Showing entry for Lysine-specific demethylase 3B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016998
Protein NameLysine-specific demethylase 3B
Uniport IdQ7LBC6
GeneKDM3B
Gene Id51780
DomainJmjC
Pfam PF02373  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033169 histone H3-K9 demethylation
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0072718 response to cisplatin
molecular function GO:0016209 antioxidant activity
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0051213 dioxygenase activity
molecular function GO:0032454 histone demethylase activity (H3-K9 specific)
molecular function GO:0046872 metal ion binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0000785 chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-3214842 HDMs demethylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0236773 BXGD004827 Depressed bipolar I disorder Mental Disorders
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0274869 BXGD006374 Toxic effect of heavy metal Chemically-Induced Disorders
C0349588 BXGD007933 Short stature
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0424574 BXGD008534 Duration of sleep
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1859592 BXGD015912 ATRICHIA WITH PAPULAR LESIONS Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919142 BXGD017867 Short Stature, CTCAE
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0014312 Isonicotinic Acids 123.03
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein