Showing entry for Spliceosome RNA helicase DDX39B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013397
Protein NameSpliceosome RNA helicase DDX39B
Uniport IdQ13838
GeneDDX39B
Gene Id7919
DomainDEAD; Helicase_C
Pfam PF00270   PF00271  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
2. Genetic Information Processing 2.2 Translation hsa03015 mRNA surveillance pathway
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001889 liver development
Biological Process GO:0031124 mRNA 3'-end processing
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:2000002 negative regulation of DNA damage checkpoint
Biological Process GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:2000573 positive regulation of DNA biosynthetic process
Biological Process GO:0032786 positive regulation of DNA-templated transcription, elongation
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0006405 RNA export from nucleus
Biological Process GO:0010501 RNA secondary structure unwinding
Biological Process GO:0008380 RNA splicing
Biological Process GO:0000245 spliceosomal complex assembly
Biological Process GO:0046784 viral mRNA export from host cell nucleus
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0043008 ATP-dependent protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0003723 RNA binding
molecular function GO:0008186 RNA-dependent ATPase activity
molecular function GO:0003724 RNA helicase activity
molecular function GO:0030621 U4 snRNA binding
molecular function GO:0017070 U6 snRNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0016363 nuclear matrix
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005681 spliceosomal complex
cellular component GO:0000346 transcription export complex
Reactome
Pathway Id Pathway Name
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73856 RNA Polymerase II Transcription Termination
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007930 BXGD000502 Chagas Cardiomyopathy Infections; Cardiovascular Diseases
C0010691 BXGD000685 Cystinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014518 BXGD000921 Toxic Epidermal Necrolysis Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023343 BXGD001635 Leprosy Infections
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0024537 BXGD001786 Malaria, Vivax Infections
C0024788 BXGD001803 Marburg Virus Disease Infections; Animal Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0038325 BXGD002745 Stevens-Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0497169 BXGD009054 hiv-infection/aids Infections
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1836230 BXGD014099 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
C1836231 BXGD014100 HIV-1, RESISTANCE TO
C1836232 BXGD014101 ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
C1836233 BXGD014102 AIDS, PROGRESSION TO
C2062441 BXGD016897 Influenza A
C2747816 BXGD017577 Complicated malaria Infections
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0004266 2-Propanol 60.1
BXGC0004277 Acetic acid 60.05
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein