Showing entry for Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011563
Protein NameSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Uniport IdP67775
GenePPP2CA
Gene Id5515
DomainMetallophos
Pfam PF00149  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03015 mRNA surveillance pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
4. Cellular Processes 4.1 Transport and catabolism hsa04136 Autophagy - other
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05142 Chagas disease (American trypanosomiasis)
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006672 ceramide metabolic process
Biological Process GO:0000188 inactivation of MAPK activity
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0007498 mesoderm development
Biological Process GO:0007084 mitotic nuclear envelope reassembly
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0010719 negative regulation of epithelial to mesenchymal transition
Biological Process GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0070262 peptidyl-serine dephosphorylation
Biological Process GO:0035970 peptidyl-threonine dephosphorylation
Biological Process GO:1904528 positive regulation of microtubule binding
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0040008 regulation of growth
Biological Process GO:1904526 regulation of microtubule binding
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0030111 regulation of Wnt signaling pathway
Biological Process GO:0010288 response to lead ion
Biological Process GO:0010033 response to organic substance
Biological Process GO:0008380 RNA splicing
Biological Process GO:0019932 second-messenger-mediated signaling
molecular function GO:0050811 GABA receptor binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004721 phosphoprotein phosphatase activity
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0004722 protein serine/threonine phosphatase activity
molecular function GO:0048156 tau protein binding
cellular component GO:0000775 chromosome, centromeric region
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0000159 protein phosphatase type 2A complex
cellular component GO:0000922 spindle pole
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-113510 E2F mediated regulation of DNA replication
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-141424 Amplification of signal from the kinetochores
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-163685 Integration of energy metabolism
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-180024 DARPP-32 events
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-190236 Signaling by FGFR
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195258 RHO GTPase Effectors
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-198753 ERK/MAPK targets
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-202670 ERKs are inactivated
R-HSA-212436 Generic Transcription Pathway
R-HSA-2465910 MASTL Facilitates Mitotic Progression
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-418346 Platelet homeostasis
R-HSA-418594 G alpha (i) signalling events
R-HSA-432142 Platelet sensitization by LDL
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-450294 MAP kinase activation
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-4839744 truncated APC mutants destabilize the destruction complex
R-HSA-4839748 AMER1 mutants destabilize the destruction complex
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-68875 Mitotic Prophase
R-HSA-68877 Mitotic Prometaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-68886 M Phase
R-HSA-69206 G1/S Transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69236 G1 Phase
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953854 Metabolism of RNA
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0023015 BXGD001601 Language Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0232466 BXGD004543 Feeding difficulties
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241726 BXGD005110 Delayed ability to walk
C0265529 BXGD005542 Plagiocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266999 BXGD005725 Vesicular Stomatitis Infections; Stomatognathic Diseases; Animal Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0344530 BXGD007688 Congenital keratoglobus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393706 BXGD008126 Early infantile epileptic encephalopathy with suppression bursts Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0424731 BXGD008542 Single transverse palmar crease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0426429 BXGD008564 Broad nasal tip
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0853662 BXGD010975 Oestrogen deficiency
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1654637 BXGD013484 androgen independent prostate cancer
C1842688 BXGD014532 Hypoplasia of the brainstem
C1849089 BXGD015004 Broad forehead
C1858036 BXGD015763 Periorbital fullness
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861324 BXGD016029 Short philtrum
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936904 BXGD018150 Opitz GBBB Syndrome, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Stomatognathic Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022810 BXGD021005 Abnormality of nervous system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000284 alpha-Tocopherol 430.71
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein