adisease

Showing entry for Hyperuricemia

General Disease Information
BXGD Id	BXGD009989
Disease Name	Hyperuricemia
Disease CUI Id	C0740394
MeSH Codes	C23
Disease Class Name	Pathological Conditions, Signs and Symptoms
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001939
Human Phenotype Ontology Term	Abnormality of metabolism/homeostasis
Disease Ontology Id	DOID:0014667
Disease Ontology Class Name	disease of metabolism
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O15244	BXGT004140	Solute carrier family 22 member 2	6582	reviewed	Transporter
O15439	BXGT004169	Multidrug resistance-associated protein 4	10257	reviewed	Transporter
O15553	BXGT004181	Pyrin	4210	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43826	BXGT004629	Glucose-6-phosphate exchanger SLC37A4	2542	reviewed	Transporter
O43868	BXGT004631	Sodium/nucleoside cotransporter 2	9153	reviewed	Transporter
O60256	BXGT004862	Phosphoribosyl pyrophosphate synthase-associated protein 2	5636	reviewed	Enzyme
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O95644	BXGT005389	Nuclear factor of activated T-cells, cytoplasmic 1	4772	reviewed	Transcription factor
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	3251	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02656	BXGT005913	Apolipoprotein C-III	345	reviewed
P02730	BXGT005935	Band 3 anion transport protein	6521	reviewed	Transporter
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05062	BXGT006305	Fructose-bisphosphate aldolase B	229	reviewed
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05154	BXGT006327	Plasma serine protease inhibitor	5104	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08397	BXGT006768	Porphobilinogen deaminase	3145	reviewed	Enzyme
P09467	BXGT006893	Fructose-1,6-bisphosphatase 1	2203	reviewed	Enzyme
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P12104	BXGT007773	Fatty acid-binding protein, intestinal	2169	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13945	BXGT007972	Beta-3 adrenergic receptor	155	reviewed	G-protein coupled receptor
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15735	BXGT008151	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	5261	reviewed	Kinase
P15941	BXGT008176	Mucin-1	4582	reviewed
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P22087	BXGT008729	rRNA 2'-O-methyltransferase fibrillarin	2091	reviewed	Enzyme
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24752	BXGT008993	Acetyl-CoA acetyltransferase, mitochondrial	38	reviewed	Enzyme
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P31639	BXGT009556	Sodium/glucose cotransporter 2	6524	reviewed	Transporter
P35914	BXGT009880	Hydroxymethylglutaryl-CoA lyase, mitochondrial	3155	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41161	BXGT010229	ETS translocation variant 5	2119	reviewed	Transcription factor
P41231	BXGT010240	P2Y purinoceptor 2	5029	reviewed	G-protein coupled receptor
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P46019	BXGT010498	Phosphorylase b kinase regulatory subunit alpha, liver isoform	5256	reviewed	Kinase
P47900	BXGT010595	P2Y purinoceptor 1	5028	reviewed	G-protein coupled receptor
P47989	BXGT010602	Xanthine dehydrogenase/oxidase	7498	reviewed	Enzyme
P49747	BXGT010732	Cartilage oligomeric matrix protein	1311	reviewed
P50053	BXGT010769	Ketohexokinase	3795	reviewed	Kinase
P51575	BXGT010861	P2X purinoceptor 1	5023	reviewed	Ion channel
P51787	BXGT010889	Potassium voltage-gated channel subfamily KQT member 1	3784	reviewed	Ion channel
P52758	BXGT010951	2-iminobutanoate/2-iminopropanoate deaminase	10247	reviewed
P56373	BXGT011164	P2X purinoceptor 3	5024	reviewed	Ion channel
P60891	BXGT011337	Ribose-phosphate pyrophosphokinase 1	5631	reviewed	Kinase
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P62736	BXGT011452	Actin, aortic smooth muscle	59	reviewed	Cellular structure
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P69891	BXGT011646	Hemoglobin subunit gamma-1	3047	reviewed
P69892	BXGT011647	Hemoglobin subunit gamma-2	3048	reviewed
P78330	BXGT011833	Phosphoserine phosphatase	5723	reviewed	Enzyme
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00610	BXGT012539	Clathrin heavy chain 1	1213	reviewed	Transporter
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q13093	BXGT013310	Platelet-activating factor acetylhydrolase	7941	reviewed	Enzyme
Q13237	BXGT013331	cGMP-dependent protein kinase 2	5593	reviewed	Kinase
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14397	BXGT013467	Glucokinase regulatory protein	2646	reviewed
Q14541	BXGT013481	Hepatocyte nuclear factor 4-gamma	3174	reviewed	Nuclear receptor
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q2TU34	BXGT014223	Fructose-1,6-bisphosphatase 1	2203	unreviewed
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q4U2R8	BXGT014891	Solute carrier family 22 member 6	9356	reviewed	Transporter
Q6DT37	BXGT016259	Serine/threonine-protein kinase MRCK gamma	55561	reviewed	Kinase
Q8TCC7	BXGT018794	Solute carrier family 22 member 8	9376	reviewed	Transporter
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96FL8	BXGT019660	Multidrug and toxin extrusion protein 1	55244	reviewed	Transporter
Q96JA1	BXGT019681	Leucine-rich repeats and immunoglobulin-like domains protein 1	26018	reviewed	Receptor
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96S37	BXGT019737	Solute carrier family 22 member 12	116085	reviewed	Transporter
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9NSA0	BXGT021202	Solute carrier family 22 member 11	55867	reviewed	Transporter
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9UBL9	BXGT021656	P2X purinoceptor 2	22953	reviewed	Ion channel
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9Y572	BXGT022289	Receptor-interacting serine/threonine-protein kinase 3	11035	reviewed	Kinase
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
Q96A54	BXGT024681	Adiponectin receptor protein 1	51094	reviewed	Receptor
P38646	BXGT024954	Stress-70 protein, mitochondrial	3313	reviewed
O14649	BXGT025486	Potassium channel subfamily K member 3	3777	reviewed	Ion channel

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}