Showing entry for Tyrosine-protein phosphatase non-receptor type 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022810
Protein NameTyrosine-protein phosphatase non-receptor type 3
Uniport IdP26045
GenePTPN3
Gene Id5774
DomainFERM_C; FERM_M; FERM_N; PDZ; Y_phosphatase
Pfam PF09380   PF00373   PF09379   PF00595   PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097421 liver regeneration
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0051045 negative regulation of membrane protein ectodomain proteolysis
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0098902 regulation of membrane depolarization during action potential
Biological Process GO:2000649 regulation of sodium ion transmembrane transporter activity
molecular function GO:0051117 ATPase binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0017080 sodium channel regulator activity
cellular component GO:0005737 cytoplasm
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005856 cytoskeleton
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-177929 Signaling by EGFR
R-HSA-182971 EGFR downregulation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001206 BXGD000033 Acromegaly Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0004779 BXGD000291 Basal Cell Nevus Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0005426 BXGD000314 Biliary Tract Neoplasm Digestive System Diseases; Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0232720 BXGD004559 Pale feces (finding) Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0268074 BXGD005810 Indian childhood cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Respiratory Tract Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0521158 BXGD009130 Recurrent tumor
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740277 BXGD009972 Bile duct carcinoma Digestive System Diseases; Neoplasms
C1135196 BXGD011694 Heart Failure, Diastolic Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675627 BXGD017302 Acholic stool Digestive System Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4045991 BXGD021888 Perihilar Cholangiocarcinoma Neoplasms
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein