Showing entry for Lymphoproliferative Disorders


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001767
Disease NameLymphoproliferative Disorders
Disease CUI IdC0024314
MeSH Codes C20   C15  
Disease Class NameImmune System Diseases; Hemic and Lymphatic Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0002664   HP:0001871  
Human Phenotype Ontology TermNeoplasm; Abnormality of blood and blood-forming tissues
Disease Ontology Id DOID:630   DOID:7   DOID:14566  
Disease Ontology Class Namegenetic disease; disease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00459 BXGT003924 Phosphatidylinositol 3-kinase regulatory subunit beta 5296 reviewed Enzyme modulator
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O43521 BXGT004598 Bcl-2-like protein 11 10018 reviewed
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O43929 BXGT004638 Origin recognition complex subunit 4 5000 reviewed Nucleic acid binding
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O75015 BXGT005095 Low affinity immunoglobulin gamma Fc region receptor III-B 2215 reviewed Cell adhesion
O95267 BXGT005368 RAS guanyl-releasing protein 1 10125 reviewed Enzyme modulator
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02008 BXGT005832 Hemoglobin subunit zeta 3050 reviewed
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05155 BXGT006328 Plasma protease C1 inhibitor 710 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06239 BXGT006427 Tyrosine-protein kinase Lck 3932 reviewed Kinase
P06734 BXGT006491 Low affinity immunoglobulin epsilon Fc receptor 2208 reviewed Receptor
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09769 BXGT006917 Tyrosine-protein kinase Fgr 2268 reviewed Kinase
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P13612 BXGT007928 Integrin alpha-4 3676 reviewed
P14618 BXGT008027 Pyruvate kinase PKM 5315 reviewed Kinase
P14784 BXGT008054 Interleukin-2 receptor subunit beta 3560 reviewed Receptor
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P18827 BXGT008427 Syndecan-1 6382 reviewed Extracellular structure
P19525 BXGT008492 Interferon-induced, double-stranded RNA-activated protein kinase 5610 reviewed Kinase
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P20273 BXGT008557 B-cell receptor CD22 933 reviewed
P20718 BXGT008595 Granzyme H 2999 reviewed Enzyme
P21580 BXGT008666 Tumor necrosis factor alpha-induced protein 3 7128 reviewed Enzyme
P22681 BXGT008795 E3 ubiquitin-protein ligase CBL 867 reviewed Enzyme
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23297 BXGT008848 Protein S100-A1 6271 reviewed Calcium-binding protein
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P25791 BXGT009072 Rhombotin-2 4005 reviewed
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha 5295 reviewed Kinase
P28072 BXGT009231 Proteasome subunit beta type-6 5694 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P28908 BXGT009302 Tumor necrosis factor receptor superfamily member 8 943 reviewed
P29597 BXGT009367 Non-receptor tyrosine-protein kinase TYK2 7297 reviewed Kinase
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P31785 BXGT009577 Cytokine receptor common subunit gamma 3561 reviewed Signaling
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 7433 reviewed G-protein coupled receptor
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P33991 BXGT009745 DNA replication licensing factor MCM4 4173 reviewed Enzyme
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41182 BXGT010231 B-cell lymphoma 6 protein 604 reviewed
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43403 BXGT010385 Tyrosine-protein kinase ZAP-70 7535 reviewed Kinase
P43405 BXGT010386 Tyrosine-protein kinase SYK 6850 reviewed Kinase
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P51677 BXGT010876 C-C chemokine receptor type 3 1232 reviewed G-protein coupled receptor
P51679 BXGT010877 C-C chemokine receptor type 4 1233 reviewed G-protein coupled receptor
P52333 BXGT010928 Tyrosine-protein kinase JAK3 3718 reviewed Kinase
P52952 BXGT010966 Homeobox protein Nkx-2.5 1482 reviewed Transcription factor
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P55040 BXGT011099 GTP-binding protein GEM 2669 reviewed
P55263 BXGT011115 Adenosine kinase 132 reviewed Kinase
P60033 BXGT011286 CD81 antigen 975 reviewed
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P63146 BXGT011504 Ubiquitin-conjugating enzyme E2 B 7320 reviewed
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP 331 reviewed Enzyme modulator
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q07108 BXGT012919 Early activation antigen CD69 969 reviewed
Q08881 BXGT013012 Tyrosine-protein kinase ITK/TSK 3702 reviewed Kinase
Q12918 BXGT013280 Killer cell lectin-like receptor subfamily B member 1 3820 reviewed
Q13191 BXGT013325 E3 ubiquitin-protein ligase CBL-B 868 reviewed Enzyme
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 10682 reviewed Enzyme
Q16611 BXGT013644 Bcl-2 homologous antagonist/killer 578 reviewed Signaling
Q16658 BXGT013651 Fascin 6624 reviewed Cellular structure
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q8NE86 BXGT018552 Calcium uniporter protein, mitochondrial 90550 reviewed Ion channel
Q8TAF3 BXGT018786 WD repeat-containing protein 48 57599 reviewed
Q8WXI8 BXGT019014 C-type lectin domain family 4 member D 338339 reviewed
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96D31 BXGT019635 Calcium release-activated calcium channel protein 1 84876 reviewed Ion channel
Q96RJ3 BXGT019729 Tumor necrosis factor receptor superfamily member 13C 115650 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BTP7 BXGT020126 Fanconi anemia core complex-associated protein 24 91442 reviewed
Q9BXL7 BXGT020171 Caspase recruitment domain-containing protein 11 84433 reviewed
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NR12 BXGT021174 PDZ and LIM domain protein 7 9260 reviewed Cellular structure
Q9NR71 BXGT021180 Neutral ceramidase 56624 reviewed
Q9NRW4 BXGT021196 Dual specificity protein phosphatase 22 56940 reviewed
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9P246 BXGT021298 Stromal interaction molecule 2 57620 reviewed
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UIB8 BXGT021715 SLAM family member 5 8832 reviewed
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9UQF0 BXGT021812 Syncytin-1 30816 reviewed
Q9Y263 BXGT022220 Phospholipase A-2-activating protein 9373 reviewed Enzyme modulator
Q9Y275 BXGT022223 Tumor necrosis factor ligand superfamily member 13B 10673 reviewed
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P07954 BXGT023939 Fumarate hydratase, mitochondrial 2271 reviewed Enzyme
P31358 BXGT025061 CAMPATH-1 antigen 1043 reviewed
Q96SD1 BXGT025929 Protein artemis 64421 reviewed
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease