Showing entry for Nucleoside diphosphate kinase B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008762
Protein NameNucleoside diphosphate kinase B
Uniport IdP22392
GeneNME2
Gene Id4831;654364
DomainNDK
Pfam PF00334  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.4 Nucleotide metabolism hsa00240 Pyrimidine metabolism
1. Metabolism 1.4 Nucleotide metabolism hsa00240 Pyrimidine metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007155 cell adhesion
Biological Process GO:0071398 cellular response to fatty acid
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0006241 CTP biosynthetic process
Biological Process GO:0006183 GTP biosynthetic process
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0002762 negative regulation of myeloid leukocyte differentiation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0015949 nucleobase-containing small molecule interconversion
Biological Process GO:0006165 nucleoside diphosphate phosphorylation
Biological Process GO:0009142 nucleoside triphosphate biosynthetic process
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0045682 regulation of epidermis development
Biological Process GO:0060416 response to growth hormone
Biological Process GO:0006228 UTP biosynthetic process
molecular function GO:0005524 ATP binding
molecular function GO:0003677 DNA binding
molecular function GO:0008144 drug binding
molecular function GO:0019899 enzyme binding
molecular function GO:0005504 fatty acid binding
molecular function GO:0019003 GDP binding
molecular function GO:0051880 G-quadruplex DNA binding
molecular function GO:0042802 identical protein binding
molecular function GO:0019215 intermediate filament binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004550 nucleoside diphosphate kinase activity
molecular function GO:0004673 protein histidine kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0003713 transcription coactivator activity
cellular component GO:0071944 cell periphery
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005882 intermediate filament
cellular component GO:0030027 lamellipodium
cellular component GO:0031966 mitochondrial membrane
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0001726 ruffle
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205851 BXGD004132 Germ cell tumor Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0489786 BXGD009018 Height
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0741548 BXGD010036 bladder symptoms
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1334407 BXGD012704 Localized Carcinoma Neoplasms
C1368404 BXGD012899 Hypopharyngeal Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510475 BXGD013171 Diverticulosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4317009 BXGD022717 Diverticular Diseases Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein