Showing entry for curcumin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0024810
Compound Namecurcumin
Structure
FormulaC21H20O6
InchiKeyVFLDPWHFBUODDF-UHFFFAOYSA-N
SMILESCOc1cc(C=CC(=O)CC(=O)C=Cc2ccc(c(c2)OC)O)ccc1O
InchiInChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3
IUPAC1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Molecular Weight368.13
Pubchem Id2889
Chembl IdCHEMBL3187799
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 29532
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT013389 5-hydroxytryptamine receptor 4 reviewed G-protein coupled receptor HTR4 - - - 10000
reviewed BXGT006234 Gag-Pol polyprotein reviewed gag-pol - 10338.99975 - -
reviewed BXGT006524 Genome polyprotein reviewed - - >50000000 - -
reviewed BXGT010462 Collagenase 3 reviewed Enzyme MMP13 - 10350 - -
reviewed BXGT020189 Serine/threonine-protein kinase 33 reviewed Kinase STK33 - - - 710.2
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - 7410 - -
reviewed BXGT008148 Intestinal-type alkaline phosphatase 1 reviewed Alpi - 18700 - -
reviewed BXGT008148 Intestinal-type alkaline phosphatase 1 reviewed Alpi - 12000 - -
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - >100000 - -
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - 44100 - -
reviewed BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG - >100000 - -
reviewed BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG - 63500 - -
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - >100000 - -
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - >100000 - -
reviewed BXGT012099 Mitochondrial import inner membrane translocase subunit TIM10 reviewed TIM10 - 19700 - -
reviewed BXGT004860 Perilipin-1 reviewed PLIN1 - 9167 - -
reviewed BXGT012560 Perilipin-5 reviewed PLIN5 - 10232 - -
reviewed BXGT021181 Toll-like receptor 9 reviewed TLR9 - 8362 - -
reviewed BXGT021181 Toll-like receptor 9 reviewed TLR9 - 15266 - -
reviewed BXGT011541 Probable nicotinate-nucleotide adenylyltransferase reviewed nadD - 62700 - -
reviewed BXGT006136 Phospholipase A2 reviewed Enzyme PLA2G1B - 11100 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 31310 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 96360 - -
reviewed BXGT004082 Prostaglandin E synthase reviewed PTGES - 4880 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 3900 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 8100 - -
reviewed BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 - 33900 - -
reviewed BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 - - - 9900
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 500 - -
reviewed BXGT004082 Prostaglandin E synthase reviewed PTGES - 600 - -
reviewed BXGT004082 Prostaglandin E synthase reviewed PTGES - 1200 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 600 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - 1200 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 35090 - -
reviewed BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A - 13000 - -
reviewed BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A - 45000 - -
reviewed BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A - 34000 - -
reviewed BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A - 33000 - -
reviewed BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 - 5700 - -
reviewed BXGT006080 Neuraminidase reviewed NA - 10000 - -
reviewed BXGT006080 Neuraminidase reviewed NA - 8100 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 29650 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - >100000 - -
reviewed BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 - 5300 - -
reviewed BXGT013038 Histone acetyltransferase p300 reviewed EP300 - 6500 - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP - 3900 - -
reviewed BXGT013038 Histone acetyltransferase p300 reviewed EP300 - >400000 - -
reviewed BXGT007738 Cytochrome P450 2C9 reviewed CYP2C9 - 4300 - -
reviewed BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 - 16300 - -
reviewed BXGT008603 Cytochrome P450 2B6 reviewed CYP2B6 - 24500 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - 50300 - -
reviewed BXGT004737 Testosterone 17-beta-dehydrogenase 3 reviewed Hsd17b3 - 9000 - -
reviewed BXGT004737 Testosterone 17-beta-dehydrogenase 3 reviewed Hsd17b3 - 2300 - -
reviewed BXGT009956 Testosterone 17-beta-dehydrogenase 3 reviewed HSD17B3 - 67300 - -
reviewed BXGT008349 Cell division protein FtsZ reviewed ftsZ - 30000 - -
reviewed BXGT010352 Multidrug resistance protein CDR1 reviewed CDR1 - 14200 - -
reviewed BXGT010352 Multidrug resistance protein CDR1 reviewed CDR1 - 40000 - -
reviewed BXGT012782 Lactoylglutathione lyase reviewed GLO1 10000 - - -
reviewed BXGT005592 Pancreatic triacylglycerol lipase reviewed PNLIP - >250000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 79200 - -
reviewed BXGT012782 Lactoylglutathione lyase reviewed GLO1 10300 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - >100000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 11060 - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP 0.208 - - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 8000 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 52000 - -
reviewed BXGT009800 Nitric oxide synthase, inducible reviewed NOS2 - 6000 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 8800 - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP - 800 - -
reviewed BXGT010462 Collagenase 3 reviewed Enzyme MMP13 - 10300 - -
reviewed BXGT008161 CPG DNA methylase reviewed sssIM - 30 - -
reviewed BXGT019403 Histone acetyltransferase KAT5 reviewed KAT5 - >200000 - -
reviewed BXGT013038 Histone acetyltransferase p300 reviewed EP300 - >40000 - -
reviewed BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 - 8500 - -
reviewed BXGT007320 Enoyl-[acyl-carrier-protein] reductase [NADH] FabI reviewed fabI 14960 - - -
reviewed BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD - - - 10670
reviewed BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE - - - 8810
reviewed BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ - - - 11080
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 2410 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 380 - - -
reviewed BXGT006627 Carbonic anhydrase 3 reviewed CA3 11300 - - -
reviewed BXGT008802 Carbonic anhydrase 4 reviewed CA4 4970 - - -
reviewed BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed CA5A 10250 - - -
reviewed BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed CA5B 9460 - - -
reviewed BXGT008844 Carbonic anhydrase 6 reviewed CA6 9940 - - -
reviewed BXGT010364 Carbonic anhydrase 7 reviewed CA7 9300 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 4050 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 3480 - - -
reviewed BXGT018499 Carbonic anhydrase 13 reviewed CA13 6850 - - -
reviewed BXGT021769 Carbonic anhydrase 14 reviewed CA14 11730 - - -
reviewed BXGT019994 Carbonic anhydrase 15 reviewed Ca15 5090 - - -
reviewed BXGT021375 Toll-like receptor 4 reviewed Tlr4 - 6000 - -
reviewed BXGT007950 Tissue factor reviewed Receptor F3 - 200 - -
reviewed BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR - 8600 - -
reviewed BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR - - - 20000
reviewed BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 - 19250 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 81050 - -
reviewed BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed HSD11B1 - 15983 - -
reviewed BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed HSD11B1 - 4501 - -
reviewed BXGT008207 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed Hsd11b1 - 4125 - -
reviewed BXGT008207 Corticosteroid 11-beta-dehydrogenase isozyme 1 reviewed Hsd11b1 - 3921 - -
reviewed BXGT008087 Aminopeptidase N reviewed Enzyme ANPEP - 10000 - -
reviewed BXGT008088 Aminopeptidase N reviewed ANPEP - 15500 - -
CHEMBL CHEMBL3187799
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03970 Goniothalamus borneensis Goniothalamus borneensis Others
BXGF05024 Jacobaea maritima Jacobaea maritima Others
BXGF05816 Fraxinus quadrangulata Fraxinus quadrangulata Medicinal Plant
BXGF06181 Adiantum capillus-veneris Adiantum capillus-veneris Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease