adisease

Showing entry for Benign Neoplasm

General Disease Information
BXGD Id	BXGD003306
Disease Name	Benign Neoplasm
Disease CUI Id	C0086692
MeSH Codes	C04
Disease Class Name	Neoplasms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00255	BXGT003903	Menin	4221	reviewed
O14561	BXGT004071	Acyl carrier protein, mitochondrial	4706	reviewed	Transporter
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15392	BXGT004162	Baculoviral IAP repeat-containing protein 5	332	reviewed	Enzyme modulator
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O43464	BXGT004595	Serine protease HTRA2, mitochondrial	27429	reviewed
O43765	BXGT004621	Small glutamine-rich tetratricopeptide repeat-containing protein alpha	6449	reviewed
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	57016	reviewed	Enzyme
O95407	BXGT005380	Tumor necrosis factor receptor superfamily member 6B	8771	reviewed
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00326	BXGT005499	Alcohol dehydrogenase 1C	126	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00739	BXGT005633	Haptoglobin-related protein	3250	reviewed	Enzyme
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02788	BXGT005963	Lactotransferrin	4057	reviewed	Enzyme
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06703	BXGT006477	Protein S100-A6	6277	reviewed	Calcium-binding protein
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P07327	BXGT006598	Alcohol dehydrogenase 1A	124	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07355	BXGT006609	Annexin A2	302	reviewed
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08319	BXGT006764	Alcohol dehydrogenase 4	127	reviewed	Enzyme
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08670	BXGT006810	Vimentin	7431	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11387	BXGT007696	DNA topoisomerase 1	7150	reviewed	Enzyme
P11388	BXGT007697	DNA topoisomerase 2-alpha	7153	reviewed
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12830	BXGT007852	Cadherin-1	999	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14550	BXGT008019	Aldo-keto reductase family 1 member A1	10327	reviewed	Enzyme
P14616	BXGT008026	Insulin receptor-related protein	3645	reviewed	Kinase
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15336	BXGT008109	Cyclic AMP-dependent transcription factor ATF-2	1386	reviewed	Transcription factor
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16070	BXGT008186	CD44 antigen	960	reviewed
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18440	BXGT008404	Arylamine N-acetyltransferase 1	9	reviewed	Enzyme
P19113	BXGT008458	Histidine decarboxylase	3067	reviewed
P21359	BXGT008640	Neurofibromin	4763	reviewed	Enzyme modulator
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P22352	BXGT008758	Glutathione peroxidase 3	2878	reviewed	Enzyme
P22392	BXGT008762	Nucleoside diphosphate kinase B	654364	reviewed	Kinase
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P28332	BXGT009253	Alcohol dehydrogenase 6	130	reviewed	Enzyme
P29317	BXGT009331	Ephrin type-A receptor 2	1969	reviewed	Kinase
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30101	BXGT009402	Protein disulfide-isomerase A3	2923	reviewed
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31213	BXGT009515	3-oxo-5-alpha-steroid 4-dehydrogenase 2	6716	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31941	BXGT009585	DNA dC->dU-editing enzyme APOBEC-3A	200315	reviewed
P31948	BXGT009590	Stress-induced-phosphoprotein 1	10963	reviewed
P32241	BXGT009613	Vasoactive intestinal polypeptide receptor 1	7433	reviewed	G-protein coupled receptor
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35613	BXGT009856	Basigin	682	reviewed
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P47736	BXGT010579	Rap1 GTPase-activating protein 1	5909	reviewed	Enzyme modulator
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P50281	BXGT010788	Matrix metalloproteinase-14	4323	reviewed	Enzyme
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P54753	BXGT011073	Ephrin type-B receptor 3	2049	reviewed	Kinase
P55774	BXGT011124	C-C motif chemokine 18	6362	reviewed	Signaling
P55786	BXGT011125	Puromycin-sensitive aminopeptidase	9520	reviewed	Enzyme
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P78417	BXGT011843	Glutathione S-transferase omega-1	9446	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
Q00613	BXGT012540	Heat shock factor protein 1	3297	reviewed	Transcription factor
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q03405	BXGT012713	Urokinase plasminogen activator surface receptor	5329	reviewed
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q06710	BXGT012887	Paired box protein Pax-8	7849	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q08050	BXGT012958	Forkhead box protein M1	2305	reviewed
Q12756	BXGT013261	Kinesin-like protein KIF1A	547	reviewed	Cellular structure
Q12809	BXGT013267	Potassium voltage-gated channel subfamily H member 2	3757	reviewed	Ion channel
Q13309	BXGT013338	S-phase kinase-associated protein 2	6502	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13418	BXGT013351	Integrin-linked protein kinase	3611	reviewed	Kinase
Q13509	BXGT013366	Tubulin beta-3 chain	10381	reviewed	Cellular structure
Q13546	BXGT013372	Receptor-interacting serine/threonine-protein kinase 1	8737	reviewed	Kinase
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q13616	BXGT013381	Cullin-1	8454	reviewed	Enzyme
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16206	BXGT013623	Ecto-NOX disulfide-thiol exchanger 2	10495	reviewed	Enzyme
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16611	BXGT013644	Bcl-2 homologous antagonist/killer	578	reviewed	Signaling
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16828	BXGT013676	Dual specificity protein phosphatase 6	1848	reviewed
Q3YBR2	BXGT014542	Transforming growth factor beta regulator 1	84897	reviewed	Signaling
Q6ZN17	BXGT016631	Protein lin-28 homolog B	389421	reviewed
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8WYH8	BXGT019019	Inhibitor of growth protein 5	84289	reviewed	Nucleic acid binding
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92830	BXGT019379	Histone acetyltransferase KAT2A	2648	reviewed
Q92831	BXGT019380	Histone acetyltransferase KAT2B	8850	reviewed
Q92854	BXGT019385	Semaphorin-4D	10507	reviewed	Signaling
Q92887	BXGT019389	Canalicular multispecific organic anion transporter 1	1244	reviewed	Transporter
Q92905	BXGT019393	COP9 signalosome complex subunit 5	10987	reviewed	Enzyme
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96RE7	BXGT019725	Nucleus accumbens-associated protein 1	112939	reviewed
Q9NR12	BXGT021174	PDZ and LIM domain protein 7	9260	reviewed	Cellular structure
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UH17	BXGT021691	DNA dC->dU-editing enzyme APOBEC-3B	9582	reviewed	Enzyme
Q9UJ41	BXGT021723	Rab5 GDP/GTP exchange factor	27342	reviewed	Enzyme modulator
Q9UJU2	BXGT021730	Lymphoid enhancer-binding factor 1	51176	reviewed
Q9UK32	BXGT021736	Ribosomal protein S6 kinase alpha-6	27330	reviewed	Kinase
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9UPY3	BXGT021802	Endoribonuclease Dicer	23405	reviewed	Enzyme
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y2T6	BXGT022247	G-protein coupled receptor 55	9290	reviewed	G-protein coupled receptor
Q9Y5K2	BXGT022293	Kallikrein-4	9622	reviewed	Enzyme
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
Q13029	BXGT022688	PR domain zinc finger protein 2	7799	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
P35240	BXGT022927	Merlin	4771	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}