Showing entry for Serine/threonine-protein kinase/endoribonuclease IRE2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016871
Protein NameSerine/threonine-protein kinase/endoribonuclease IRE2
Uniport IdQ76MJ5
GeneERN2
Gene Id10595
DomainPkinase; Ribonuc_2-5A
Pfam PF00069   PF06479  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0030263 apoptotic chromosome condensation
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0030968 endoplasmic reticulum unfolded protein response
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0006397 mRNA processing
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0016075 rRNA catabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0004519 endonuclease activity
molecular function GO:0004521 endoribonuclease activity
molecular function GO:0000287 magnesium ion binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0051082 unfolded protein binding
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:1990604 IRE1-TRAF2-ASK1 complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0027651 BXGD002009 Neoplasms Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein