase
Q56UN5	BXGT015107	Mitogen-activated protein kinase kinase kinase 19	80122	reviewed	Kinase
Q6P2Q9	BXGT016446	Pre-mRNA-processing-splicing factor 8	10594	reviewed	Nucleic acid binding
Q8WWY3	BXGT019006	U4/U6 small nuclear ribonucleoprotein Prp31	26121	reviewed	Nucleic acid binding
Q8WZA1	BXGT019024	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	55624	reviewed
Q92834	BXGT019381	X-linked retinitis pigmentosa GTPase regulator	6103	reviewed
Q92934	BXGT019396	Bcl2-associated agonist of cell death	572	reviewed
Q96FI4	BXGT019658	Endonuclease 8-like 1	79661	reviewed
Q96NR8	BXGT019701	Retinol dehydrogenase 12	145226	reviewed	Enzyme
Q9BZ29	BXGT020195	Dedicator of cytokinesis protein 9	23348	reviewed	Enzyme modulator
Q9H0F7	BXGT020435	ADP-ribosylation factor-like protein 6	84100	reviewed
Q9H4B4	BXGT020474	Serine/threonine-protein kinase PLK3	1263	reviewed	Kinase
Q9H6X2	BXGT020486	Anthrax toxin receptor 1	84168	reviewed	Receptor
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NZN9	BXGT021280	Aryl-hydrocarbon-interacting protein-like 1	23746	reviewed	Chaperone
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y5X4	BXGT022306	Photoreceptor-specific nuclear receptor	10002	reviewed	Nuclear receptor
Q9Y6E0	BXGT022327	Serine/threonine-protein kinase 24	8428	reviewed	Kinase
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q96KN7	BXGT022801	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1	57096	reviewed	Enzyme modulator
Q01955	BXGT023255	Collagen alpha-3(IV) chain	1285	reviewed
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
P56703	BXGT023722	Proto-oncogene Wnt-3	7473	reviewed	Signaling
O43837	BXGT024635	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	3420	reviewed	Enzyme
Q96MS0	BXGT025241	Roundabout homolog 3	64221	reviewed	Receptor
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
O00410	BXGT025968	Importin-5	3843	reviewed	Enzyme modulator
O43172	BXGT026158	U4/U6 small nuclear ribonucleoprotein Prp4	9128	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}