Showing entry for Protection of telomeres protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021220
Protein NameProtection of telomeres protein 1
Uniport IdQ9NUX5
GenePOT1
Gene Id25913
DomainPOT1; POT1PC
Pfam PF02765   PF16686  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032508 DNA duplex unwinding
Biological Process GO:0070200 establishment of protein localization to telomere
Biological Process GO:0051974 negative regulation of telomerase activity
Biological Process GO:0032211 negative regulation of telomere maintenance via telomerase
Biological Process GO:1905776 positive regulation of DNA helicase activity
Biological Process GO:0060383 positive regulation of DNA strand elongation
Biological Process GO:0051096 positive regulation of helicase activity
Biological Process GO:0051973 positive regulation of telomerase activity
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:1905774 regulation of DNA helicase activity
Biological Process GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0032210 regulation of telomere maintenance via telomerase
Biological Process GO:0032202 telomere assembly
Biological Process GO:0016233 telomere capping
Biological Process GO:0007004 telomere maintenance via telomerase
Biological Process GO:0061820 telomeric D-loop disassembly
molecular function GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding
molecular function GO:0017151 DEAD/H-box RNA helicase binding
molecular function GO:1990955 G-rich single-stranded DNA binding
molecular function GO:0098505 G-rich strand telomeric DNA binding
molecular function GO:0043047 single-stranded telomeric DNA binding
molecular function GO:0010521 telomerase inhibitor activity
molecular function GO:0061821 telomeric D-loop binding
molecular function GO:0042162 telomeric DNA binding
cellular component GO:0000781 chromosome, telomeric region
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0000783 nuclear telomere cap complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0070187 shelterin complex
Reactome
Pathway Id Pathway Name
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-1221632 Meiotic synapsis
R-HSA-1474165 Reproduction
R-HSA-1500620 Meiosis
R-HSA-157579 Telomere Maintenance
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-171319 Telomere Extension By Telomerase
R-HSA-174411 Polymerase switching on the C-strand of the telomere
R-HSA-174414 Processive synthesis on the C-strand of the telomere
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis
R-HSA-174430 Telomere C-strand synthesis initiation
R-HSA-174437 Removal of the Flap Intermediate from the C-strand
R-HSA-180786 Extension of Telomeres
R-HSA-2262752 Cellular responses to stress
R-HSA-2559583 Cellular Senescence
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-73884 Base Excision Repair
R-HSA-73884 Base Excision Repair
R-HSA-73886 Chromosome Maintenance
R-HSA-73894 DNA Repair
R-HSA-73894 DNA Repair
R-HSA-73927 Depurination
R-HSA-73927 Depurination
R-HSA-73928 Depyrimidination
R-HSA-73929 Base-Excision Repair, AP Site Formation
R-HSA-73929 Base-Excision Repair, AP Site Formation
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9670095 Inhibition of DNA recombination at telomere
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004403 BXGD000272 Autosome Abnormalities Pathological Conditions, Signs and Symptoms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008625 BXGD000558 Chromosome Aberrations Pathological Conditions, Signs and Symptoms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0016689 BXGD001073 Freckles Skin and Connective Tissue Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018923 BXGD001248 Hemangiosarcoma Neoplasms
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023009 BXGD001598 Speech and language disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0026470 BXGD001903 Monoclonal Gammopathy of Undetermined Significance Immune System Diseases; Hemic and Lymphatic Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027960 BXGD002062 Nevus Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036920 BXGD002645 Sezary Syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0078918 BXGD003055 Albinism, Oculocutaneous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0234133 BXGD004624 Extrapyramidal sign
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0259783 BXGD005221 mixed gliomas Neoplasms
C0262587 BXGD005259 Parathyroid Adenoma Neoplasms; Endocrine System Diseases
C0279070 BXGD006625 Adult Oligodendroglioma Neoplasms
C0280475 BXGD006749 Childhood Oligodendroglioma Neoplasms
C0334590 BXGD007129 Anaplastic Oligodendroglioma Neoplasms
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0750927 BXGD010254 Apraxia, Developmental Verbal Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0855095 BXGD011071 Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C0969687 BXGD011593 Autosomal Chromosome Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1456781 BXGD013123 Benign melanocytic nevus Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512419 BXGD013189 Hereditary Melanoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1839259 BXGD014363 Bulbo-Spinal Atrophy, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C1883018 BXGD016594 Severe Aplastic Anemia Hemic and Lymphatic Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C1963094 BXGD016681 Dry Skin, CTCAE
C2030354 BXGD016886 Cardiac Angiosarcoma
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2314896 BXGD017019 Familial Atypical Mole Melanoma Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C2675080 BXGD017270 Li-Fraumeni-Like Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3280492 BXGD018831 TUMOR PREDISPOSITION SYNDROME
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C3896673 BXGD020041 Familial Nonmedullary Thyroid Gland Carcinoma
C4014476 BXGD020147 MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 10
C4021976 BXGD020852 Abnormality of the lymphatic system
C4225278 BXGD022208 GLIOMA SUSCEPTIBILITY 9
C4511622 BXGD023008 Familial malignant melanoma of skin Neoplasms; Skin and Connective Tissue Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733330 BXGD023917 familial chronic lymphocytic leukemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002591 Potassium 39.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein