Showing entry for Neutral ceramidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021180
Protein NameNeutral ceramidase
Uniport IdQ9NR71
GeneASAH2
Gene Id56624
DomainCeramidase_alk; Ceramidse_alk_C
Pfam PF04734   PF17048  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00600 Sphingolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0046513 ceramide biosynthetic process
Biological Process GO:0046514 ceramide catabolic process
Biological Process GO:0006672 ceramide metabolic process
Biological Process GO:0044241 lipid digestion
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:2001234 negative regulation of apoptotic signaling pathway
Biological Process GO:0007346 regulation of mitotic cell cycle
Biological Process GO:0046512 sphingosine biosynthetic process
Biological Process GO:0006670 sphingosine metabolic process
molecular function GO:0005509 calcium ion binding
molecular function GO:0102121 ceramidase activity
molecular function GO:0017040 N-acylsphingosine amidohydrolase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005901 caveola
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018852 BXGD001240 Heavy Chain Disease Immune System Diseases; Hemic and Lymphatic Diseases
C0018854 BXGD001241 gamma-Chain Disease Immune System Diseases; Hemic and Lymphatic Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0021071 BXGD001478 Immunoproliferative Small Intestinal Disease Digestive System Diseases; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0202236 BXGD004086 Triglycerides measurement
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1456868 BXGD013128 Diabetic foot ulcer Skin and Connective Tissue Diseases; Endocrine System Diseases; Cardiovascular Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3805043 BXGD019457 Vascular cognitive impairment
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0006198 Citric acid 192.12
BXGC0018397 beta-1,4-mannan 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein