Showing entry for Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018791
Protein NamePhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Uniport IdQ8TBX8
GenePIP4K2C
Gene Id79837
DomainPIP5K
Pfam PF01504  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:2000786 positive regulation of autophagosome assembly
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
molecular function GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
cellular component GO:0005776 autophagosome
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-162582 Signal Transduction
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-556833 Metabolism of lipids
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8847453 Synthesis of PIPs in the nucleus
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001545 Harmine 212.25
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein