Showing entry for Retinol dehydrogenase 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019372
Protein NameRetinol dehydrogenase 5
Uniport IdQ92781
GeneRDH5
Gene Id5959
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0050896 response to stimulus
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0008202 steroid metabolic process
Biological Process GO:0007601 visual perception
molecular function GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
molecular function GO:0047023 androsterone dehydrogenase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004745 retinol dehydrogenase activity
cellular component GO:0044297 cell body
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-2187338 Visual phototransduction
R-HSA-2453864 Retinoid cycle disease events
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-2474795 Diseases associated with visual transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-5365859 RA biosynthesis pathway
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9675143 Diseases of the neuronal system
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015398 BXGD000984 Eye Diseases, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0024440 BXGD001774 Macular Edema, Cystoid Eye Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0034951 BXGD002498 Refractive Errors Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0162532 BXGD003951 Variegate Porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0239119 BXGD004963 Lenticonus
C0241688 BXGD005107 Peripheral visual field loss
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0271084 BXGD006159 Exudative age-related macular degeneration Eye Diseases
C0311338 BXGD006878 Fundus Albipunctatus Eye Diseases
C0339508 BXGD007256 Hereditary macular dystrophy
C0339535 BXGD007263 Night blindness, congenital stationary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423420 BXGD008483 Absent foveal reflex
C0423421 BXGD008484 Atrophic macular change
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0730290 BXGD009946 Cone Dystrophy Eye Diseases
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0730362 BXGD009961 Disorder of macula of retina Eye Diseases
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1306122 BXGD012355 Oguchi disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1405854 BXGD013028 Retinitis punctata albescens (disorder) Eye Diseases
C1536085 BXGD013334 Geographic Atrophy Eye Diseases
C1839364 BXGD014371 Progressive visual loss
C1857644 BXGD015728 Retinal pigment epithelial mottling
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2237660 BXGD016962 exudative macular degeneration Eye Diseases
C2751492 BXGD017718 AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C3151111 BXGD018397 Abnormal light- and dark-adapted electroretinogram
C3278975 BXGD018749 Attenuation of retinal blood vessels
C3495915 BXGD019011 Delayed dark adaptation
C3551052 BXGD019144 Night blindness, stationary
C3665342 BXGD019277 Progressive Cone Dystrophy Eye Diseases
C4016746 BXGD020368 FUNDUS ALBIPUNCTATUS, AUTOSOMAL RECESSIVE
C4024760 BXGD021408 Progressive visual field defects
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4025843 BXGD021823 Abnormality of refraction
C4072991 BXGD022029 Yellow/white lesions of the retina
C4551633 BXGD023378 Pigmentary retinal dystrophy Eye Diseases
C4703439 BXGD023647 Abnormality of fundus pigmentation
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047568 Retinol 286.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein