Showing entry for Curcumin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0013582
Compound NameCurcumin
Structure
FormulaC21H20O6
InchiKeyZIUSSTSXXLLKKK-KOBPDPAPSA-N
SMILESCOc1cc(/C=C/C(=C/C(=O)/C=C/c2ccc(c(c2)OC)O)/O)ccc1O
InchiInChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13-
IUPAC(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one
Molecular Weight368.13
Pubchem Id5281767
Chembl IdCHEMBL116438
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 191758
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 - 8200 - -
reviewed BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN - 12800 - -
CHEMBL CHEMBL116438
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Km '=' 36000 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '>' 20 %
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 reviewed Epigenetic regulator DNMT1 Activity - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Potency - 6513 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 48 %
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 '=' 800 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 34 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 7079 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 115 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 - - -
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Activity '=' 150 nM/s
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 35090 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 3162 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP IC50 '>' 250000 nM
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Thermal melting change '=' 3 degrees C
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 43 %
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 9300 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 31622 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 10000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 33498 nM
P43071 BXGT010352 Multidrug resistance protein CDR1 reviewed - CDR1 IC50 '=' 14200 nM
P15840 BXGT008161 CPG DNA methylase reviewed - sssIM Activity - - -
Q76353 BXGT016849 Integrase unreviewed - IC50 '=' 40000 nM
Q76353 BXGT016849 Integrase unreviewed - IC50 '=' 30000 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 12589 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 35481 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 35481 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 70 %
Q9NR96 BXGT021181 Toll-like receptor 9 reviewed - TLR9 IC50 '=' 15266 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 '=' 5700 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition - - -
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 2410 nM
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A Ki '=' 10250 nM
P0C6X7 BXGT007440 Replicase polyprotein 1ab reviewed - rep Ki - - -
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 44668 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 150000 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 '=' 5300 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Activity - - -
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '>' 40000 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR FC '=' 8 -
P10997 BXGT007643 Islet amyloid polypeptide reviewed Signaling IAPP Inhibition - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 25918 nM
P43071 BXGT010352 Multidrug resistance protein CDR1 reviewed - CDR1 Inhibition - - -
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 15848 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 8100 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 73 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 42 %
Q04760 BXGT012782 Lactoylglutathione lyase reviewed - GLO1 Ki '=' 10300 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 22387 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 11000 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 25118 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 43 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 56 %
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Km '=' 164000 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat '=' 5 /s
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 '=' 8500 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Inhibition - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Inhibition - - -
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Activity - - -
Q76353 BXGT016849 Integrase unreviewed - IC50 '=' 51 ug.mL-1
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 3900 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Potency - 23109 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Activity '=' 160 nM/s
P15840 BXGT008161 CPG DNA methylase reviewed - sssIM IC50 '=' 30 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '=' 7410 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Inhibition '=' 59 %
P03469 BXGT006080 Neuraminidase reviewed - NA IC50 '=' 8100 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Ki '=' 0 nM
P43071 BXGT010352 Multidrug resistance protein CDR1 reviewed - CDR1 Activity - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 8000 nM
Q9YQ12 BXGT022394 Protease unreviewed - protease IC50 '=' 100000 nM
P45452 BXGT010462 Collagenase 3 reviewed Enzyme MMP13 IC50 '=' 10300 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 15848 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 800 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 25118 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 35481 nM
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 Ki '=' 539 nM
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 Ki '=' 539 nM
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 Ki '=' 539 nM
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 Ki '=' 539 nM
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 Ki '=' 539 nM
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 Ki '=' 539 nM
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 Ki '=' 539 nM
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 Ki '=' 539 nM
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Ki '=' 539 nM
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 Ki '=' 539 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 Ki '=' 539 nM
Q99873 BXGT019972 Protein arginine N-methyltransferase 1 reviewed Epigenetic regulator PRMT1 IC50 '=' 1070000 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 50118 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 15848 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 15848 nM
P37058 BXGT009956 Testosterone 17-beta-dehydrogenase 3 reviewed - HSD17B3 IC50 '=' 67300 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat '=' 6 /s
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 11060 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 600 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 25118 nM
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE EC50 '=' 8810 nM
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Activity - - -
O54939 BXGT004737 Testosterone 17-beta-dehydrogenase 3 reviewed - Hsd17b3 IC50 '=' 2300 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 18356 nM
Q99N23 BXGT019994 Carbonic anhydrase 15 reviewed - Ca15 Ki '=' 5090 nM
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES IC50 '=' 1200 nM
B4URE7 BXGT002145 Hemagglutinin unreviewed - HA Activity '=' 0 -
Q9HC98 BXGT020528 Serine/threonine-protein kinase Nek6 reviewed Kinase NEK6 Thermal melting change '=' 0 degrees C
Q13043 BXGT013307 Serine/threonine-protein kinase 4 reviewed Kinase STK4 Thermal melting change '=' 5 degrees C
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Thermal melting change '=' 3 degrees C
P37058 BXGT009956 Testosterone 17-beta-dehydrogenase 3 reviewed - HSD17B3 Inhibition - - -
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 50118 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 15848 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 25118 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 25118 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 80 %
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat '=' 4 /s
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Km '=' 43000 nM
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A IC50 '=' 34000 nM
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A Inhibition - - -
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 19952 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 44668 nM
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Inhibition '=' 35 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 24 %
Q09013 BXGT013023 Myotonin-protein kinase reviewed Kinase DMPK Thermal melting change '=' 1 degrees C
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat/Km '=' 4 /uM/s
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat/Km '=' 5 /uM/s
Q92993 BXGT019403 Histone acetyltransferase KAT5 reviewed - KAT5 IC50 '>' 200000 nM
Q04760 BXGT012782 Lactoylglutathione lyase reviewed - GLO1 Ki '=' 10000 nM
O43293 BXGT004584 Death-associated protein kinase 3 reviewed Kinase DAPK3 Thermal melting change '=' 1 degrees C
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 52000 nM
P17865 BXGT008349 Cell division protein FtsZ reviewed - ftsZ IC50 '=' 30000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 - - -
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 Ki '=' 9940 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 80 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '>' 100000 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 5623 nM
Q9S446 BXGT021560 Class A sortase SrtA unreviewed - srtA IC50 '=' 13 ug.mL-1
Q8N1Q1 BXGT018499 Carbonic anhydrase 13 reviewed - CA13 Ki '=' 6850 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 31622 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 31622 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 10000 nM
O54939 BXGT004737 Testosterone 17-beta-dehydrogenase 3 reviewed - Hsd17b3 IC50 '=' 9000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 64 %
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Inhibition '=' 30 %
P15144 BXGT008087 Aminopeptidase N reviewed Enzyme ANPEP IC50 '=' 10000 nM
P15145 BXGT008088 Aminopeptidase N reviewed - ANPEP IC50 '=' 15500 nM
Q8HY88 BXGT018198 Potassium channel subfamily K member 2 unreviewed - KCNK2 IC50 '=' 930 nM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ki '=' 4970 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 31622 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 12589 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 19952 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 '=' 4300 nM
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A IC50 '=' 21000 nM
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A IC50 '=' 33000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Inhibition - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR EC50 '=' 20000 nM
P10997 BXGT007643 Islet amyloid polypeptide reviewed Signaling IAPP TIME '=' 408 hr
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 IC50 '=' 19250 nM
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 Activity - - -
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 reviewed Transcription factor SMAD2 Inhibition - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 79200 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 51 %
P50233 BXGT010784 Corticosteroid 11-beta-dehydrogenase isozyme 2 reviewed - Hsd11b2 Inhibition '=' 14939 %
P16232 BXGT008207 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed - Hsd11b1 IC50 '=' 4125 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 '=' 15000 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 140000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 2 %
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '=' 44100 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 3480 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Km '=' 104000 nM
P07451 BXGT006627 Carbonic anhydrase 3 reviewed - CA3 Ki '=' 11300 nM
Q9Y2D0 BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed - CA5B Ki '=' 9460 nM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 4050 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Ki '=' 11730 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 30000 nM
P30291 BXGT009417 Wee1-like protein kinase reviewed Kinase WEE1 Inhibition - - -
Q00536 BXGT012535 Cyclin-dependent kinase 16 reviewed Kinase CDK16 Thermal melting change '=' 0 degrees C
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 '=' 40000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 50300 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 22387 nM
Q5VLE3 BXGT015884 RmtA unreviewed - rmtA IC50 '=' 1100000 nM
P43071 BXGT010352 Multidrug resistance protein CDR1 reviewed - CDR1 IC50 '=' 40000 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 25118 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '=' 16300 nM
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '>' 400000 nM
A0A0C5K5S3 BXGT000138 Fluoroquinolone resistance protein unreviewed - mdeA MIC '=' 256 ug.mL-1
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '>' 100000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Inhibition '=' 61 %
P10997 BXGT007643 Islet amyloid polypeptide reviewed Signaling IAPP Activity '=' 15 /day
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 12350 nM
P13726 BXGT007950 Tissue factor reviewed Receptor F3 IC50 '=' 199 nM
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT Activity - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '>' 100000 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 60 %
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat/Km '=' 6 /uM/s
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 22387 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Inhibition - - -
P28845 BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed - HSD11B1 IC50 '=' 15983 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 51 %
B4URE7 BXGT002145 Hemagglutinin unreviewed - HA Activity '=' 6 -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 20 %
Q39829 BXGT014381 Lipoxygenase unreviewed - Inhibition '=' 68 %
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 Potency - 35481 nM
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA IC50 '=' 20900 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 IC50 '=' 20900 nM
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 IC50 '=' 20900 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 500 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 44668 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 29092 nM
P35228 BXGT009800 Nitric oxide synthase, inducible reviewed - NOS2 IC50 '=' 6000 nM
P16232 BXGT008207 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed - Hsd11b1 IC50 '=' 3921 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA FC '=' 8 -
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Activity - - -
P48443 BXGT010631 Retinoic acid receptor RXR-gamma reviewed Nuclear receptor RXRG Activity - - -
P28702 BXGT009287 Retinoic acid receptor RXR-beta reviewed Nuclear receptor RXRB Activity - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 '=' 8600 nM
Q99816 BXGT019966 Tumor susceptibility gene 101 protein reviewed Enzyme TSG101 Potency - 31622 nM
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD EC50 '=' 10670 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 22387 nM
O54939 BXGT004737 Testosterone 17-beta-dehydrogenase 3 reviewed - Hsd17b3 Inhibition - - -
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 1200 nM
Q9QUK6 BXGT021375 Toll-like receptor 4 reviewed - Tlr4 IC50 '=' 6000 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 15848 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 29855 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 31622 nM
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ EC50 '=' 11080 nM
P43071 BXGT010352 Multidrug resistance protein CDR1 reviewed - CDR1 Km '=' 5870 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 30199 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 8800 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Inhibition - - -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Inhibition - - -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Inhibition - - -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Inhibition - - -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Inhibition - - -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Inhibition - - -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Inhibition - - -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Inhibition - - -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Inhibition - - -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Inhibition - - -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Inhibition - - -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Inhibition - - -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Inhibition - - -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Inhibition - - -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Inhibition - - -
P0AEK4 BXGT007320 Enoyl-[acyl-carrier-protein] reductase [NADH] FabI reviewed - fabI Activity - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Activity - - -
P0C6X7 BXGT007440 Replicase polyprotein 1ab reviewed - rep IC50 '=' 23500 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 28183 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 28183 nM
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B reviewed - DNMT3B Inhibition '=' 80 %
Q13555 BXGT013375 Calcium/calmodulin-dependent protein kinase type II subunit gamma reviewed Kinase CAMK2G Thermal melting change '=' 0 degrees C
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 10000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 52 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 57500 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 82 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 42 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 39810 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Activity - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Imax '=' 35 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Imax '=' 50 %
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 reviewed Kinase ERBB3 Inhibition - - -
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 reviewed Kinase ERBB4 Inhibition - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Inhibition - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Inhibition - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 51 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 2 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 53 %
B4URE7 BXGT002145 Hemagglutinin unreviewed - HA Activity '=' 2 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 51 %
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Activity - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 50 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 81050 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 32196 nM
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES Inhibition - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '=' 380 nM
Q92793 BXGT019374 CREB-binding protein reviewed - CREBBP IC50 '=' 25000 nM
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '=' 25000 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Inhibition '=' 97 %
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA IC50 '=' 8000 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 IC50 '=' 8000 nM
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 IC50 '=' 8000 nM
C5ISA2 BXGT002518 Tubulin alpha chain unreviewed - TUBA4A IC50 '=' 26600 nM
P10997 BXGT007643 Islet amyloid polypeptide reviewed Signaling IAPP TIME '=' 290 hr
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta reviewed Nucleic acid binding STAT1 Inhibition - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 28695 nM
P80365 BXGT011895 Corticosteroid 11-beta-dehydrogenase isozyme 2 reviewed Enzyme HSD11B2 Inhibition '=' 15696 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' -2 %
P58335 BXGT011233 Anthrax toxin receptor 2 reviewed Receptor ANTXR2 IC50 '>' 300000 nM
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A IC50 '=' 13000 nM
P10696 BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG IC50 '=' 63500 nM
P10276 BXGT007553 Retinoic acid receptor alpha reviewed Nuclear receptor RARA Activity - - -
P10826 BXGT007622 Retinoic acid receptor beta reviewed Nuclear receptor RARB Activity - - -
P13631 BXGT007929 Retinoic acid receptor gamma reviewed Nuclear receptor RARG Activity - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 58 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 29 %
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Inhibition '=' 41 %
Q86V86 BXGT017617 Serine/threonine-protein kinase pim-3 reviewed - PIM3 Thermal melting change '=' 6 degrees C
O94804 BXGT005334 Serine/threonine-protein kinase 10 reviewed Kinase STK10 Thermal melting change '=' 6 degrees C
O75716 BXGT005147 Serine/threonine-protein kinase 16 reviewed Kinase STK16 Thermal melting change '=' 0 degrees C
O00506 BXGT003932 Serine/threonine-protein kinase 25 reviewed Kinase STK25 Thermal melting change '=' 4 degrees C
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '=' 6500 nM
Q16566 BXGT013639 Calcium/calmodulin-dependent protein kinase type IV reviewed Kinase CAMK4 Thermal melting change '=' 2 degrees C
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Thermal melting change '=' 4 degrees C
P52564 BXGT010932 Dual specificity mitogen-activated protein kinase kinase 6 reviewed Kinase MAP2K6 Thermal melting change '=' 4 degrees C
Q13554 BXGT013374 Calcium/calmodulin-dependent protein kinase type II subunit beta reviewed Kinase CAMK2B Thermal melting change '=' 1 degrees C
Q00532 BXGT012532 Cyclin-dependent kinase-like 1 reviewed Kinase CDKL1 Thermal melting change '=' 3 degrees C
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 19952 nM
P28845 BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed - HSD11B1 IC50 '=' 4501 nM
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A IC50 '=' 45000 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat '=' 2 /s
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 Activity '=' 52 %
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 Activity '=' 52 %
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 Activity '=' 52 %
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 Activity '=' 52 %
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 Activity '=' 52 %
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 Activity '=' 52 %
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 Activity '=' 52 %
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 Activity '=' 52 %
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Activity '=' 52 %
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 Activity '=' 52 %
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 Activity '=' 52 %
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Inhibition - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Inhibition - - -
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Inhibition - - -
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Inhibition - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 22387 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Inhibition - - -
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 IC50 '=' 24500 nM
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Thermal melting change '=' 3 degrees C
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 35481 nM
Q8IU85 BXGT018333 Calcium/calmodulin-dependent protein kinase type 1D reviewed Kinase CAMK1D Thermal melting change '=' 2 degrees C
Q9UEE5 BXGT021671 Serine/threonine-protein kinase 17A reviewed Kinase STK17A Thermal melting change '=' 7 degrees C
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 35481 nM
P14679 BXGT008039 Tyrosinase reviewed Enzyme TYR IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Inhibition - - -
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A Thermal melting change '=' 0 degrees C
P78368 BXGT011840 Casein kinase I isoform gamma-2 reviewed Kinase CSNK1G2 Thermal melting change '=' 2 degrees C
Q99683 BXGT019947 Mitogen-activated protein kinase kinase kinase 5 reviewed Kinase MAP3K5 Thermal melting change '=' 3 degrees C
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Inhibition '=' 65 %
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 15848 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 23109 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 19952 nM
Q96RR4 BXGT019734 Calcium/calmodulin-dependent protein kinase kinase 2 reviewed Kinase CAMKK2 Thermal melting change '=' 6 degrees C
Q00534 BXGT012533 Cyclin-dependent kinase 6 reviewed Kinase CDK6 Thermal melting change '=' 2 degrees C
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 reviewed Kinase CHEK2 Thermal melting change '=' 5 degrees C
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 Thermal melting change '=' 7 degrees C
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 reviewed Kinase PRKAA2 Thermal melting change '=' 0 degrees C
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Thermal melting change '=' 3 degrees C
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 52 %
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity - - -
Q39829 BXGT014381 Lipoxygenase unreviewed - Inhibition - - -
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Inhibition - - -
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 19952 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Inhibition - - -
P01100 BXGT005727 Proto-oncogene c-Fos reviewed Transcription factor FOS IC50 '=' 6 nM
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN IC50 '=' 6 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 89125 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 5011 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 5011 nM
P0AEK4 BXGT007320 Enoyl-[acyl-carrier-protein] reductase [NADH] FabI reviewed - fabI Ki '=' 14960 nM
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 1683 nM
P49761 BXGT010736 Dual specificity protein kinase CLK3 reviewed Kinase CLK3 Thermal melting change '=' 3 degrees C
Q16659 BXGT013652 Mitogen-activated protein kinase 6 reviewed Kinase MAPK6 Thermal melting change '=' 1 degrees C
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 reviewed Kinase PIM2 Thermal melting change '=' 2 degrees C
Q9H2G2 BXGT020452 STE20-like serine/threonine-protein kinase reviewed Kinase SLK Thermal melting change '=' 3 degrees C
Q8IV63 BXGT018341 Inactive serine/threonine-protein kinase VRK3 reviewed Kinase VRK3 Thermal melting change '=' 1 degrees C
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 Inhibition '=' 93 %
P03469 BXGT006080 Neuraminidase reviewed - NA IC50 '=' 10000 nM
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 IC50 '=' 33900 nM
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 reviewed Epigenetic regulator DNMT1 Inhibition '=' 66 %
P51955 BXGT010908 Serine/threonine-protein kinase Nek2 reviewed Kinase NEK2 Thermal melting change '=' 1 degrees C
Q9NQU5 BXGT021169 Serine/threonine-protein kinase PAK 6 reviewed - PAK6 Thermal melting change '=' 1 degrees C
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 reviewed Kinase PDPK1 Thermal melting change '=' 0 degrees C
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha reviewed Kinase PRKACA Thermal melting change '=' 3 degrees C
Q15208 BXGT013550 Serine/threonine-protein kinase 38 reviewed Kinase STK38 Thermal melting change '=' 2 degrees C
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 47 %
Q86Y07 BXGT017631 Serine/threonine-protein kinase VRK2 reviewed Kinase VRK2 Thermal melting change '=' 1 degrees C
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Kcat/Km '=' 3 /uM/s
B4URE7 BXGT002145 Hemagglutinin unreviewed - HA Activity '=' 16 -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Inhibition '=' 12 %
Q9BVS4 BXGT020147 Serine/threonine-protein kinase RIO2 reviewed Kinase RIOK2 Thermal melting change '=' 2 degrees C
P24822 BXGT008996 Intestinal-type alkaline phosphatase reviewed - Iap IC50 '=' 12000 nM
Q96NX5 BXGT019702 Calcium/calmodulin-dependent protein kinase type 1G reviewed Kinase CAMK1G Thermal melting change '=' 1 degrees C
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN Activity - - -
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA Inhibition - - -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Inhibition - - -
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 Inhibition - - -
Q9P286 BXGT021299 Serine/threonine-protein kinase PAK 5 reviewed Kinase PAK5 Thermal melting change '=' 1 degrees C
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Thermal melting change '=' 2 degrees C
Q9P289 BXGT021300 Serine/threonine-protein kinase 26 reviewed Kinase STK26 Thermal melting change '=' 2 degrees C
Q99986 BXGT019980 Serine/threonine-protein kinase VRK1 reviewed Kinase VRK1 Thermal melting change '=' 1 degrees C
Q13557 BXGT013376 Calcium/calmodulin-dependent protein kinase type II subunit delta reviewed Kinase CAMK2D Thermal melting change '=' 0 degrees C
P49760 BXGT010735 Dual specificity protein kinase CLK2 reviewed Kinase CLK2 Thermal melting change '=' 2 degrees C
Q9HCP0 BXGT020536 Casein kinase I isoform gamma-1 reviewed Kinase CSNK1G1 Thermal melting change '=' 4 degrees C
Q9Y6M4 BXGT022335 Casein kinase I isoform gamma-3 reviewed Kinase CSNK1G3 Thermal melting change '=' 0 degrees C
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 50 %
Q39829 BXGT014381 Lipoxygenase unreviewed - IC50 '=' 59520 nM
O96013 BXGT005414 Serine/threonine-protein kinase PAK 4 reviewed Kinase PAK4 Thermal melting change '=' 3 degrees C
Q9UKE5 BXGT021741 TRAF2 and NCK-interacting protein kinase reviewed Kinase TNIK Thermal melting change '=' 5 degrees C
Q96KB5 BXGT019685 Lymphokine-activated killer T-cell-originated protein kinase reviewed Kinase PBK Thermal melting change '=' 0 degrees C
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Activity - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Activity - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 70 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 20300 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 EC50 '=' 9900 nM
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES IC50 '=' 600 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 29650 nM
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 IC50 '=' 115000 nM
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 IC50 '=' 115000 nM
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 IC50 '=' 115000 nM
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 IC50 '=' 115000 nM
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 IC50 '=' 115000 nM
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 IC50 '=' 115000 nM
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 IC50 '=' 115000 nM
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 IC50 '=' 115000 nM
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 IC50 '=' 115000 nM
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 IC50 '=' 115000 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 '=' 115000 nM
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN IC50 '=' 12800 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Thermal melting change '=' 0 degrees C
Q9P289 BXGT021300 Serine/threonine-protein kinase 26 reviewed Kinase STK26 Thermal melting change '=' 1 degrees C
O95747 BXGT005393 Serine/threonine-protein kinase OSR1 reviewed Kinase OXSR1 Thermal melting change '=' 3 degrees C
O00444 BXGT003921 Serine/threonine-protein kinase PLK4 reviewed Kinase PLK4 Thermal melting change '=' 3 degrees C
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 50 %
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Thermal melting change '=' 2 degrees C
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 31622 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 31622 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 31622 nM
P01100 BXGT005727 Proto-oncogene c-Fos reviewed Transcription factor FOS IC50 '=' 480000 nM
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN IC50 '=' 480000 nM
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A IC50 '=' 37000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Inhibition - - -
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Thermal melting change '=' 1 degrees C
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 reviewed Kinase MAP2K2 Thermal melting change '=' 2 degrees C
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA MIC '=' 1 ug.mL-1
A0A0C5K5S3 BXGT000138 Fluoroquinolone resistance protein unreviewed - mdeA FC '=' 0 -
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA IC50 '=' 7 ug.mL-1
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 IC50 '=' 7 ug.mL-1
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 IC50 '=' 7 ug.mL-1
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 3900 nM
Q932Y6 BXGT019466 Beta-lactamase unreviewed - bla(tem-2) IC50 '=' 10769 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 62000 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 IC50 '=' 8200 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00068 Turmeric Curcuma longa Herbs and Spices
BXGF01954 Amomum tsao-ko Amomum tsao-ko Human Edible Plant
BXGF03733 Alpinia officinarum Alpinia officinarum Medicinal Plant
BXGF03970 Goniothalamus borneensis Goniothalamus borneensis Others
BXGF03980 Curcuma aromatica Curcuma aromatica Medicinal Plant
BXGF04173 Curcuma wenyujin Curcuma wenyujin Others
BXGF05024 Jacobaea maritima Jacobaea maritima Others
BXGF05071 Zingiber spectabile Zingiber spectabile Human Edible Plant
BXGF05816 Fraxinus quadrangulata Fraxinus quadrangulata Medicinal Plant
BXGF05934 Curcuma zedoaria Curcuma zedoaria Medicinal Plant
BXGF06181 Adiantum capillus-veneris Adiantum capillus-veneris Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease