Showing entry for Proto-oncogene tyrosine-protein kinase LCK


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006428
Protein NameProto-oncogene tyrosine-protein kinase LCK
Uniport IdP06240
GeneLck
Gene Id16818
DomainPkinase_Tyr; SH2; SH3_1
Pfam PF07714   PF00017   PF00018  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0050853 B cell receptor signaling pathway
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0006882 cellular zinc ion homeostasis
Biological Process GO:0045087 innate immune response
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0045588 positive regulation of gamma-delta T cell differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0034116 positive regulation of heterotypic cell-cell adhesion
Biological Process GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Biological Process GO:1903039 positive regulation of leukocyte cell-cell adhesion
Biological Process GO:0050870 positive regulation of T cell activation
Biological Process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0070474 positive regulation of uterine smooth muscle contraction
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0045589 regulation of regulatory T cell differentiation
Biological Process GO:0050856 regulation of T cell receptor signaling pathway
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0042493 response to drug
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0010038 response to metal ion
Biological Process GO:0030217 T cell differentiation
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0003823 antigen binding
molecular function GO:0051117 ATPase binding
molecular function GO:0005524 ATP binding
molecular function GO:0042609 CD4 receptor binding
molecular function GO:0042610 CD8 receptor binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0043548 phosphatidylinositol 3-kinase binding
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:1990405 protein antigen binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0004722 protein serine/threonine phosphatase activity
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0042169 SH2 domain binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0042608 T cell receptor binding
cellular component GO:0005911 cell-cell junction
cellular component GO:0005829 cytosol
cellular component GO:0030139 endocytic vesicle
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0001772 immunological synapse
cellular component GO:0045121 membrane raft
cellular component GO:0000242 pericentriolar material
cellular component GO:0005886 plasma membrane
cellular component GO:0099091 postsynaptic specialization, intracellular component
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0007014 Harman 182.22
BXGC0034256 Rottlerin 516.18
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein