adisease

Showing entry for Hypogonadism

General Disease Information
BXGD Id	BXGD001447
Disease Name	Hypogonadism
Disease CUI Id	C0020619
MeSH Codes	C19
Disease Class Name	Endocrine System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000119 HP:0000818
Human Phenotype Ontology Term	Abnormality of the genitourinary system; Abnormality of the endocrine system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	2563	reviewed	Ion channel
O15119	BXGT004128	T-box transcription factor TBX3	6926	reviewed	Transcription factor
O15197	BXGT004136	Ephrin type-B receptor 6	2051	reviewed	Kinase
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
O60313	BXGT004871	Dynamin-like 120 kDa protein, mitochondrial	4976	reviewed	Enzyme modulator
O60551	BXGT004882	Glycylpeptide N-tetradecanoyltransferase 2	9397	reviewed	Enzyme
O60931	BXGT004911	Cystinosin	1497	reviewed
O75643	BXGT005142	U5 small nuclear ribonucleoprotein 200 kDa helicase	23020	reviewed
O75688	BXGT005145	Protein phosphatase 1B	5495	reviewed	Enzyme
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	8654	reviewed
O95237	BXGT005361	Lecithin retinol acyltransferase	9227	reviewed
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
O95470	BXGT005382	Sphingosine-1-phosphate lyase 1	8879	reviewed
P00480	BXGT005551	Ornithine carbamoyltransferase, mitochondrial	5009	reviewed
P00742	BXGT005636	Coagulation factor X	2159	reviewed	Enzyme
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01148	BXGT005739	Progonadoliberin-1	2796	reviewed
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05108	BXGT006317	Cholesterol side-chain cleavage enzyme, mitochondrial	1583	reviewed
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P07510	BXGT006631	Acetylcholine receptor subunit gamma	1146	reviewed	Ion channel
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09884	BXGT006937	DNA polymerase alpha catalytic subunit	5422	reviewed
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P10828	BXGT007624	Thyroid hormone receptor beta	7068	reviewed	Nuclear receptor
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12271	BXGT007786	Retinaldehyde-binding protein 1	6017	reviewed	Transporter
P14060	BXGT007978	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	3283	reviewed	Enzyme
P16499	BXGT008238	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	5145	reviewed
P17612	BXGT008322	cAMP-dependent protein kinase catalytic subunit alpha	5566	reviewed	Kinase
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P20794	BXGT008600	Serine/threonine-protein kinase MAK	4117	reviewed	Kinase
P20839	BXGT008608	Inosine-5'-monophosphate dehydrogenase 1	3614	reviewed	Enzyme
P22748	BXGT008802	Carbonic anhydrase 4	762	reviewed
P23945	BXGT008931	Follicle-stimulating hormone receptor	2492	reviewed	G-protein coupled receptor
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29622	BXGT009370	Kallistatin	5267	reviewed	Enzyme modulator
P29973	BXGT009389	cGMP-gated cation channel alpha-1	1259	reviewed	Ion channel
P32245	BXGT009614	Melanocortin receptor 4	4160	reviewed	G-protein coupled receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35913	BXGT009879	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	5158	reviewed
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P50213	BXGT010779	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	3419	reviewed	Enzyme
P51843	BXGT010897	Nuclear receptor subfamily 0 group B member 1	190	reviewed	Nuclear receptor
P51955	BXGT010908	Serine/threonine-protein kinase Nek2	4751	reviewed	Kinase
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
P82279	BXGT011972	Protein crumbs homolog 1	23418	reviewed
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q07837	BXGT012943	Neutral and basic amino acid transport protein rBAT	6519	reviewed	Transporter
Q08499	BXGT012988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	5144	reviewed
Q09013	BXGT013023	Myotonin-protein kinase	1760	reviewed	Kinase
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q13303	BXGT013336	Voltage-gated potassium channel subunit beta-2	8514	reviewed	Ion channel
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13976	BXGT013409	cGMP-dependent protein kinase 1	5592	reviewed	Kinase
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q15223	BXGT013551	Nectin-1	5818	reviewed
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q658P3	BXGT016142	Metalloreductase STEAP3	55240	reviewed
Q6P2Q9	BXGT016446	Pre-mRNA-processing-splicing factor 8	10594	reviewed	Nucleic acid binding
Q6PCD5	BXGT016464	E3 ubiquitin-protein ligase RFWD3	55159	reviewed	Enzyme
Q6ZVN8	BXGT016641	Hemojuvelin	148738	reviewed
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8IWS0	BXGT018356	PHD finger protein 6	84295	reviewed	Nucleic acid binding
Q8IYD8	BXGT018367	Fanconi anemia group M protein	57697	reviewed	Enzyme
Q8WWY3	BXGT019006	U4/U6 small nuclear ribonucleoprotein Prp31	26121	reviewed	Nucleic acid binding
Q8WZA1	BXGT019024	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	55624	reviewed
Q92834	BXGT019381	X-linked retinitis pigmentosa GTPase regulator	6103	reviewed
Q93009	BXGT019455	Ubiquitin carboxyl-terminal hydrolase 7	7874	reviewed	Enzyme
Q96NR8	BXGT019701	Retinol dehydrogenase 12	145226	reviewed	Enzyme
Q99928	BXGT019975	Gamma-aminobutyric acid receptor subunit gamma-3	2567	reviewed	Ion channel
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9H0F7	BXGT020435	ADP-ribosylation factor-like protein 6	84100	reviewed
Q9H6X2	BXGT020486	Anthrax toxin receptor 1	84168	reviewed	Receptor
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9NPD8	BXGT021152	Ubiquitin-conjugating enzyme E2 T	29089	reviewed
Q9NPI8	BXGT021161	Fanconi anemia group F protein	2188	reviewed
Q9NW38	BXGT021230	E3 ubiquitin-protein ligase FANCL	55120	reviewed	Enzyme
Q9UHF0	BXGT021699	Tachykinin-3	6866	reviewed
Q9UI95	BXGT021714	Mitotic spindle assembly checkpoint protein MAD2B	10459	reviewed
Q9Y4U1	BXGT022285	Methylmalonic aciduria and homocystinuria type C protein	25974	reviewed
Q9Y5X4	BXGT022306	Photoreceptor-specific nuclear receptor	10002	reviewed	Nuclear receptor
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q7Z624	BXGT022792	Calmodulin-lysine N-methyltransferase	79823	reviewed
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
O43837	BXGT024635	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	3420	reviewed	Enzyme
A6NHR9	BXGT024875	Structural maintenance of chromosomes flexible hinge domain-containing protein 1	23347	reviewed
Q9UNE7	BXGT025000	E3 ubiquitin-protein ligase CHIP	10273	reviewed
P28715	BXGT025675	DNA repair protein complementing XP-G cells	2073	reviewed
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
O43172	BXGT026158	U4/U6 small nuclear ribonucleoprotein Prp4	9128	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}