Showing entry for Ketohexokinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010769
Protein NameKetohexokinase
Uniport IdP50053
GeneKHK
Gene Id3795
DomainPfkB
Pfam PF00294  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
Biological Process GO:0006000 fructose metabolic process
Biological Process GO:0070873 regulation of glycogen metabolic process
Biological Process GO:0009750 response to fructose
Biological Process GO:0009749 response to glucose
Biological Process GO:0032868 response to insulin
Biological Process GO:0009744 response to sucrose
Biological Process GO:0010043 response to zinc ion
molecular function GO:0005524 ATP binding
molecular function GO:0004454 ketohexokinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-5652084 Fructose metabolism
R-HSA-5657562 Essential fructosuria
R-HSA-5663084 Diseases of carbohydrate metabolism
R-HSA-5668914 Diseases of metabolism
R-HSA-70350 Fructose catabolism
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016751 BXGD001077 Hereditary fructose intolerance syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0268160 BXGD005842 Deficiency of fructokinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0403823 BXGD008315 Asthenozoospermia Male Urogenital Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0920715 BXGD011473 Myocardial hypoxia
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1408247 BXGD013036 Renal disease (acute) NOS
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0006198 Citric acid 192.12
BXGC0039791 fructose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein