Showing entry for Pyridoxine-5'-phosphate oxidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021228
Protein NamePyridoxine-5'-phosphate oxidase
Uniport IdQ9NVS9
GenePNPO
Gene Id55163
DomainPNP_phzG_C; Putative_PNPOx
Pfam PF10590   PF01243  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00750 Vitamin B6 metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042823 pyridoxal phosphate biosynthetic process
Biological Process GO:0008615 pyridoxine biosynthetic process
Biological Process GO:0042816 vitamin B6 metabolic process
molecular function GO:0010181 FMN binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0004733 pyridoxamine-phosphate oxidase activity
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0239154 BXGD004967 High pitched cry Behavior and Behavior Mechanisms
C0240595 BXGD005045 Rotary Nystagmus Eye Diseases; Nervous System Diseases
C0241816 BXGD005115 Global brain atrophy
C0266781 BXGD005710 Abnormal amniotic fluid
C0270823 BXGD006112 Petit mal status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0272027 BXGD006296 Pyridoxine-responsive sideroblastic anemia Hemic and Lymphatic Diseases
C0311335 BXGD006877 Grand Mal Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0393734 BXGD008131 Complex Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0456070 BXGD008863 Growth delay
C0497202 BXGD009055 Abnormal ocular motility
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0549400 BXGD009377 Low APGAR score
C0557874 BXGD009444 Global developmental delay
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751522 BXGD010488 Status Epilepticus, Subclinical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751523 BXGD010489 Non-Convulsive Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751524 BXGD010490 Simple Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1291312 BXGD012208 Deficiency of oxidase
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1386048 BXGD012950 Intrauterine retardation
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1833308 BXGD013910 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V Nervous System Diseases
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1849508 BXGD015060 EPILEPSY, PYRIDOXINE-DEPENDENT Nervous System Diseases
C1850456 BXGD015146 Progressive microcephaly
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1864723 BXGD016246 Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C1969156 BXGD016761 EEG with burst suppression
C2674608 BXGD017250 Feeding difficulties in infancy
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4025095 BXGD021556 Hypoargininemia
C4280803 BXGD022407 Decreased CSF homovanillic acid
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein