adisease

Showing entry for Nephritis

General Disease Information
BXGD Id	BXGD002022
Disease Name	Nephritis
Disease CUI Id	C0027697
MeSH Codes	C13 C12
Disease Class Name	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000119 HP:0002715
Human Phenotype Ontology Term	Abnormality of the genitourinary system; Abnormality of the immune system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00148	BXGT003884	ATP-dependent RNA helicase DDX39A	10212	reviewed
O00182	BXGT003889	Galectin-9	3965	reviewed	Signaling
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43707	BXGT004616	Alpha-actinin-4	81	reviewed
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O75460	BXGT005127	Serine/threonine-protein kinase/endoribonuclease IRE1	2081	reviewed	Kinase
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00736	BXGT005632	Complement C1r subcomponent	715	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02795	BXGT005968	Metallothionein-2	4502	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04054	BXGT006136	Phospholipase A2	5319	reviewed	Enzyme
P04406	BXGT006207	Glyceraldehyde-3-phosphate dehydrogenase	2597	reviewed	Enzyme
P04731	BXGT006251	Metallothionein-1A	4489	reviewed
P04732	BXGT006252	Metallothionein-1E	4493	reviewed
P04733	BXGT006253	Metallothionein-1F	4494	reviewed
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P07355	BXGT006609	Annexin A2	302	reviewed
P07438	BXGT006625	Metallothionein-1B	4490	reviewed
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08572	BXGT006791	Collagen alpha-2(IV) chain	1284	reviewed
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08603	BXGT006798	Complement factor H	3075	reviewed
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P09012	BXGT006849	U1 small nuclear ribonucleoprotein A	6626	reviewed	Nucleic acid binding
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09936	BXGT006943	Ubiquitin carboxyl-terminal hydrolase isozyme L1	7345	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P10827	BXGT007623	Thyroid hormone receptor alpha	7067	reviewed	Nuclear receptor
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13612	BXGT007928	Integrin alpha-4	3676	reviewed
P13640	BXGT007935	Metallothionein-1G	4495	reviewed
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16050	BXGT008184	Arachidonate 15-lipoxygenase	246	reviewed	Enzyme
P16070	BXGT008186	CD44 antigen	960	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16871	BXGT008269	Interleukin-7 receptor subunit alpha	3575	reviewed	Receptor
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P20810	BXGT008602	Calpastatin	831	reviewed
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P23219	BXGT008837	Prostaglandin G/H synthase 1	5742	reviewed	Enzyme
P24071	BXGT008945	Immunoglobulin alpha Fc receptor	2204	reviewed	Receptor
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P29017	BXGT009305	T-cell surface glycoprotein CD1c	911	reviewed
P29400	BXGT009343	Collagen alpha-5(IV) chain	1287	reviewed
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P30530	BXGT009431	Tyrosine-protein kinase receptor UFO	558	reviewed	Kinase
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35579	BXGT009852	Myosin-9	4627	reviewed
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43116	BXGT010357	Prostaglandin E2 receptor EP2 subtype	5732	reviewed	G-protein coupled receptor
P48039	BXGT010607	Melatonin receptor type 1A	4543	reviewed	G-protein coupled receptor
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51589	BXGT010867	Cytochrome P450 2J2	1573	reviewed
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61604	BXGT011380	10 kDa heat shock protein, mitochondrial	3336	reviewed	Chaperone
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P62314	BXGT011420	Small nuclear ribonucleoprotein Sm D1	6632	reviewed	Nucleic acid binding
P63104	BXGT011499	14-3-3 protein zeta/delta	7534	reviewed	Chaperone
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P80294	BXGT011890	Metallothionein-1H	4496	reviewed
P80297	BXGT011891	Metallothionein-1X	4501	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
P82251	BXGT011971	b(0,+)-type amino acid transporter 1	11136	reviewed	Transporter
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q05397	BXGT012815	Focal adhesion kinase 1	5747	reviewed	Kinase
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q12931	BXGT013282	Heat shock protein 75 kDa, mitochondrial	10131	reviewed	Chaperone
Q13838	BXGT013397	Spliceosome RNA helicase DDX39B	7919	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14393	BXGT013466	Growth arrest-specific protein 6	2621	reviewed	Extracellular structure
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15485	BXGT013574	Ficolin-2	2220	reviewed	Signaling
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16566	BXGT013639	Calcium/calmodulin-dependent protein kinase type IV	814	reviewed	Kinase
Q16827	BXGT013675	Receptor-type tyrosine-protein phosphatase O	5800	reviewed
Q5S007	BXGT015650	Leucine-rich repeat serine/threonine-protein kinase 2	120892	reviewed	Kinase
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q7Z7D3	BXGT017262	V-set domain-containing T-cell activation inhibitor 1	79679	reviewed	Enzyme modulator
Q8IV61	BXGT018340	Ras guanyl-releasing protein 3	25780	reviewed	Enzyme modulator
Q8N339	BXGT018503	Metallothionein-1M	4499	reviewed
Q8TDU6	BXGT018814	G-protein coupled bile acid receptor 1	151306	reviewed	G-protein coupled receptor
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96D96	BXGT019638	Voltage-gated hydrogen channel 1	84329	reviewed	Ion channel
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q99519	BXGT019928	Sialidase-1	4758	reviewed	Enzyme
Q99683	BXGT019947	Mitogen-activated protein kinase kinase kinase 5	4217	reviewed	Kinase
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BYF1	BXGT020186	Angiotensin-converting enzyme 2	59272	reviewed	Enzyme
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9C000	BXGT020206	NACHT, LRR and PYD domains-containing protein 1	22861	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H3M7	BXGT020462	Thioredoxin-interacting protein	10628	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NYK1	BXGT021258	Toll-like receptor 7	51284	reviewed
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UM07	BXGT021771	Protein-arginine deiminase type-4	23569	reviewed
Q9UNN8	BXGT021791	Endothelial protein C receptor	10544	reviewed	Enzyme modulator
Q9UQF0	BXGT021812	Syncytin-1	30816	reviewed
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y5K2	BXGT022293	Kallikrein-4	9622	reviewed	Enzyme
Q9Y6K9	BXGT022333	NF-kappa-B essential modulator	8517	reviewed	Kinase
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q01543	BXGT023137	Friend leukemia integration 1 transcription factor	2313	reviewed	Transcription factor
Q01955	BXGT023255	Collagen alpha-3(IV) chain	1285	reviewed
P31994	BXGT023298	Low affinity immunoglobulin gamma Fc region receptor II-b	2213	reviewed	Cell adhesion
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
Q13007	BXGT023883	Interleukin-24	11009	reviewed
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
P07320	BXGT026150	Gamma-crystallin D	1421	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}