Showing entry for Ubiquitin-conjugating enzyme E2 K


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011357
Protein NameUbiquitin-conjugating enzyme E2 K
Uniport IdP61086
GeneUBE2K
Gene Id3093
DomainUBA; UQ_con
Pfam PF00627   PF00179  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0010994 free ubiquitin chain polymerization
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0060340 positive regulation of type I interferon-mediated signaling pathway
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0061631 ubiquitin conjugating enzyme activity
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0004842 ubiquitin-protein transferase activity
molecular function GO:0034450 ubiquitin-ubiquitin ligase activity
cellular component GO:0005829 cytosol
cellular component GO:0032433 filopodium tip
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-8852135 Protein ubiquitination
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162635 BXGD003964 Angelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0221043 BXGD004377 Liddle Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0263314 BXGD005286 Pemphigus and fogo selvagem Skin and Connective Tissue Diseases; Immune System Diseases
C0270968 BXGD006143 Limb-girdle muscular dystrophy type 2H Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1336078 BXGD012830 Papillary renal cell carcinoma, sporadic Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1735591 BXGD013712 VACTERL Association Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Cardiovascular Diseases
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein