adisease

Showing entry for Germ cell tumor

General Disease Information
BXGD Id	BXGD004132
Disease Name	Germ cell tumor
Disease CUI Id	C0205851
MeSH Codes	C04
Disease Class Name	Neoplasms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:14566
Disease Ontology Class Name	disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00142	BXGT003883	Thymidine kinase 2, mitochondrial	7084	reviewed	Kinase
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14727	BXGT004084	Apoptotic protease-activating factor 1	317	reviewed
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14965	BXGT004117	Aurora kinase A	6790	reviewed	Kinase
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15169	BXGT004134	Axin-1	8312	reviewed
O60566	BXGT004884	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	701	reviewed	Kinase
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75751	BXGT005150	Solute carrier family 22 member 3	6581	reviewed	Transporter
O96017	BXGT005415	Serine/threonine-protein kinase Chk2	11200	reviewed	Kinase
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04183	BXGT006166	Thymidine kinase, cytosolic	7083	reviewed	Kinase
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P06858	BXGT006515	Lipoprotein lipase	4023	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08620	BXGT006800	Fibroblast growth factor 4	2249	reviewed	Signaling
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10696	BXGT007603	Alkaline phosphatase, germ cell type	251	reviewed	Enzyme
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11169	BXGT007664	Solute carrier family 2, facilitated glucose transporter member 3	6515	reviewed	Transporter
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12830	BXGT007852	Cadherin-1	999	reviewed
P14635	BXGT008031	G2/mitotic-specific cyclin-B1	891	reviewed	Enzyme modulator
P14923	BXGT008069	Junction plakoglobin	3728	reviewed
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16070	BXGT008186	CD44 antigen	960	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P21583	BXGT008667	Kit ligand	4254	reviewed
P22392	BXGT008762	Nucleoside diphosphate kinase B	654364	reviewed	Kinase
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28347	BXGT009257	Transcriptional enhancer factor TEF-1	7003	reviewed	Transcription factor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35613	BXGT009856	Basigin	682	reviewed
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P37088	BXGT009961	Amiloride-sensitive sodium channel subunit alpha	6337	reviewed	Ion channel
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42330	BXGT010301	Aldo-keto reductase family 1 member C3	8644	reviewed	Enzyme
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49711	BXGT010728	Transcriptional repressor CTCF	10664	reviewed	Transcription factor
P49763	BXGT010737	Placenta growth factor	5228	reviewed	Signaling
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P68104	BXGT011575	Elongation factor 1-alpha 1	1915	reviewed	Enzyme
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q04828	BXGT012787	Aldo-keto reductase family 1 member C1	1645	reviewed	Enzyme
Q05516	BXGT012822	Zinc finger and BTB domain-containing protein 16	7704	reviewed	Transcription factor
Q13257	BXGT013333	Mitotic spindle assembly checkpoint protein MAD2A	4085	reviewed
Q13285	BXGT013335	Steroidogenic factor 1	2516	reviewed	Nuclear receptor
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16769	BXGT013665	Glutaminyl-peptide cyclotransferase	25797	reviewed	Enzyme
Q16790	BXGT013670	Carbonic anhydrase 9	768	reviewed
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q8TD08	BXGT018803	Mitogen-activated protein kinase 15	225689	reviewed	Kinase
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q96SB4	BXGT019740	SRSF protein kinase 1	6732	reviewed	Kinase
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9H3S7	BXGT020467	Tyrosine-protein phosphatase non-receptor type 23	25930	reviewed
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9P0U3	BXGT021292	Sentrin-specific protease 1	29843	reviewed	Enzyme
Q9UJW3	BXGT021732	DNA (cytosine-5)-methyltransferase 3-like	29947	reviewed
Q9UKV8	BXGT021752	Protein argonaute-2	27161	reviewed
Q9UM07	BXGT021771	Protein-arginine deiminase type-4	23569	reviewed
Q9UPY3	BXGT021802	Endoribonuclease Dicer	23405	reviewed	Enzyme
Q9UQF0	BXGT021812	Syncytin-1	30816	reviewed
Q9Y219	BXGT022206	Protein jagged-2	3714	reviewed
Q9Y5X9	BXGT022307	Endothelial lipase	9388	reviewed	Enzyme
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
P29590	BXGT024350	Protein PML	5371	reviewed
P21926	BXGT024578	CD9 antigen	928	reviewed
Q8IUN9	BXGT025263	C-type lectin domain family 10 member A	10462	reviewed	Receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}