Showing entry for Polyribonucleotide nucleotidyltransferase 1, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018799
Protein NamePolyribonucleotide nucleotidyltransferase 1, mitochondrial
Uniport IdQ8TCS8
GenePNPT1
Gene Id87178
DomainKH_1; PNPase; RNase_PH; RNase_PH_C; S1
Pfam PF00013   PF03726   PF01138   PF03725   PF00575  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03018 RNA degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0097421 liver regeneration
Biological Process GO:0000958 mitochondrial mRNA catabolic process
Biological Process GO:0097222 mitochondrial mRNA polyadenylation
Biological Process GO:0000965 mitochondrial RNA 3'-end processing
Biological Process GO:0000964 mitochondrial RNA 5'-end processing
Biological Process GO:0000957 mitochondrial RNA catabolic process
Biological Process GO:0000963 mitochondrial RNA processing
Biological Process GO:0070584 mitochondrion morphogenesis
Biological Process GO:0071850 mitotic cell cycle arrest
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0045926 negative regulation of growth
Biological Process GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process
Biological Process GO:2000627 positive regulation of miRNA catabolic process
Biological Process GO:0000962 positive regulation of mitochondrial RNA catabolic process
Biological Process GO:0061014 positive regulation of mRNA catabolic process
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0070207 protein homotrimerization
Biological Process GO:0043457 regulation of cellular respiration
Biological Process GO:2000772 regulation of cellular senescence
Biological Process GO:0051591 response to cAMP
Biological Process GO:0060416 response to growth hormone
Biological Process GO:0006401 RNA catabolic process
Biological Process GO:0035927 RNA import into mitochondrion
Biological Process GO:0043631 RNA polyadenylation
Biological Process GO:0035928 rRNA import into mitochondrion
molecular function GO:0000175 3'-5'-exoribonuclease activity
molecular function GO:0035198 miRNA binding
molecular function GO:0034046 poly(G) binding
molecular function GO:0008266 poly(U) RNA binding
molecular function GO:0004654 polyribonucleotide nucleotidyltransferase activity
molecular function GO:0003723 RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0045025 mitochondrial degradosome
cellular component GO:0005758 mitochondrial intermembrane space
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0042788 polysomal ribosome
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019553 BXGD001333 Hip Contracture Musculoskeletal Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023264 BXGD001625 Leigh Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152115 BXGD003544 Lingual-Facial-Buccal Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0456070 BXGD008863 Growth delay
C0541794 BXGD009262 Skeletal muscle atrophy
C0557874 BXGD009444 Global developmental delay
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0949856 BXGD011588 Oxidative Phosphorylation Deficiencies Nutritional and Metabolic Diseases
C0949857 BXGD011589 Mitochondrial Respiratory Chain Deficiencies Nutritional and Metabolic Diseases
C1167918 BXGD011779 Increased CSF lactate
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1824925 BXGD013765 DEAFNESS, AUTOSOMAL RECESSIVE 70
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1845245 BXGD014730 Lower limb hypertonia
C1846647 BXGD014833 DEAFNESS, AUTOSOMAL RECESSIVE (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854387 BXGD015396 Type 1 muscle fiber predominance
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857640 BXGD015726 Decreased nerve conduction velocity
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1864580 BXGD016235 Type 2 muscle fiber atrophy
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2751582 BXGD017726 Mitochondrial respiratory chain defects
C3554129 BXGD019201 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 13
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4023342 BXGD021158 Gastrostomy tube feeding in infancy
C4023607 BXGD021226 Abnormal corpus striatum morphology
C4024944 BXGD021491 Profound static encephalopathy
C4025597 BXGD021685 Subsarcolemmal accumulations of abnormally shaped mitochondria
C4073152 BXGD022050 Elevated CSF neopterin level
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein