Showing entry for Metalloreductase STEAP3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016142
Protein NameMetalloreductase STEAP3
Uniport IdQ658P3
GeneSTEAP3
Gene Id55240
DomainF420_oxidored; Ferric_reduct
Pfam PF03807   PF01794  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04115 p53 signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007049 cell cycle
Biological Process GO:0015677 copper ion import
Biological Process GO:0055072 iron ion homeostasis
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0009306 protein secretion
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0033572 transferrin transport
molecular function GO:0008823 cupric reductase activity
molecular function GO:0052851 ferric-chelate reductase (NADPH) activity
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005768 endosome
cellular component GO:0010008 endosome membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005771 multivesicular body
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-382551 Transport of small molecules
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-917937 Iron uptake and transport
R-HSA-917977 Transferrin endocytosis and recycling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001623 BXGD000066 Adrenal gland hypofunction Endocrine System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002884 BXGD000143 Hypochromic anemia Hemic and Lymphatic Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0085576 BXGD003188 Iron-Refractory Iron Deficiency Anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0086942 BXGD003315 Rous Sarcoma Neoplasms; Infections; Animal Diseases
C0151900 BXGD003500 Serum iron raised Nutritional and Metabolic Diseases
C0221263 BXGD004427 Cafe-au-Lait Spots Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0221281 BXGD004436 Poikilocytosis
C0238644 BXGD004949 Anemia, severe Hemic and Lymphatic Diseases
C0241013 BXGD005075 Increased serum ferritin
C0271901 BXGD006277 Microcytic hypochromic anemia (disorder) Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333912 BXGD006973 Hypochromatism
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0456070 BXGD008863 Growth delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0855790 BXGD011088 Decreased mean corpuscular volume
C0858867 BXGD011196 Reticulocytopenia
C0919785 BXGD011441 Decreased transferrin saturation
C1269955 BXGD012005 Tumor Cell Invasion
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1848701 BXGD014967 Elevated hepatic transaminase
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673913 BXGD017231 Anemia, Hypochromic Microcytic, With Iron Overload Hemic and Lymphatic Diseases
C2675920 BXGD017316 Anisopoikilocytosis
C3808920 BXGD019560 ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD 2
C3839280 BXGD019772 High grade serous carcinoma
C4022891 BXGD021028 Elevated hepatic iron concentration
C4023032 BXGD021077 Dysplastic erythropoesis
C4025819 BXGD021808 Abnormality of the hypothalamus-pituitary axis
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein