adisease

Showing entry for Brain Diseases

General Disease Information
BXGD Id	BXGD000369
Disease Name	Brain Diseases
Disease CUI Id	C0006111
MeSH Codes	C10
Disease Class Name	Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00459	BXGT003924	Phosphatidylinositol 3-kinase regulatory subunit beta	5296	reviewed	Enzyme modulator
O14594	BXGT004073	Neurocan core protein	1463	reviewed	Extracellular structure
O14672	BXGT004081	Disintegrin and metalloproteinase domain-containing protein 10	102	reviewed
O14684	BXGT004082	Prostaglandin E synthase	9536	reviewed
O15394	BXGT004163	Neural cell adhesion molecule 2	4685	reviewed
O15409	BXGT004166	Forkhead box protein P2	93986	reviewed
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43612	BXGT004605	Orexin	3060	reviewed
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60706	BXGT004896	ATP-binding cassette sub-family C member 9	10060	reviewed	Transporter
O75173	BXGT005105	A disintegrin and metalloproteinase with thrombospondin motifs 4	9507	reviewed	Enzyme
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
O75880	BXGT005158	Protein SCO1 homolog, mitochondrial	6341	reviewed	Enzyme
O76083	BXGT005176	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	5152	reviewed
O94759	BXGT005327	Transient receptor potential cation channel subfamily M member 2	7226	reviewed	Ion channel
O94925	BXGT005342	Glutaminase kidney isoform, mitochondrial	2744	reviewed	Enzyme
O95069	BXGT005348	Potassium channel subfamily K member 2	3776	reviewed	Ion channel
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00480	BXGT005551	Ornithine carbamoyltransferase, mitochondrial	5009	reviewed
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01275	BXGT005747	Glucagon	2641	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02462	BXGT005881	Collagen alpha-1(IV) chain	1282	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04083	BXGT006147	Annexin A1	301	reviewed
P04156	BXGT006156	Major prion protein	5621	reviewed
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05154	BXGT006327	Plasma serine protease inhibitor	5104	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07332	BXGT006601	Tyrosine-protein kinase Fes/Fps	2242	reviewed	Kinase
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P11169	BXGT007664	Solute carrier family 2, facilitated glucose transporter member 3	6515	reviewed	Transporter
P11509	BXGT007716	Cytochrome P450 2A6	1548	reviewed
P11926	BXGT007760	Ornithine decarboxylase	4953	reviewed	Enzyme
P14324	BXGT008005	Farnesyl pyrophosphate synthase	2224	reviewed	Enzyme
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14618	BXGT008027	Pyruvate kinase PKM	5315	reviewed	Kinase
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P15309	BXGT008105	Prostatic acid phosphatase	55	reviewed	Enzyme
P15328	BXGT008108	Folate receptor alpha	2348	reviewed
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P17643	BXGT008323	5,6-dihydroxyindole-2-carboxylic acid oxidase	7306	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P19652	BXGT008506	Alpha-1-acid glycoprotein 2	5005	reviewed
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22304	BXGT008752	Iduronate 2-sulfatase	3423	reviewed
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23946	BXGT008932	Chymase	1215	reviewed	Enzyme
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P30536	BXGT009435	Translocator protein	706	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P30989	BXGT009492	Neurotensin receptor type 1	4923	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P33981	BXGT009744	Dual specificity protein kinase TTK	7272	reviewed	Kinase
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42858	BXGT010341	Huntingtin	3064	reviewed
P43003	BXGT010347	Excitatory amino acid transporter 1	6507	reviewed	Transporter
P43004	BXGT010348	Excitatory amino acid transporter 2	6506	reviewed	Transporter
P43005	BXGT010349	Excitatory amino acid transporter 3	6505	reviewed	Transporter
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43354	BXGT010381	Nuclear receptor subfamily 4 group A member 2	4929	reviewed	Nuclear receptor
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48147	BXGT010620	Prolyl endopeptidase	5550	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49591	BXGT010715	Serine--tRNA ligase, cytoplasmic	6301	reviewed	Enzyme
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P53779	BXGT011014	Mitogen-activated protein kinase 10	5602	reviewed	Kinase
P53985	BXGT011022	Monocarboxylate transporter 1	6566	reviewed	Transporter
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54760	BXGT011075	Ephrin type-B receptor 4	2050	reviewed	Kinase
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P58400	BXGT011235	Neurexin-1-beta	9378	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P98160	BXGT012228	Basement membrane-specific heparan sulfate proteoglycan core protein	3339	reviewed	Enzyme modulator
Q00266	BXGT012515	S-adenosylmethionine synthase isoform type-1	4143	reviewed	Enzyme
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q00613	BXGT012540	Heat shock factor protein 1	3297	reviewed	Transcription factor
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	8140	reviewed	Transporter
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q07157	BXGT012920	Tight junction protein ZO-1	7082	reviewed	Cell-cell junction
Q08499	BXGT012988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	5144	reviewed
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q13148	BXGT013318	TAR DNA-binding protein 43	23435	reviewed
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13304	BXGT013337	Uracil nucleotide/cysteinyl leukotriene receptor	2840	reviewed	G-protein coupled receptor
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13509	BXGT013366	Tubulin beta-3 chain	10381	reviewed	Cellular structure
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q13621	BXGT013383	Solute carrier family 12 member 1	6557	reviewed	Transporter
Q13639	BXGT013389	5-hydroxytryptamine receptor 4	3360	reviewed	G-protein coupled receptor
Q13936	BXGT013404	Voltage-dependent L-type calcium channel subunit alpha-1C	775	reviewed	Ion channel
Q14232	BXGT013457	Translation initiation factor eIF-2B subunit alpha	1967	reviewed
Q14416	BXGT013468	Metabotropic glutamate receptor 2	2912	reviewed	G-protein coupled receptor
Q15078	BXGT013534	Cyclin-dependent kinase 5 activator 1	8851	reviewed	Enzyme modulator
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15303	BXGT013557	Receptor tyrosine-protein kinase erbB-4	2066	reviewed	Kinase
Q15485	BXGT013574	Ficolin-2	2220	reviewed	Signaling
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16555	BXGT013638	Dihydropyrimidinase-related protein 2	1808	reviewed	Enzyme
Q2M385	BXGT014131	Macrophage-expressed gene 1 protein	219972	reviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q7L576	BXGT016995	Cytoplasmic FMR1-interacting protein 1	23191	reviewed	Enzyme modulator
Q7RTX0	BXGT017088	Taste receptor type 1 member 3	83756	reviewed	G-protein coupled receptor
Q8IVS2	BXGT018349	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	27349	reviewed
Q8N0W4	BXGT018492	Neuroligin-4, X-linked	57502	reviewed
Q8TCC7	BXGT018794	Solute carrier family 22 member 8	9376	reviewed	Transporter
Q8TDS5	BXGT018813	Oxoeicosanoid receptor 1	165140	reviewed	G-protein coupled receptor
Q8TDV0	BXGT018815	Probable G-protein coupled receptor 151	134391	reviewed	G-protein coupled receptor
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q96C19	BXGT019630	EF-hand domain-containing protein D2	79180	reviewed	Calcium-binding protein
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q99527	BXGT019930	G-protein coupled estrogen receptor 1	2852	reviewed	G-protein coupled receptor
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99574	BXGT019936	Neuroserpin	5274	reviewed	Enzyme modulator
Q9BUL9	BXGT020136	Ribonuclease P protein subunit p25	54913	reviewed	Enzyme
Q9BZR6	BXGT020202	Reticulon-4 receptor	65078	reviewed
Q9H3M7	BXGT020462	Thioredoxin-interacting protein	10628	reviewed
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HBH1	BXGT020519	Peptide deformylase, mitochondrial	64146	reviewed
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NR12	BXGT021174	PDZ and LIM domain protein 7	9260	reviewed	Cellular structure
Q9NTG7	BXGT021211	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	23410	reviewed	Epigenetic regulator
Q9NY91	BXGT021253	Solute carrier family 5 member 4	6527	reviewed	Transporter
Q9ULC4	BXGT021757	Malignant T-cell-amplified sequence 1	28985	reviewed	Receptor
Q9ULV1	BXGT021764	Frizzled-4	8322	reviewed	G-protein coupled receptor
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y698	BXGT022323	Voltage-dependent calcium channel gamma-2 subunit	10369	reviewed	Ion channel
Q9Y6A2	BXGT022324	Cholesterol 24-hydroxylase	10858	reviewed	Enzyme
P19235	BXGT022895	Erythropoietin receptor	2057	reviewed	Receptor
Q9UBP0	BXGT023601	Spastin	6683	reviewed	Cellular structure
O43583	BXGT024866	Density-regulated protein	8562	reviewed	Enzyme
Q9BYC5	BXGT025656	Alpha-(1,6)-fucosyltransferase	2530	reviewed
Q8TAB3	BXGT025819	Protocadherin-19	57526	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}