Showing entry for Sl-0101


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0051873
Compound NameSl-0101
Structure
FormulaC25H24O12
InchiKeySXOZSDJHGMAEGZ-IGKKHSBFSA-N
SMILESCC(=O)O[C@H]1[C@H](C)O[C@H]([C@@H]([C@@H]1OC(=O)C)O)Oc1c(oc2c(c1=O)c(O)cc(c2)O)c1ccc(cc1)O
InchiInChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1
IUPAC[(2S,3S,4S,5R,6S)-4-acetyloxy-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-5-hydroxy-2-methyloxan-3-yl] acetate
Molecular Weight516.13
Pubchem Id10459196
Chembl IdCHEMBL240954
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB SL0
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P18654 BXGT008418 Ribosomal protein S6 kinase alpha-3 reviewed Rps6ka3 - - - 2900 -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL240954
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O75582 BXGT005137 Ribosomal protein S6 kinase alpha-5 reviewed Kinase RPS6KA5 Activity '=' 101 %
P49137 BXGT010680 MAP kinase-activated protein kinase 2 reviewed Kinase MAPKAPK2 Activity '=' 95 %
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 90 %
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase reviewed Kinase AKT2 Activity '=' 99 %
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Activity '=' 88 %
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 Activity '=' 89 %
Q9NQU5 BXGT021169 Serine/threonine-protein kinase PAK 6 reviewed - PAK6 Activity '=' 127 %
O75116 BXGT005100 Rho-associated protein kinase 2 reviewed Kinase ROCK2 Activity '=' 109 %
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 Activity '=' 85 %
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 reviewed Kinase PIM2 Activity '=' 95 %
Q96RR4 BXGT019734 Calcium/calmodulin-dependent protein kinase kinase 2 reviewed Kinase CAMKK2 Activity '=' 108 %
Q8IW41 BXGT018352 MAP kinase-activated protein kinase 5 reviewed Kinase MAPKAPK5 Activity '=' 82 %
Q8N5S9 BXGT018520 Calcium/calmodulin-dependent protein kinase kinase 1 reviewed Kinase CAMKK1 Activity '=' 116 %
Q16644 BXGT013647 MAP kinase-activated protein kinase 3 reviewed Kinase MAPKAPK3 Activity '=' 112 %
P51955 BXGT010908 Serine/threonine-protein kinase Nek2 reviewed Kinase NEK2 Activity '=' 101 %
P00523 BXGT005572 Proto-oncogene tyrosine-protein kinase Src reviewed - SRC Activity '=' 105 %
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle reviewed Kinase MYLK Activity '=' 109 %
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 reviewed Kinase PDPK1 Activity '=' 103 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Activity '=' 23 %
P78396 BXGT011842 Cyclin-A1 reviewed Enzyme modulator CCNA1 Activity '=' 106 %
P20248 BXGT008554 Cyclin-A2 reviewed Enzyme modulator CCNA2 Activity '=' 106 %
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Activity '=' 106 %
P45984 BXGT010495 Mitogen-activated protein kinase 9 reviewed Kinase MAPK9 Activity '=' 94 %
P41240 BXGT010242 Tyrosine-protein kinase CSK reviewed Kinase CSK Activity '=' 105 %
Q8IWQ3 BXGT018355 Serine/threonine-protein kinase BRSK2 reviewed Kinase BRSK2 Activity '=' 80 %
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Activity '=' 98 %
Q9H2X6 BXGT020458 Homeodomain-interacting protein kinase 2 reviewed Kinase HIPK2 Activity '=' 72 %
Q8TD08 BXGT018803 Mitogen-activated protein kinase 15 reviewed Kinase MAPK15 Activity '=' 89 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Activity '=' 30 %
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 reviewed Kinase SGK1 Activity '=' 110 %
Q9H422 BXGT020469 Homeodomain-interacting protein kinase 3 reviewed Kinase HIPK3 Activity '=' 110 %
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Activity '=' 95 %
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Activity '=' 98 %
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Activity '=' 112 %
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB Activity '=' 100 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 IC50 '=' 990 nM
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 reviewed Kinase MKNK1 Activity '=' 82 %
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 Activity '=' 89 %
Q9HBH9 BXGT020521 MAP kinase-interacting serine/threonine-protein kinase 2 reviewed Kinase MKNK2 Activity '=' 97 %
P27448 BXGT009183 MAP/microtubule affinity-regulating kinase 3 reviewed Kinase MARK3 Activity '=' 113 %
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase reviewed Kinase MELK Activity '=' 102 %
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Activity '=' 101 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Activity '=' 101 %
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Activity '=' 101 %
Q9HC98 BXGT020528 Serine/threonine-protein kinase Nek6 reviewed Kinase NEK6 Activity '=' 109 %
O00418 BXGT003918 Eukaryotic elongation factor 2 kinase reviewed Kinase EEF2K Activity '=' 86 %
Q96GD4 BXGT019667 Aurora kinase B reviewed Kinase AURKB Activity '=' 45 %
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Activity '=' 98 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 IC50 '=' 89 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Activity '=' 80 %
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha reviewed Kinase PRKACA Activity '=' 92 %
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Activity '=' 103 %
Q16513 BXGT013632 Serine/threonine-protein kinase N2 reviewed Kinase PKN2 Activity '=' 107 %
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 reviewed Kinase CHEK2 Activity '=' 99 %
Q96SB4 BXGT019740 SRSF protein kinase 1 reviewed Kinase SRPK1 Activity '=' 96 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Inhibition - - -
P06240 BXGT006428 Proto-oncogene tyrosine-protein kinase LCK reviewed - Lck Activity '=' 88 %
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Activity '=' 89 %
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Activity '=' 71 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Activity '=' 94 %
Q8TDX7 BXGT018817 Serine/threonine-protein kinase Nek7 reviewed Kinase NEK7 Activity '=' 105 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '=' 20600 nM
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Activity '=' 88 %
Q86V86 BXGT017617 Serine/threonine-protein kinase pim-3 reviewed - PIM3 Activity '=' 49 %
P53779 BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 Activity '=' 98 %
O96013 BXGT005414 Serine/threonine-protein kinase PAK 4 reviewed Kinase PAK4 Activity '=' 95 %
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 reviewed Kinase RPS6KB1 Activity '=' 103 %
Q9UQB9 BXGT021810 Aurora kinase C reviewed Kinase AURKC Activity '=' 77 %
Q14012 BXGT013437 Calcium/calmodulin-dependent protein kinase type 1 reviewed Kinase CAMK1 Activity '=' 105 %
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D Activity '=' 88 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Activity '=' 87 %
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 82 %
Q13188 BXGT013324 Serine/threonine-protein kinase 3 reviewed Kinase STK3 Activity '=' 99 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 50500 nM
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 IC50 '=' 583 nM
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 IC50 '=' 370 nM
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Inhibition - - -
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ Activity '=' 82 %
Q9P286 BXGT021299 Serine/threonine-protein kinase PAK 5 reviewed Kinase PAK5 Activity '=' 86 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Activity - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01382 Zingiber aromaticum Zingiber aromaticum Medicinal Plant
BXGF05071 Zingiber spectabile Zingiber spectabile Human Edible Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease