Showing entry for Cpg


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0027925
Compound NameCpg
Structure
FormulaC10H14N5O8P
InchiKeyRQFCJASXJCIDSX-UUOKFMHZSA-N
SMILESO[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1[nH]c(=N)nc2O)COP(=O)(O)O
InchiInChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
IUPAC[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Molecular Weight363.06
Pubchem Id135398631
Chembl IdCHEMBL283807
Targets of Information Source
DrugBank DB01972
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q16774 BXGT013668 Guanylate kinase reviewed Kinase GUK1 experimental -
Q9A5I5 BXGT020039 Response regulator PleD reviewed - pleD experimental -
Q38087 BXGT014334 DNA-directed DNA polymerase reviewed - 43 experimental -
P78352 BXGT011836 Disks large homolog 4 reviewed Receptor DLG4 experimental -
P36959 BXGT009948 GMP reductase 1 reviewed - GMPR experimental -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A experimental -
P49773 BXGT010741 Histidine triad nucleotide-binding protein 1 reviewed Enzyme HINT1 experimental -
P31939 BXGT009584 Bifunctional purine biosynthesis protein PURH reviewed Enzyme ATIC experimental -
P41007 BXGT010216 Bifunctional protein PyrR reviewed - pyrR experimental -
P00497 BXGT005557 Amidophosphoribosyltransferase reviewed - purF experimental -
Q08188 BXGT012965 Protein-glutamine gamma-glutamyltransferase E reviewed Enzyme TGM3 experimental -
P0A9M5 BXGT007194 Xanthine phosphoribosyltransferase reviewed - gpt experimental -
Q05599 BXGT012828 Bifunctional adenosylcobalamin biosynthesis protein CobU reviewed - cobU experimental -
P0AG16 BXGT007360 Amidophosphoribosyltransferase reviewed - purF experimental -
PDB 5GP
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P0A9M5 BXGT007194 Xanthine phosphoribosyltransferase reviewed gpt - - - - -
P00497 BXGT005557 Amidophosphoribosyltransferase reviewed purF - - - - -
Q05599 BXGT012828 Bifunctional adenosylcobalamin biosynthesis protein CobU reviewed cobU - - - - -
P0AG16 BXGT007360 Amidophosphoribosyltransferase reviewed purF - - - - -
P15454 BXGT008129 Guanylate kinase reviewed GUK1 - - - - -
P02994 BXGT006002 Elongation factor 1-alpha reviewed TEF1 - - - - -
P31335 BXGT009524 Bifunctional purine biosynthesis protein PURH reviewed ATIC - - - - -
P0A9M2 BXGT007193 Hypoxanthine phosphoribosyltransferase reviewed hpt - - - - -
P51900 BXGT010904 Hypoxanthine-guanine-xanthine phosphoribosyltransferase reviewed HPT - - - - -
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase reviewed HPRT1 Enzyme - - - -
Q7XZV5 BXGT017225 Ribonuclease NW unreviewed ngr1 - - - - -
P23540 BXGT008881 Ribonuclease MC reviewed - - - - -
P31016 BXGT009499 Disks large homolog 4 reviewed Dlg4 - - - - -
Q64520 BXGT016121 Guanylate kinase reviewed Guk1 - - - - -
P78587 BXGT011851 mRNA-capping enzyme subunit alpha reviewed CGT1 - - - - -
Q9NJI5 BXGT021135 Hypoxanthine phosphoribosyltransferase unreviewed hgprt - - - - -
Q26997 BXGT013923 Hypoxanthine-guanine-xanthine phosphoribosyltransferase reviewed HPRT - - - 7100 -
P00651 BXGT005608 Guanyl-specific ribonuclease T1 reviewed rntA - - - - -
P61823 BXGT011385 Ribonuclease pancreatic reviewed RNASE1 - - - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed PDE5A - - - - -
P11124 BXGT007654 RNA-directed RNA polymerase reviewed P2 - - - - -
Q9SSV1 BXGT021607 RNase NGR3 unreviewed NGR3 - - - - -
Q38087 BXGT014334 DNA-directed DNA polymerase reviewed 43 - - - - -
P41007 BXGT010216 Bifunctional protein PyrR reviewed pyrR - - - - -
P22055 BXGT008723 Genome polyprotein reviewed - - - - -
P9WKE9 BXGT012364 Guanylate kinase reviewed gmk - - - - -
Q81JJ9 BXGT017335 GMP reductase reviewed guaC - - - - -
Q9P2T1 BXGT021305 GMP reductase 2 reviewed GMPR2 - - - - -
P60546 BXGT011314 Guanylate kinase reviewed gmk - - - - -
P32455 BXGT009640 Guanylate-binding protein 1 reviewed GBP1 Enzyme modulator - - - -
P36959 BXGT009948 GMP reductase 1 reviewed GMPR - - - - -
P83749 BXGT012001 Signal recognition particle receptor FtsY reviewed ftsY - - - - -
P42085 BXGT010279 Xanthine phosphoribosyltransferase reviewed xpt - - - 4500 -
Q5HGM3 BXGT015409 Guanylate kinase reviewed gmk - - - - -
Q9NRG1 BXGT021186 Phosphoribosyltransferase domain-containing protein 1 reviewed PRTFDC1 Enzyme - - - -
Q04178 BXGT012753 Hypoxanthine-guanine phosphoribosyltransferase reviewed HPT1 - - - - -
O35820 BXGT004538 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 reviewed Dnph1 - - - - -
Q9Y233 BXGT022210 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A reviewed PDE10A - - - - -
P12823 BXGT007851 Genome polyprotein reviewed - - - - -
Q9V119 BXGT021854 Exosome complex component Rrp41 reviewed rrp41 - - - - -
A5K709 BXGT001339 Guanylate kinase, putative unreviewed PVX_099895 - - - - -
O35014 BXGT004512 Uncharacterized EAL-domain containing protein YkuI reviewed ykuI - - - - -
P49902 BXGT010758 Cytosolic purine 5'-nucleotidase reviewed NT5C2 Enzyme - - - -
Q5SLS3 BXGT015820 Hypoxanthine phosphoribosyltransferase unreviewed TTHA0220 - - - - -
Q763K9 BXGT016850 16S rRNA (guanine(1405)-N(7))-methyltransferase unreviewed rmtB - - - - -
O76083 BXGT005176 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A reviewed PDE9A - - - - -
A7ZS61 BXGT001653 Polyribonucleotide nucleotidyltransferase reviewed pnp - - - - -
B9ZW32 BXGT002363 Hypoxanthine phosphoribosyltransferase unreviewed hpt - - - - -
B7SY86 BXGT002265 Mannosyl-3-phosphoglycerate synthase unreviewed - - - - -
Q88EQ6 BXGT017711 Flagellar brake protein YcgR reviewed ycgR - - - - -
Q9KNC3 BXGT020955 Cyclic di-GMP binding protein VCA0042 reviewed VC_A0042 - - - - -
Q2GLF7 BXGT014083 Guanylate kinase reviewed gmk - - - - -
Q9UKV8 BXGT021752 Protein argonaute-2 reviewed AGO2 - - - 3300000 -
Q2YQ74 BXGT014278 Beta-lactamase-like unreviewed BAB1_1016 - - - - -
P0ACE7 BXGT007263 Purine nucleoside phosphoramidase reviewed hinT - - - - -
C4LYI2 BXGT002478 Histidine triad nucleotide-binding protein reviewed EHI_093910 - - - - -
Q980A5 BXGT019870 Translation initiation factor 2 subunit gamma reviewed eif2g - - - - -
Q859P9 BXGT017572 Virion DNA-directed RNA polymerase reviewed 50 - - - - -
P80912 BXGT011926 Histidine triad nucleotide-binding protein 1 reviewed HINT1 - - - - -
B1WBP0 BXGT001924 Metallophosphoesterase MPPED2 reviewed Mpped2 - - 67 - -
B1WBP0 BXGT001924 Metallophosphoesterase MPPED2 reviewed Mpped2 - - 3800 - -
Q83EL7 BXGT017506 Guanylate kinase reviewed gmk - - - - -
Q64PD9 BXGT016136 Putative exopolyphosphatase-related protein unreviewed BF3900 - - - - -
P78356 BXGT011837 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta reviewed PIP4K2B Kinase - - - -
D0CB74 BXGT002670 Riboflavin biosynthesis protein RibD unreviewed ribD - - - - -
Q8J307 BXGT018379 MJ0495-like protein unreviewed selB - - - - -
O59245 BXGT004842 tRNA-splicing ligase RtcB reviewed rtcB - - - - -
Q182D4 BXGT013709 Putative histidine triad (HIT) protein unreviewed CD630_24470 - - - - -
O06961 BXGT003995 Propionate kinase reviewed tdcD - - - - -
O04379 BXGT003964 Protein argonaute 1 reviewed AGO1 - - - 6130000 -
Q89VT8 BXGT017748 Amino acid--[acyl-carrier-protein] ligase 1 reviewed bll0957 - - - - -
P0C794 BXGT007446 Matrix protein reviewed M - - - - -
Q8C6L5 BXGT017928 Cyclic GMP-AMP synthase reviewed Cgas - - - - -
P33469 BXGT009726 Nucleoprotein reviewed N - - - - -
C0QQ26 BXGT002399 Metal dependent phosphohydrolase unreviewed PERMA_0986 - - - - -
O57978 BXGT004774 Phosphoribosylaminoimidazole-succinocarboxamide synthase reviewed purC - - - - -
Q5ZZB6 BXGT015967 Cytosolic IMP-GMP specific 5'-nucleotidase unreviewed lpg0095 - - - - -
P22434 BXGT008765 3',5'-cyclic-nucleotide phosphodiesterase 1 reviewed PDE1 - - - - -
C4M1P9 BXGT002480 RNA lariat debranching enzyme, putative unreviewed EHI_062730 - - - - -
D9J2T9 BXGT003028 Ribosome inactivating protein unreviewed RIP - - - - -
P9WHQ9 BXGT012304 Hypoxanthine-guanine phosphoribosyltransferase reviewed hpt - - - - -
O74859 BXGT005090 Aprataxin-like protein reviewed hnt3 - - - - -
Q756Z6 BXGT016835 Inosine-5'-monophosphate dehydrogenase unreviewed AGOS_AER117W - 600000 - - -
Q756Z6 BXGT016835 Inosine-5'-monophosphate dehydrogenase unreviewed AGOS_AER117W - - - - -
Q97W22 BXGT019842 Purine phosphoribosyltransferase (GpT-2) unreviewed gpT-2 - - - - -
Q07010 BXGT012911 Hypoxanthine-guanine phosphoribosyltransferase reviewed HGPRT - - - - -
Q99QC1 BXGT020002 Beta-lactamase unreviewed blaCMY-10 - 20800 - - -
P49773 BXGT010741 Histidine triad nucleotide-binding protein 1 reviewed HINT1 Enzyme - - - -
Q97ZE7 BXGT019865 Signal recognition particle 54 kDa protein reviewed srp54 - - - - -
Q9HXH7 BXGT020648 Uncharacterized protein unreviewed PA3825 - - - - -
Q9X1T1 BXGT022111 Uncharacterized protein unreviewed TM_1595 - - - - -
P14583 BXGT008023 Putative mRNA-capping enzyme P5 reviewed - - - - -
Q8ZC05 BXGT019172 Xanthine phosphoribosyltransferase reviewed gpt - - - - -
Q9I4L4 BXGT020736 YfiR unreviewed yfiR - - - - -
O57947 BXGT004770 Ribose 1,5-bisphosphate isomerase reviewed PH0208 - - - - -
P06802 BXGT006508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 reviewed Enpp1 - - - - -
P07741 BXGT006666 Adenine phosphoribosyltransferase reviewed APRT - 170000 - - -
P12268 BXGT007783 Inosine-5'-monophosphate dehydrogenase 2 reviewed IMPDH2 Enzyme - - - -
Q8LPL7 BXGT024420 Adenosine/AMP deaminase family protein reviewed MAPDA - - - - -
Q57ZS7 BXGT015167 Inosine-5'-monophosphate dehydrogenase unreviewed Tb927.5.2080 - - - - -
J9VQ84 BXGT003761 Guanylate kinase unreviewed CNAG_01364 - - - - -
Q38CA1 BXGT014363 Hypoxanthine-guanine phosphoribosyltransferase, putative unreviewed Tb10.70.6660 - 2730 - - -
Q1WK45 BXGT025040 Protein VP3 [Includes: 2',5'-phosphodiesterase unreviewed VP3 - - - - -
P40107 BXGT010157 GDP-mannose transporter 1 reviewed VRG4 - - - - -
P50098 BXGT025435 Inosine-5'-monophosphate dehydrogenase reviewed - - - - -
B2FT06 BXGT025895 Guanylate kinase unreviewed gmk - - - - -
Q8C6L5 BXGT017928 Cyclic GMP-AMP synthase reviewed Cgas - - - - -
Binding DB 50010318
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP 1500000 - - -
reviewed BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase reviewed Enzyme HPRT1 5800 - - -
CHEMBL CHEMBL283807
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16774 BXGT013668 Guanylate kinase reviewed Kinase GUK1 Km '=' 18000 nM
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase reviewed Enzyme HPRT1 Ki '=' 5800 nM
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP Activity '=' 4 %
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP Inhibition '=' 16 %
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP Ki '=' 1500000 nM
Q9Y231 BXGT022209 Alpha-(1,3)-fucosyltransferase 9 reviewed Enzyme FUT9 Inhibition - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04132 Mallotus philippensis Mallotus philippensis Medicinal Plant
BXGF04698 Isodon rubescens Isodon rubescens Others
BXGF04779 Coleus frederici Coleus frederici Others
BXGF04822 Libanotis intermedia Libanotis intermedia Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease