Showing entry for Ganglioside GM2 activator


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008353
Protein NameGanglioside GM2 activator
Uniport IdP17900
GeneGM2A
Gene Id2760
DomainE1_DerP2_DerF2
Pfam PF02221  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006689 ganglioside catabolic process
Biological Process GO:0006687 glycosphingolipid metabolic process
Biological Process GO:0007611 learning or memory
Biological Process GO:0019915 lipid storage
Biological Process GO:0006869 lipid transport
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0009313 oligosaccharide catabolic process
Biological Process GO:0051345 positive regulation of hydrolase activity
molecular function GO:0032428 beta-N-acetylgalactosaminidase activity
molecular function GO:0005319 lipid transporter activity
molecular function GO:0016004 phospholipase activator activity
molecular function GO:0030290 sphingolipid activator protein activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0043202 lysosomal lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0034880 BXGD002488 Hyperacusis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036161 BXGD002580 Sandhoff Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039373 BXGD002809 Tay-Sachs Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0042834 BXGD003004 Vital capacity
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0206695 BXGD004246 Carcinoma, Neuroendocrine Neoplasms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0220787 BXGD004345 Endotracheal aspiration
C0233522 BXGD004585 Inappropriate behavior Behavior and Behavior Mechanisms
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0268274 BXGD005877 Gangliosidoses, GM2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268275 BXGD005878 Tay-Sachs Disease, AB Variant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349588 BXGD007933 Short stature
C0422895 BXGD008464 Primitive reflex
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542223 BXGD009274 Loss of speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0575059 BXGD009510 Spastic tetraparesis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700198 BXGD009877 Pulmonary aspiration Respiratory Tract Diseases
C0700345 BXGD009886 Candidiasis, Vulvovaginal Female Urogenital Diseases and Pregnancy Complications; Infections
C0877024 BXGD011330 Schimke immunoosseous dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1442826 BXGD013059 Neonatal necrotizing enterocolitis Digestive System Diseases
C1740801 BXGD013744 Exaggerated startle response
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838319 BXGD014309 Primitive reflexes (palmomental, snout, glabellar) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1838579 BXGD014323 Pseudobulbar signs
C1848920 BXGD014986 GM2-ganglioside accumulation
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859736 BXGD015929 Progressive spastic quadriplegia
C1859778 BXGD015931 Postnatal growth retardation
C1861403 BXGD016045 Variable expressivity
C1963221 BXGD016690 Aspiration, CTCAE
C2216370 BXGD016949 Cherry red spot of the macula
C2712334 BXGD017486 Actual Aspiration
C2827071 BXGD017792 Unintentional Material Aspiration
C2919142 BXGD017867 Short Stature, CTCAE
C3806604 BXGD019520 Infantile axial hypotonia
C4022658 BXGD020945 Punctate periventricular T2 hyperintense foci
C4022855 BXGD021013 Abnormal involuntary eye movements
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4293678 BXGD022511 Glabellar reflex
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002248 Dodecanoic acid 200.32
BXGC0003705 Chloride 35.45
BXGC0004266 2-Propanol 60.1
BXGC0023949 phosphatidic acid 704.54
BXGC0034894 Oleic Acid 282.26
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein