adisease

Showing entry for Blast Phase

General Disease Information
BXGD Id	BXGD000325
Disease Name	Blast Phase
Disease CUI Id	C0005699
MeSH Codes	C23 C04 C15
Disease Class Name	Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O14727	BXGT004084	Apoptotic protease-activating factor 1	317	reviewed
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15350	BXGT004154	Tumor protein p73	7161	reviewed	Transcription factor
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02724	BXGT005934	Glycophorin-A	2993	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P07237	BXGT006576	Protein disulfide-isomerase	5034	reviewed
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P08758	BXGT006821	Annexin A5	308	reviewed
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P09958	BXGT006950	Furin	5045	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12830	BXGT007852	Cadherin-1	999	reviewed
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P13051	BXGT007877	Uracil-DNA glycosylase	7374	reviewed
P14598	BXGT008024	Neutrophil cytosol factor 1	653361	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15036	BXGT008073	Protein C-ets-2	2114	reviewed	Transcription factor
P15144	BXGT008087	Aminopeptidase N	290	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	5770	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P21439	BXGT008649	Phosphatidylcholine translocator ABCB4	5244	reviewed	Transporter
P22083	BXGT008727	Alpha-(1,3)-fucosyltransferase 4	2526	reviewed	Enzyme
P22681	BXGT008795	E3 ubiquitin-protein ligase CBL	867	reviewed	Enzyme
P23443	BXGT008866	Ribosomal protein S6 kinase beta-1	6198	reviewed	Kinase
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P28072	BXGT009231	Proteasome subunit beta type-6	5694	reviewed
P29218	BXGT009322	Inositol monophosphatase 1	3612	reviewed	Enzyme
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P33527	BXGT009728	Multidrug resistance-associated protein 1	4363	reviewed	Transporter
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P41145	BXGT010225	Kappa-type opioid receptor	4986	reviewed	G-protein coupled receptor
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P42330	BXGT010301	Aldo-keto reductase family 1 member C3	8644	reviewed	Enzyme
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P45984	BXGT010495	Mitogen-activated protein kinase 9	5601	reviewed	Kinase
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50120	BXGT010773	Retinol-binding protein 2	5948	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P54687	BXGT011067	Branched-chain-amino-acid aminotransferase, cytosolic	586	reviewed	Enzyme
P54760	BXGT011075	Ephrin type-B receptor 4	2050	reviewed	Kinase
P55157	BXGT011108	Microsomal triglyceride transfer protein large subunit	4547	reviewed	Transporter
P55265	BXGT011117	Double-stranded RNA-specific adenosine deaminase	103	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P61586	BXGT011375	Transforming protein RhoA	387	reviewed	Enzyme modulator
P61626	BXGT011382	Lysozyme C	4069	reviewed
P61978	BXGT011399	Heterogeneous nuclear ribonucleoprotein K	3190	reviewed	Enzyme
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P78396	BXGT011842	Cyclin-A1	8900	reviewed	Enzyme modulator
Q00534	BXGT012533	Cyclin-dependent kinase 6	1021	reviewed	Kinase
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q01105	BXGT012569	Protein SET	6418	reviewed	Enzyme modulator
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q07075	BXGT012917	Glutamyl aminopeptidase	2028	reviewed	Enzyme
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07817	BXGT012941	Bcl-2-like protein 1	598	reviewed	Signaling
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q14469	BXGT013473	Transcription factor HES-1	3280	reviewed	Transcription factor
Q15022	BXGT013523	Polycomb protein SUZ12	23512	reviewed	Nucleic acid binding
Q15257	BXGT013554	Serine/threonine-protein phosphatase 2A activator	5524	reviewed	Enzyme modulator
Q15366	BXGT013559	Poly(rC)-binding protein 2	5094	reviewed	Enzyme
Q16658	BXGT013651	Fascin	6624	reviewed	Cellular structure
Q53H47	BXGT015014	Histone-lysine N-methyltransferase SETMAR	6419	reviewed	Epigenetic regulator
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q8TCG1	BXGT018797	Protein CIP2A	57650	reviewed
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q9BUB5	BXGT020133	MAP kinase-interacting serine/threonine-protein kinase 1	8569	reviewed	Kinase
Q9NP87	BXGT021146	DNA-directed DNA/RNA polymerase mu	27434	reviewed	Enzyme
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UJU2	BXGT021730	Lymphoid enhancer-binding factor 1	51176	reviewed
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q13029	BXGT022688	PR domain zinc finger protein 2	7799	reviewed
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
P56703	BXGT023722	Proto-oncogene Wnt-3	7473	reviewed	Signaling
P20138	BXGT023857	Myeloid cell surface antigen CD33	945	reviewed	Receptor
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
P21926	BXGT024578	CD9 antigen	928	reviewed
Q96M98	BXGT024941	Parkin coregulated gene protein	135138	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
Q92888	BXGT026130	Rho guanine nucleotide exchange factor 1	9138	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}