Showing entry for Rottlerin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0034256
Compound NameRottlerin
Structure
FormulaC30H28O8
InchiKeyDEZFNHCVIZBHBI-ZHACJKMWSA-N
SMILESO=C(c1c(O)c(Cc2c(O)c(C)c(c(c2O)C(=O)C)O)c(c2c1OC(C)(C)C=C2)O)/C=C/c1ccccc1
InchiInChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
IUPAC(E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
Molecular Weight516.18
Pubchem Id5281847
Chembl IdCHEMBL34241
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL34241
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 12589 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 19952 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 12589 nM
P49137 BXGT010680 MAP kinase-activated protein kinase 2 reviewed Kinase MAPKAPK2 Inhibition '=' 5 %
Q14012 BXGT013437 Calcium/calmodulin-dependent protein kinase type 1 reviewed Kinase CAMK1 Activity '=' 86 %
P06240 BXGT006428 Proto-oncogene tyrosine-protein kinase LCK reviewed - Lck Activity '=' 81 %
P00811 BXGT005666 Beta-lactamase reviewed - ampC Change in IC50 '>' 50 fold
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 17782 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Activity '=' 88 %
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Activity '=' 97 %
Q9H2X6 BXGT020458 Homeodomain-interacting protein kinase 2 reviewed Kinase HIPK2 Activity '=' 77 %
P05453 BXGT006363 Eukaryotic peptide chain release factor GTP-binding subunit reviewed - SUP35 Inhibition - - -
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Inhibition '=' 130 %
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ Activity '=' 104 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q8IW41 BXGT018352 MAP kinase-activated protein kinase 5 reviewed Kinase MAPKAPK5 IC50 '=' 1900 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 2 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
Q64725 BXGT016130 Tyrosine-protein kinase SYK reviewed - Syk Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 7079 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 3548 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 14125 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 12589 nM
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Inhibition '=' 25 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Inhibition '=' 25 %
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Inhibition '=' 25 %
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Inhibition '=' 25 %
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 11220 nM
Q16644 BXGT013647 MAP kinase-activated protein kinase 3 reviewed Kinase MAPKAPK3 Activity '=' 56 %
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Activity '=' 93 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Activity '=' 93 %
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Activity '=' 93 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 44668 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 11220 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
Q8TDX7 BXGT018817 Serine/threonine-protein kinase Nek7 reviewed Kinase NEK7 Activity '=' 110 %
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Activity '=' 24 %
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 reviewed Kinase RPS6KB1 Activity '=' 69 %
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Activity '=' 92 %
P45984 BXGT010495 Mitogen-activated protein kinase 9 reviewed Kinase MAPK9 Activity '=' 107 %
Q8N5S9 BXGT018520 Calcium/calmodulin-dependent protein kinase kinase 1 reviewed Kinase CAMKK1 Activity '=' 55 %
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 reviewed Kinase PDPK1 Activity '=' 79 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 2511 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 2511 nM
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Inhibition '=' 13 %
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 reviewed Kinase RPS6KB1 Inhibition '=' 98 %
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition '=' 36 %
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Inhibition '=' 127 %
P41240 BXGT010242 Tyrosine-protein kinase CSK reviewed Kinase CSK Activity '=' 87 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 36 %
P53779 BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 Activity '=' 80 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 73 %
Q9H422 BXGT020469 Homeodomain-interacting protein kinase 3 reviewed Kinase HIPK3 Activity '=' 86 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Activity '=' 82 %
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 39810 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 2119 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC IC50 '=' 1800 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC IC50 '=' 21000 nM
P49137 BXGT010680 MAP kinase-activated protein kinase 2 reviewed Kinase MAPKAPK2 IC50 '=' 5400 nM
Q62868 BXGT016047 Rho-associated protein kinase 2 reviewed - Rock2 Inhibition '=' 88 %
Q8IW41 BXGT018352 MAP kinase-activated protein kinase 5 reviewed Kinase MAPKAPK5 Inhibition '=' 6 %
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 35481 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 28183 nM
Q9HBH9 BXGT020521 MAP kinase-interacting serine/threonine-protein kinase 2 reviewed Kinase MKNK2 Activity '=' 90 %
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle reviewed Kinase MYLK Activity '=' 49 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 25118 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 31622 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 2119 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 11220 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Inhibition '=' 70 %
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 15848 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Activity '=' 82 %
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 Activity '=' 87 %
Q8IWQ3 BXGT018355 Serine/threonine-protein kinase BRSK2 reviewed Kinase BRSK2 Activity '=' 92 %
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 7943 nM
P51955 BXGT010908 Serine/threonine-protein kinase Nek2 reviewed Kinase NEK2 Activity '=' 101 %
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Activity '=' 72 %
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase reviewed Kinase MELK Activity '=' 70 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 17782 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 37933 nM
O75116 BXGT005100 Rho-associated protein kinase 2 reviewed Kinase ROCK2 Activity '=' 90 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 34 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 40 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 22 %
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 25118 nM
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity - - -
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 2 -
Q9HC98 BXGT020528 Serine/threonine-protein kinase Nek6 reviewed Kinase NEK6 Activity '=' 92 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 3 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 11 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 2 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 3 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 35 %
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase reviewed Kinase AKT2 Activity '=' 92 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Activity '=' 67 %
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 33807 nM
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Activity '=' 58 %
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 Activity '=' 39 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 20 %
P27448 BXGT009183 MAP/microtubule affinity-regulating kinase 3 reviewed Kinase MARK3 Activity '=' 79 %
O75582 BXGT005137 Ribosomal protein S6 kinase alpha-5 reviewed Kinase RPS6KA5 Inhibition '=' 38 %
P29597 BXGT009367 Non-receptor tyrosine-protein kinase TYK2 reviewed Kinase TYK2 Inhibition '>' 65 %
O60674 BXGT004892 Tyrosine-protein kinase JAK2 reviewed Kinase JAK2 Inhibition '>' 65 %
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Inhibition '>' 65 %
P52333 BXGT010928 Tyrosine-protein kinase JAK3 reviewed Kinase JAK3 Inhibition '>' 65 %
Q86V86 BXGT017617 Serine/threonine-protein kinase pim-3 reviewed - PIM3 Activity '=' 14 %
Q8IW41 BXGT018352 MAP kinase-activated protein kinase 5 reviewed Kinase MAPKAPK5 Activity '=' 36 %
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Inhibition '=' 139 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 2 -
P05453 BXGT006363 Eukaryotic peptide chain release factor GTP-binding subunit reviewed - SUP35 Inhibition '=' 99 %
O00418 BXGT003918 Eukaryotic elongation factor 2 kinase reviewed Kinase EEF2K Activity '=' 84 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 39810 nM
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 47754 nM
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D Activity '=' 87 %
P05453 BXGT006363 Eukaryotic peptide chain release factor GTP-binding subunit reviewed - SUP35 Inhibition '=' 40 %
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Inhibition '=' 27 %
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 8912 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 44668 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 28183 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 26679 nM
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 reviewed Kinase SGK1 Activity '=' 76 %
O96013 BXGT005414 Serine/threonine-protein kinase PAK 4 reviewed Kinase PAK4 Activity '=' 37 %
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD Inhibition '=' 101 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 3981 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 17612 nM
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Activity '=' 88 %
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 5011 nM
P17538 BXGT008314 Chymotrypsinogen B reviewed Enzyme CTRB1 IC50 '=' 25000 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 39810 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 56234 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 79432 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 19952 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 19952 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 11220 nM
P61586 BXGT011375 Transforming protein RhoA reviewed Enzyme modulator RHOA Inhibition - - -
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Inhibition '=' 103 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Inhibition '=' 103 %
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Inhibition '=' 103 %
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Activity '=' 86 %
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Inhibition '=' 107 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 31 %
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 35481 nM
Q13188 BXGT013324 Serine/threonine-protein kinase 3 reviewed Kinase STK3 Activity '=' 63 %
P00811 BXGT005666 Beta-lactamase reviewed - ampC IC50 - - -
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 22387 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 1000 nM
Q9UQB9 BXGT021810 Aurora kinase C reviewed Kinase AURKC Activity '=' 54 %
P78396 BXGT011842 Cyclin-A1 reviewed Enzyme modulator CCNA1 Activity '=' 93 %
P20248 BXGT008554 Cyclin-A2 reviewed Enzyme modulator CCNA2 Activity '=' 93 %
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Activity '=' 93 %
P00811 BXGT005666 Beta-lactamase reviewed - ampC Inhibition '=' 5 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 44 %
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 reviewed Kinase MKNK1 Activity '=' 85 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 4 %
P00811 BXGT005666 Beta-lactamase reviewed - ampC Inhibition '=' 90 %
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 Inhibition '>' 60 %
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 95 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 14125 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC IC50 '=' 1200 nM
Q16513 BXGT013632 Serine/threonine-protein kinase N2 reviewed Kinase PKN2 Activity '=' 80 %
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 19952 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 25118 nM
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 Activity '=' 71 %
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 reviewed Kinase CHEK2 Activity '=' 12 %
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD IC50 '=' 3000 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Change in IC50 '=' 6 fold
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 1 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC Activity '=' 21 %
P10584 BXGT007580 Malate dehydrogenase reviewed - mdh IC50 '=' 700 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 41839 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC IC50 '=' 76000 nM
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha reviewed Kinase PRKACA Activity '=' 69 %
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 79432 nM
Q96RR4 BXGT019734 Calcium/calmodulin-dependent protein kinase kinase 2 reviewed Kinase CAMKK2 Activity '=' 50 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Activity '=' 110 %
P49137 BXGT010680 MAP kinase-activated protein kinase 2 reviewed Kinase MAPKAPK2 Activity '=' 43 %
Q8TD08 BXGT018803 Mitogen-activated protein kinase 15 reviewed Kinase MAPK15 Activity '=' 78 %
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD Inhibition - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 29081 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 10000 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 10000 nM
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Activity '=' 109 %
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 25118 nM
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 reviewed Kinase PIM2 Activity '=' 98 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 17782 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 16360 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 56234 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 10621 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 8912 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 37685 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 50118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 13335 nM
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Inhibition '=' 146 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 15 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 14125 nM
Q8TAF3 BXGT018786 WD repeat-containing protein 48 reviewed - WDR48 IC50 '=' 8000 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 IC50 '=' 8000 nM
P13267 BXGT007895 DNA polymerase III PolC-type reviewed - polC Potency - 18887 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 19761 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 25118 nM
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB Activity '=' 65 %
P00523 BXGT005572 Proto-oncogene tyrosine-protein kinase Src reviewed - SRC Activity '=' 80 %
Q96SB4 BXGT019740 SRSF protein kinase 1 reviewed Kinase SRPK1 Activity '=' 7 %
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 reviewed Kinase SGK1 Inhibition '=' 81 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 8912 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 5011 nM
O75582 BXGT005137 Ribosomal protein S6 kinase alpha-5 reviewed Kinase RPS6KA5 Activity '=' 82 %
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Inhibition '=' 49 %
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 2 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 4 -
Q83TT7 BXGT017514 AmpC unreviewed - ampC FC '=' 3 -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Inhibition '=' 95 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Inhibition '=' 111 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Activity '=' 71 %
Q96GD4 BXGT019667 Aurora kinase B reviewed Kinase AURKB Activity '=' 38 %
Q9P286 BXGT021299 Serine/threonine-protein kinase PAK 5 reviewed Kinase PAK5 Activity '=' 75 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 2592 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 15848 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 18887 nM
P29597 BXGT009367 Non-receptor tyrosine-protein kinase TYK2 reviewed Kinase TYK2 Inhibition '=' 25 %
O60674 BXGT004892 Tyrosine-protein kinase JAK2 reviewed Kinase JAK2 Inhibition '=' 25 %
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Inhibition '=' 25 %
P52333 BXGT010928 Tyrosine-protein kinase JAK3 reviewed Kinase JAK3 Inhibition '=' 25 %
Q9NQU5 BXGT021169 Serine/threonine-protein kinase PAK 6 reviewed - PAK6 Activity '=' 94 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 28183 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 18887 nM
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Activity '=' 83 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04462 Onoseris lopezii Onoseris lopezii Others
BXGF04718 Miconia myriantha Miconia myriantha Others
BXGF04731 Populus grandidentata Populus grandidentata Medicinal Plant
BXGF04754 Eupatorium hyssopifolium Eupatorium hyssopifolium Medicinal Plant
BXGF04796 Sinoadina racemosa Sinoadina racemosa Medicinal Plant
BXGF04840 Picea breweriana Picea breweriana Medicinal Plant
BXGF04863 Maytenus horrida Maytenus horrida Others
BXGF04867 Baileya multiradiata Baileya multiradiata Medicinal Plant
BXGF04884 Erigeron linifolius Erigeron linifolius Others
BXGF04891 Virola elongata Virola elongata Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease