Showing entry for Polycystic Kidney Diseases


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001576
Disease NamePolycystic Kidney Diseases
Disease CUI IdC0022680
MeSH Codes C16   C13   C12  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000119  
Human Phenotype Ontology TermAbnormality of the genitourinary system
Disease Ontology Id DOID:630   DOID:7   DOID:225  
Disease Ontology Class Namegenetic disease; disease of anatomical entity; syndrome
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15305 BXGT004152 Phosphomannomutase 2 5373 reviewed Enzyme
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O95747 BXGT005393 Serine/threonine-protein kinase OSR1 9943 reviewed Kinase
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00751 BXGT005643 Complement factor B 629 reviewed
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01833 BXGT005788 Polymeric immunoglobulin receptor 5284 reviewed
P02748 BXGT005940 Complement component C9 735 reviewed
P02818 BXGT005969 Osteocalcin 632 reviewed
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P05089 BXGT006310 Arginase-1 383 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P06280 BXGT006433 Alpha-galactosidase A 2717 reviewed
P06454 BXGT006441 Prothymosin alpha 5757 reviewed
P07148 BXGT006559 Fatty acid-binding protein, liver 2168 reviewed
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P07858 BXGT006689 Cathepsin B 1508 reviewed Enzyme
P08047 BXGT006720 Transcription factor Sp1 6667 reviewed Nucleic acid binding
P08100 BXGT006725 Rhodopsin 6010 reviewed G-protein coupled receptor
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09668 BXGT006914 Pro-cathepsin H 1512 reviewed Enzyme
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P15336 BXGT008109 Cyclic AMP-dependent transcription factor ATF-2 1386 reviewed Transcription factor
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16581 BXGT008245 E-selectin 6401 reviewed
P17643 BXGT008323 5,6-dihydroxyindole-2-carboxylic acid oxidase 7306 reviewed Enzyme
P18089 BXGT008379 Alpha-2B adrenergic receptor 151 reviewed G-protein coupled receptor
P18754 BXGT008423 Regulator of chromosome condensation 1104 reviewed
P18846 BXGT008430 Cyclic AMP-dependent transcription factor ATF-1 466 reviewed
P19174 BXGT008467 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 5335 reviewed Enzyme
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 6198 reviewed Kinase
P23786 BXGT008906 Carnitine O-palmitoyltransferase 2, mitochondrial 1376 reviewed Enzyme
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29320 BXGT009332 Ephrin type-A receptor 3 2042 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30304 BXGT009418 M-phase inducer phosphatase 1 993 reviewed Enzyme
P30307 BXGT009421 M-phase inducer phosphatase 3 995 reviewed Enzyme
P30518 BXGT009428 Vasopressin V2 receptor 554 reviewed G-protein coupled receptor
P30874 BXGT009475 Somatostatin receptor type 2 6752 reviewed G-protein coupled receptor
P31391 BXGT009535 Somatostatin receptor type 4 6754 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35348 BXGT009814 Alpha-1A adrenergic receptor 148 reviewed G-protein coupled receptor
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38117 BXGT010027 Electron transfer flavoprotein subunit beta 2109 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P42226 BXGT010288 Signal transducer and activator of transcription 6 6778 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P43116 BXGT010357 Prostaglandin E2 receptor EP2 subtype 5732 reviewed G-protein coupled receptor
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P47712 BXGT010577 Cytosolic phospholipase A2 5321 reviewed Enzyme
P48147 BXGT010620 Prolyl endopeptidase 5550 reviewed Enzyme
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49674 BXGT010725 Casein kinase I isoform epsilon 1454 reviewed
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50542 BXGT010808 Peroxisomal targeting signal 1 receptor 5830 reviewed Transporter
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P61769 BXGT011383 Beta-2-microglobulin 567 reviewed Immune response
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P68363 BXGT011594 Tubulin alpha-1B chain 10376 reviewed Cellular structure
P69905 BXGT011649 Hemoglobin subunit alpha 3040 reviewed
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q08345 BXGT012982 Epithelial discoidin domain-containing receptor 1 780 reviewed Kinase
Q13163 BXGT013321 Dual specificity mitogen-activated protein kinase kinase 5 5607 reviewed Kinase
Q13164 BXGT013322 Mitogen-activated protein kinase 7 5598 reviewed Kinase
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q13541 BXGT013371 Eukaryotic translation initiation factor 4E-binding protein 1 1978 reviewed Nucleic acid binding
Q13563 BXGT013377 Polycystin-2 5311 reviewed Ion channel
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14697 BXGT013501 Neutral alpha-glucosidase AB 23193 reviewed Enzyme
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15139 BXGT013546 Serine/threonine-protein kinase D1 5587 reviewed Kinase
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q68DC2 BXGT016189 Ankyrin repeat and SAM domain-containing protein 6 203286 reviewed
Q7Z494 BXGT017254 Nephrocystin-3 27031 reviewed
Q8NCM8 BXGT018548 Cytoplasmic dynein 2 heavy chain 1 79659 reviewed Enzyme
Q8TBX8 BXGT018791 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 79837 reviewed Kinase
Q8TDS5 BXGT018813 Oxoeicosanoid receptor 1 165140 reviewed G-protein coupled receptor
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 151306 reviewed G-protein coupled receptor
Q8TDV0 BXGT018815 Probable G-protein coupled receptor 151 134391 reviewed G-protein coupled receptor
Q96L34 BXGT019689 MAP/microtubule affinity-regulating kinase 4 57787 reviewed Kinase
Q96PY6 BXGT019712 Serine/threonine-protein kinase Nek1 4750 reviewed Kinase
Q99572 BXGT019935 P2X purinoceptor 7 5027 reviewed Ion channel
Q99623 BXGT019941 Prohibitin-2 11331 reviewed
Q99653 BXGT019945 Calcineurin B homologous protein 1 11261 reviewed
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 2034 reviewed Transcription factor
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9BZL6 BXGT020199 Serine/threonine-protein kinase D2 25865 reviewed Kinase
Q9HBA0 BXGT020516 Transient receptor potential cation channel subfamily V member 4 59341 reviewed Ion channel
Q9NRR6 BXGT021193 Phosphatidylinositol polyphosphate 5-phosphatase type IV 56623 reviewed
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9ULV1 BXGT021764 Frizzled-4 8322 reviewed G-protein coupled receptor
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9Y2R2 BXGT022243 Tyrosine-protein phosphatase non-receptor type 22 26191 reviewed
Q16134 BXGT022664 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 2110 reviewed Enzyme
Q92482 BXGT022676 Aquaporin-3 360 reviewed Ion channel
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
P17535 BXGT023437 Transcription factor jun-D 3727 reviewed Transcription factor
P53539 BXGT023438 Protein fosB 2354 reviewed Transcription factor
Q9H694 BXGT024116 Protein bicaudal C homolog 1 80114 reviewed Transporter
Q8IZA0 BXGT025026 Dyslexia-associated protein KIAA0319-like protein 79932 reviewed
Q9GZV5 BXGT025439 WW domain-containing transcription regulator protein 1 25937 reviewed Enzyme modulator
Q86SG6 BXGT026136 Serine/threonine-protein kinase Nek8 284086 reviewed Kinase
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease