Showing entry for Cytochrome P450 4A11


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012680
Protein NameCytochrome P450 4A11
Uniport IdQ02928
GeneCYP4A11
Gene Id1579
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00071 Fatty acid degradation
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0019373 epoxygenase P450 pathway
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0046456 icosanoid biosynthetic process
Biological Process GO:0001822 kidney development
Biological Process GO:0048252 lauric acid metabolic process
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0001676 long-chain fatty acid metabolic process
Biological Process GO:0097267 omega-hydroxylase P450 pathway
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0031408 oxylipin biosynthetic process
Biological Process GO:0032305 positive regulation of icosanoid secretion
Biological Process GO:0003095 pressure natriuresis
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0003091 renal water homeostasis
Biological Process GO:0055078 sodium ion homeostasis
molecular function GO:0018685 alkane 1-monooxygenase activity
molecular function GO:0008392 arachidonic acid epoxygenase activity
molecular function GO:0008391 arachidonic acid monooxygenase activity
molecular function GO:0070330 aromatase activity
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0050051 leukotriene-B4 20-monooxygenase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211935 Fatty acids
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211958 Miscellaneous substrates
R-HSA-211979 Eicosanoids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023891 BXGD001714 Liver Cirrhosis, Alcoholic Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Chemically-Induced Disorders
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027719 BXGD002027 Nephrosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0264657 BXGD005409 Renal sclerosis with hypertension Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0268790 BXGD006039 Renal vascular disorder Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0337438 BXGD007159 Glucose measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0495706 BXGD009038 elevated blood glucose level
C0848548 BXGD010881 hypertensive nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0052224 Ginsenoside Rh2 622.44
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein