Showing entry for Na(+)/H(+) exchange regulatory cofactor NHE-RF3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023979
Protein NameNa(+)/H(+) exchange regulatory cofactor NHE-RF3
Uniport IdQ5T2W1
GenePDZK1
Gene Id5174
DomainPDZ; PDZ_6
Pfam PF00595   PF17820  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015879 carnitine transport
Biological Process GO:1904064 positive regulation of cation transmembrane transport
Biological Process GO:0032414 positive regulation of ion transmembrane transporter activity
Biological Process GO:1905477 positive regulation of protein localization to membrane
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0044070 regulation of anion transport
Biological Process GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane
molecular function GO:0030165 PDZ domain binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0005124 scavenger receptor binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005903 brush border
cellular component GO:0031526 brush border membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0045121 membrane raft
cellular component GO:0031528 microvillus membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008372 BXGD000535 Intrahepatic Cholestasis Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009928 BXGD000637 Contrast Sensitivity
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0025218 BXGD001836 Chloasma Skin and Connective Tissue Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036095 BXGD002576 Salivary Gland Neoplasms Neoplasms; Stomatognathic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0202239 BXGD004087 Uric acid measurement (procedure)
C0220636 BXGD004304 Malignant neoplasm of salivary gland Neoplasms; Stomatognathic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0403823 BXGD008315 Asthenozoospermia Male Urogenital Diseases
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C4049446 BXGD021933 Neointimal hyperplasia
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein